Incidental Mutation 'IGL03287:Zmynd12'
ID415770
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zmynd12
Ensembl Gene ENSMUSG00000070806
Gene Namezinc finger, MYND domain containing 12
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL03287
Quality Score
Status
Chromosome4
Chromosomal Location119422814-119467444 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 119453579 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 328 (E328G)
Ref Sequence ENSEMBL: ENSMUSP00000092414 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094819]
Predicted Effect probably damaging
Transcript: ENSMUST00000094819
AA Change: E328G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092414
Gene: ENSMUSG00000070806
AA Change: E328G

DomainStartEndE-ValueType
Pfam:zf-MYND 17 54 1.2e-10 PFAM
low complexity region 70 87 N/A INTRINSIC
Blast:TPR 88 121 2e-14 BLAST
Pfam:TPR_8 130 157 3.9e-3 PFAM
Pfam:TPR_8 172 196 1.5e-2 PFAM
Blast:TPR 214 247 2e-13 BLAST
low complexity region 305 319 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129150
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134147
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519G04Rik A T 5: 114,870,176 D17V probably damaging Het
Cdh5 T A 8: 104,128,115 V225E probably damaging Het
Cfap52 C T 11: 67,935,976 probably benign Het
Cib4 A G 5: 30,488,543 L127P probably benign Het
Fbln2 A G 6: 91,233,494 H140R probably damaging Het
Grm8 A G 6: 27,760,255 F359L possibly damaging Het
Kat7 A T 11: 95,300,109 D150E probably damaging Het
Kif1b A G 4: 149,214,981 I944T possibly damaging Het
Krt87 T C 15: 101,432,337 probably benign Het
Mast1 T C 8: 84,913,353 S1142G probably benign Het
Neb A G 2: 52,137,323 Y6889H probably damaging Het
Olfr1 A T 11: 73,396,019 M1K probably null Het
Olfr1337 A G 4: 118,782,354 V77A possibly damaging Het
Plk4 A T 3: 40,805,118 I150L probably benign Het
Scn5a T C 9: 119,489,778 D1598G probably damaging Het
Skor2 A G 18: 76,876,135 K925E probably damaging Het
Slc25a29 A T 12: 108,831,209 F22L possibly damaging Het
Slc27a2 A G 2: 126,553,392 T80A probably damaging Het
Tlr3 A G 8: 45,402,780 V121A probably benign Het
Tubgcp3 A T 8: 12,639,630 D545E possibly damaging Het
Zdhhc8 T C 16: 18,225,100 Y412C probably benign Het
Other mutations in Zmynd12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01603:Zmynd12 APN 4 119441920 critical splice donor site probably null
IGL02113:Zmynd12 APN 4 119433997 missense probably damaging 1.00
IGL02701:Zmynd12 APN 4 119444755 splice site probably benign
IGL03138:Zmynd12 UTSW 4 119422989 missense probably damaging 1.00
R4531:Zmynd12 UTSW 4 119422997 critical splice donor site probably null
R5078:Zmynd12 UTSW 4 119444850 missense probably damaging 1.00
R5687:Zmynd12 UTSW 4 119441901 missense probably damaging 0.96
R6995:Zmynd12 UTSW 4 119453575 missense probably benign 0.00
R7707:Zmynd12 UTSW 4 119444866 missense probably damaging 1.00
R8393:Zmynd12 UTSW 4 119448155 missense probably damaging 1.00
X0019:Zmynd12 UTSW 4 119450368 missense probably benign 0.04
Z1176:Zmynd12 UTSW 4 119422877 unclassified probably benign
Posted On2016-08-02