Incidental Mutation 'IGL03290:Il22'
ID 415891
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il22
Ensembl Gene ENSMUSG00000074695
Gene Name interleukin 22
Synonyms IL-TIF, Iltif, IL-22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.110) question?
Stock # IGL03290
Quality Score
Status
Chromosome 10
Chromosomal Location 118204942-118210047 bp(+) (GRCm38)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 118205880 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000094449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096691]
AlphaFold Q9JJY9
Predicted Effect probably null
Transcript: ENSMUST00000096691
SMART Domains Protein: ENSMUSP00000094449
Gene: ENSMUSG00000074695

DomainStartEndE-ValueType
IL10 49 179 7.88e-1 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutation of this locus results in abnormalities in Il23-induced dermal inflammation and acanthosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 A G 7: 119,703,423 probably benign Het
Asb18 A G 1: 90,014,574 S2P probably damaging Het
Atp2b2 A G 6: 113,793,754 F398S probably damaging Het
BC034090 T G 1: 155,226,110 D136A probably damaging Het
Ces5a A C 8: 93,519,632 F310V probably damaging Het
Chsy1 T C 7: 66,171,031 V338A probably benign Het
Dbh A G 2: 27,174,932 E385G probably damaging Het
Dnah14 T A 1: 181,763,978 probably benign Het
F2rl1 A G 13: 95,513,589 S262P possibly damaging Het
Fat2 T C 11: 55,256,219 N3984D probably benign Het
Fbxo38 A T 18: 62,526,163 H354Q probably benign Het
Fgf6 T A 6: 127,024,132 V201D probably damaging Het
Gm16181 A T 17: 35,223,957 probably benign Het
Gm6811 T C 17: 21,094,049 noncoding transcript Het
Gna11 A G 10: 81,530,937 F313S probably damaging Het
Gprc6a C T 10: 51,615,872 A523T probably damaging Het
Insr T C 8: 3,258,574 Y154C probably damaging Het
Irak4 T A 15: 94,551,899 D86E probably benign Het
Itk C A 11: 46,334,937 W529L probably damaging Het
Klhl6 C A 16: 19,947,137 A572S probably benign Het
Ldhc C T 7: 46,869,688 R112C probably damaging Het
Lrrc56 T C 7: 141,199,772 probably benign Het
Mdh2 A G 5: 135,789,713 E274G probably damaging Het
N4bp1 G T 8: 86,848,533 D711E probably benign Het
Ngly1 T A 14: 16,281,866 I248K probably damaging Het
Olfr324 A G 11: 58,598,323 N309S probably damaging Het
Olfr872 T C 9: 20,260,260 I140T probably damaging Het
Pbrm1 A G 14: 31,107,284 E1421G probably damaging Het
Pcca G A 14: 122,585,106 R112H possibly damaging Het
Pgrmc2 T C 3: 41,068,626 probably benign Het
Podnl1 G A 8: 84,132,189 V548I probably benign Het
Pogz A T 3: 94,875,091 probably benign Het
Ppp1r3a A G 6: 14,754,772 Y159H probably damaging Het
Rax T C 18: 65,938,160 K135E probably damaging Het
Rbm7 T A 9: 48,489,967 M154L probably benign Het
Rp1 A G 1: 4,350,041 S283P probably damaging Het
Rpusd4 T C 9: 35,267,977 S30P probably benign Het
Samd13 T C 3: 146,646,315 T75A probably benign Het
Sfxn4 A G 19: 60,860,070 W22R probably damaging Het
Sh3pxd2a T A 19: 47,424,516 R43W probably damaging Het
Smc5 A G 19: 23,273,658 V54A probably benign Het
Snap47 A G 11: 59,428,598 I238T probably damaging Het
Tecpr2 T G 12: 110,967,833 I1309S possibly damaging Het
Trappc8 A G 18: 20,820,935 L1310P probably damaging Het
Vmn2r61 T A 7: 42,265,984 H118Q probably benign Het
Zbtb17 C T 4: 141,466,933 T731I probably damaging Het
Zfp287 A G 11: 62,715,236 F282L probably damaging Het
Other mutations in Il22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03204:Il22 APN 10 118205180 splice site probably benign
PIT4651001:Il22 UTSW 10 118205590 missense probably damaging 1.00
R0184:Il22 UTSW 10 118205606 missense probably damaging 1.00
R3905:Il22 UTSW 10 118205624 nonsense probably null
R3908:Il22 UTSW 10 118205624 nonsense probably null
R4703:Il22 UTSW 10 118205606 missense probably damaging 1.00
R4797:Il22 UTSW 10 118205153 missense probably damaging 0.98
R4799:Il22 UTSW 10 118205153 missense probably damaging 0.98
R5439:Il22 UTSW 10 118209461 nonsense probably null
R5496:Il22 UTSW 10 118205097 missense possibly damaging 0.73
R5957:Il22 UTSW 10 118205166 missense probably damaging 1.00
R6584:Il22 UTSW 10 118205027 missense probably benign 0.00
R6862:Il22 UTSW 10 118205810 missense probably benign 0.41
R7381:Il22 UTSW 10 118205164 missense possibly damaging 0.48
R8095:Il22 UTSW 10 118205123 missense possibly damaging 0.95
Posted On 2016-08-02