Incidental Mutation 'IGL03291:Olfml1'
ID415904
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfml1
Ensembl Gene ENSMUSG00000051041
Gene Nameolfactomedin-like 1
SynonymsONT2, mONT2, MVAL564
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.068) question?
Stock #IGL03291
Quality Score
Status
Chromosome7
Chromosomal Location107567446-107591094 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 107590229 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 167 (D167G)
Ref Sequence ENSEMBL: ENSMUSP00000114029 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120990]
Predicted Effect probably damaging
Transcript: ENSMUST00000120990
AA Change: D167G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: D167G

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
coiled coil region 78 105 N/A INTRINSIC
low complexity region 115 132 N/A INTRINSIC
Pfam:OLF 145 233 5.5e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207374
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207852
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano1 T A 7: 144,621,675 E502V probably damaging Het
Atic T C 1: 71,570,922 V364A probably benign Het
Cfap44 A T 16: 44,407,311 H125L possibly damaging Het
Ctnna2 T A 6: 76,973,712 E227V probably damaging Het
Ctsf A G 19: 4,859,634 I378V probably benign Het
Eya1 C T 1: 14,184,348 probably null Het
Fat2 C T 11: 55,262,595 R3597H probably benign Het
Gdpd5 T C 7: 99,460,121 probably benign Het
Glcci1 T A 6: 8,579,678 I293K probably damaging Het
Gm16503 T A 4: 147,541,078 Y10N unknown Het
Gm5930 A T 14: 44,331,448 I239N possibly damaging Het
Grm5 T C 7: 88,130,796 L1148P probably damaging Het
Kmt2e T A 5: 23,499,291 L1161I probably damaging Het
Megf9 C T 4: 70,488,150 V260I probably benign Het
Mme T A 3: 63,346,104 D456E probably benign Het
Mup8 T A 4: 60,221,950 E61V probably damaging Het
Olfr615 T A 7: 103,560,912 M145K possibly damaging Het
Piezo2 T C 18: 63,021,308 K2467E probably damaging Het
Plscr1 T A 9: 92,266,870 F254L probably damaging Het
Prol1 A T 5: 88,328,520 K256N unknown Het
Rapgef4 A T 2: 72,195,703 L339F probably damaging Het
Slc27a2 T C 2: 126,564,750 I118T probably benign Het
Smim7 A T 8: 72,569,994 F19L possibly damaging Het
Svil T A 18: 5,056,150 L428* probably null Het
Tcof1 T C 18: 60,829,061 T699A possibly damaging Het
Thsd7b T A 1: 129,760,355 S668T possibly damaging Het
Tmprss7 T C 16: 45,680,748 D230G probably benign Het
Tyw1 A G 5: 130,299,993 D540G probably damaging Het
Zfp763 A G 17: 33,019,886 V95A probably damaging Het
Other mutations in Olfml1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Olfml1 APN 7 107590157 missense possibly damaging 0.80
IGL02355:Olfml1 APN 7 107567803 missense probably benign 0.00
IGL02362:Olfml1 APN 7 107567803 missense probably benign 0.00
IGL03218:Olfml1 APN 7 107571269 missense possibly damaging 0.87
R0041:Olfml1 UTSW 7 107590186 missense possibly damaging 0.81
R0041:Olfml1 UTSW 7 107590186 missense possibly damaging 0.81
R0081:Olfml1 UTSW 7 107571299 missense probably benign 0.08
R0524:Olfml1 UTSW 7 107590177 missense probably damaging 1.00
R1311:Olfml1 UTSW 7 107567896 critical splice donor site probably null
R1548:Olfml1 UTSW 7 107590375 missense possibly damaging 0.88
R1564:Olfml1 UTSW 7 107571139 missense possibly damaging 0.89
R4347:Olfml1 UTSW 7 107567833 missense probably benign 0.00
R4997:Olfml1 UTSW 7 107571206 missense probably damaging 1.00
R6788:Olfml1 UTSW 7 107567868 missense probably damaging 1.00
R7282:Olfml1 UTSW 7 107590323 missense possibly damaging 0.85
R7703:Olfml1 UTSW 7 107571185 missense probably damaging 1.00
R7922:Olfml1 UTSW 7 107571149 missense probably damaging 1.00
R8324:Olfml1 UTSW 7 107590363 missense probably benign 0.04
Posted On2016-08-02