Incidental Mutation 'IGL03283:Cyp4a32'
ID 415640
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Name cytochrome P450, family 4, subfamily a, polypeptide 32
Synonyms OTTMUSG00000008689
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # IGL03283
Quality Score
Status
Chromosome 4
Chromosomal Location 115458166-115478799 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 115468280 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 283 (K283N)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342]
AlphaFold A2A8T1
Predicted Effect possibly damaging
Transcript: ENSMUST00000084342
AA Change: K283N

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: K283N

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129918
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bicdl2 A G 17: 23,886,155 (GRCm39) E361G probably damaging Het
Cd163 A G 6: 124,286,158 (GRCm39) D236G possibly damaging Het
Cep76 A T 18: 67,773,139 (GRCm39) I53N possibly damaging Het
Cfap43 A G 19: 47,779,851 (GRCm39) probably benign Het
Champ1 T C 8: 13,928,786 (GRCm39) S315P probably benign Het
Ctdsp2 A G 10: 126,832,266 (GRCm39) T91A probably benign Het
Dgki A G 6: 36,914,246 (GRCm39) probably benign Het
Fads2b A C 2: 85,320,751 (GRCm39) F351V probably damaging Het
Gabrr2 A G 4: 33,082,364 (GRCm39) probably benign Het
Garin4 C T 1: 190,895,029 (GRCm39) R538H probably benign Het
Gm5414 G T 15: 101,535,522 (GRCm39) Q188K probably damaging Het
Grik2 A T 10: 49,454,365 (GRCm39) M50K probably benign Het
Muc5ac A G 7: 141,367,518 (GRCm39) M2980V probably benign Het
Pafah2 C T 4: 134,145,408 (GRCm39) T264M probably damaging Het
Tacc2 A G 7: 130,343,996 (GRCm39) M2552V possibly damaging Het
Usp3 C T 9: 66,469,831 (GRCm39) probably null Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115,467,700 (GRCm39) missense probably benign
IGL02546:Cyp4a32 APN 4 115,468,520 (GRCm39) missense probably damaging 0.98
IGL02578:Cyp4a32 APN 4 115,466,939 (GRCm39) missense possibly damaging 0.79
IGL02663:Cyp4a32 APN 4 115,467,787 (GRCm39) missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115,471,818 (GRCm39) missense probably damaging 0.99
IGL03357:Cyp4a32 APN 4 115,468,798 (GRCm39) missense probably benign 0.00
IGL03406:Cyp4a32 APN 4 115,459,500 (GRCm39) missense probably benign 0.00
R0379:Cyp4a32 UTSW 4 115,478,671 (GRCm39) missense probably damaging 1.00
R1339:Cyp4a32 UTSW 4 115,468,760 (GRCm39) missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115,463,863 (GRCm39) missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115,460,147 (GRCm39) nonsense probably null
R1520:Cyp4a32 UTSW 4 115,471,849 (GRCm39) missense probably damaging 0.97
R1587:Cyp4a32 UTSW 4 115,467,731 (GRCm39) missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115,468,505 (GRCm39) missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115,468,474 (GRCm39) missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115,478,720 (GRCm39) missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115,460,126 (GRCm39) splice site silent
R5004:Cyp4a32 UTSW 4 115,458,238 (GRCm39) missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115,459,560 (GRCm39) missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115,466,894 (GRCm39) missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115,459,499 (GRCm39) missense probably benign
R7419:Cyp4a32 UTSW 4 115,468,234 (GRCm39) missense probably benign
R7716:Cyp4a32 UTSW 4 115,458,283 (GRCm39) missense probably damaging 1.00
R8921:Cyp4a32 UTSW 4 115,468,460 (GRCm39) missense probably damaging 0.99
R9009:Cyp4a32 UTSW 4 115,467,802 (GRCm39) missense probably null 1.00
R9266:Cyp4a32 UTSW 4 115,468,307 (GRCm39) missense probably damaging 1.00
R9330:Cyp4a32 UTSW 4 115,478,635 (GRCm39) missense probably damaging 1.00
R9345:Cyp4a32 UTSW 4 115,467,699 (GRCm39) missense probably benign
R9442:Cyp4a32 UTSW 4 115,468,422 (GRCm39) missense probably benign 0.21
Z1177:Cyp4a32 UTSW 4 115,468,542 (GRCm39) missense probably benign 0.03
Posted On 2016-08-02