Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03284:Vmn2r107'

415654

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL03284

Quality Score

Status

Chromosome

Chromosomal Location

20565687-20596034 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20577173 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 390 (D390E)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably benign
Transcript: ENSMUST00000042090
AA Change: D390E

PolyPhen 2 Score 0.066 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: D390E

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam5	A	T	8: 25,276,354 (GRCm39)		probably benign	Het
Atxn7l3b	T	C	10: 112,764,431 (GRCm39)	D66G	probably benign	Het
Dmac2	T	C	7: 25,321,851 (GRCm39)		probably null	Het
Ephb2	A	G	4: 136,388,827 (GRCm39)	M590T	probably damaging	Het
Fbxo41	C	T	6: 85,456,747 (GRCm39)	R474H	probably damaging	Het
Fcgbp	G	T	7: 27,784,857 (GRCm39)	A306S	possibly damaging	Het
Hapstr1	A	G	16: 8,673,786 (GRCm39)	I238V	possibly damaging	Het
Hmg20a	A	G	9: 56,388,901 (GRCm39)	D156G	probably benign	Het
Mast4	A	G	13: 102,887,905 (GRCm39)	V1168A	probably damaging	Het
Oog2	A	G	4: 143,923,177 (GRCm39)		probably benign	Het
Pate12	T	A	9: 36,344,759 (GRCm39)	C96S	probably damaging	Het
Pkhd1l1	T	A	15: 44,410,914 (GRCm39)		probably benign	Het
Psmd6	A	T	14: 14,112,546 (GRCm38)	N351K	probably benign	Het
Ralgps1	T	C	2: 33,036,577 (GRCm39)		probably benign	Het
Rbl1	C	T	2: 157,035,989 (GRCm39)		probably benign	Het
Smarcc1	G	A	9: 110,004,142 (GRCm39)	V399I	probably benign	Het
Srek1	C	A	13: 103,897,045 (GRCm39)	V99F	probably damaging	Het
Styxl1	A	G	5: 135,785,949 (GRCm39)	V32A	possibly damaging	Het
Tnn	C	T	1: 159,953,022 (GRCm39)	V673I	probably benign	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20,596,009 (GRCm39)	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20,565,868 (GRCm39)	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20,578,062 (GRCm39)	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20,595,168 (GRCm39)	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20,577,039 (GRCm39)	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20,595,823 (GRCm39)	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20,577,006 (GRCm39)	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20,578,017 (GRCm39)	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20,595,974 (GRCm39)	missense	probably benign	0.05
IGL03307:Vmn2r107	APN	17	20,577,038 (GRCm39)	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20,578,220 (GRCm39)	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20,565,766 (GRCm39)	missense	probably benign
BB006:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20,565,873 (GRCm39)	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20,595,085 (GRCm39)	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20,595,394 (GRCm39)	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20,578,021 (GRCm39)	missense	probably benign
R0621:Vmn2r107	UTSW	17	20,595,252 (GRCm39)	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20,575,916 (GRCm39)	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20,576,860 (GRCm39)	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20,578,031 (GRCm39)	missense	probably benign
R1237:Vmn2r107	UTSW	17	20,576,947 (GRCm39)	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20,595,109 (GRCm39)	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20,576,775 (GRCm39)	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20,565,840 (GRCm39)	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20,575,879 (GRCm39)	splice site	probably null
R2009:Vmn2r107	UTSW	17	20,595,729 (GRCm39)	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20,595,549 (GRCm39)	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20,595,904 (GRCm39)	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20,595,817 (GRCm39)	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20,580,607 (GRCm39)	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20,595,151 (GRCm39)	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20,595,717 (GRCm39)	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20,595,483 (GRCm39)	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20,576,041 (GRCm39)	missense	probably benign
R4963:Vmn2r107	UTSW	17	20,595,403 (GRCm39)	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20,576,015 (GRCm39)	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20,595,426 (GRCm39)	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20,595,316 (GRCm39)	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20,565,849 (GRCm39)	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20,576,044 (GRCm39)	missense	probably benign	0.00
R6467:Vmn2r107	UTSW	17	20,595,939 (GRCm39)	missense	probably damaging	0.99
R6726:Vmn2r107	UTSW	17	20,595,637 (GRCm39)	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20,577,141 (GRCm39)	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20,565,878 (GRCm39)	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20,576,138 (GRCm39)	missense	probably benign
R7448:Vmn2r107	UTSW	17	20,595,994 (GRCm39)	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20,595,271 (GRCm39)	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20,595,634 (GRCm39)	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20,580,635 (GRCm39)	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20,576,901 (GRCm39)	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20,565,706 (GRCm39)	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20,577,270 (GRCm39)	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20,595,808 (GRCm39)	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20,580,614 (GRCm39)	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20,577,239 (GRCm39)	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20,577,051 (GRCm39)	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20,595,149 (GRCm39)	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20,580,661 (GRCm39)	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20,577,262 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20,577,230 (GRCm39)	missense	possibly damaging	0.85

Posted On

2016-08-02