Incidental Mutation 'IGL03291:Olfml1'
| ID |
415904 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Olfml1
|
| Ensembl Gene |
ENSMUSG00000051041 |
| Gene Name |
olfactomedin-like 1 |
| Synonyms |
mONT2, ONT2, MVAL564 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.081)
|
| Stock # |
IGL03291
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
107166653-107190301 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 107189436 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 167
(D167G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114029
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000120990]
|
| AlphaFold |
Q8BSH2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120990
AA Change: D167G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000114029
Gene: ENSMUSG00000051041
AA Change: D167G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
coiled coil region
|
78 |
105 |
N/A |
INTRINSIC |
|
low complexity region
|
115 |
132 |
N/A |
INTRINSIC |
|
Pfam:OLF
|
145 |
233 |
5.5e-19 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207374
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000207852
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano1 |
T |
A |
7: 144,175,412 (GRCm39) |
E502V |
probably damaging |
Het |
| Atic |
T |
C |
1: 71,610,081 (GRCm39) |
V364A |
probably benign |
Het |
| Cfap44 |
A |
T |
16: 44,227,674 (GRCm39) |
H125L |
possibly damaging |
Het |
| Ctnna2 |
T |
A |
6: 76,950,695 (GRCm39) |
E227V |
probably damaging |
Het |
| Ctsf |
A |
G |
19: 4,909,662 (GRCm39) |
I378V |
probably benign |
Het |
| Eya1 |
C |
T |
1: 14,254,572 (GRCm39) |
|
probably null |
Het |
| Fat2 |
C |
T |
11: 55,153,421 (GRCm39) |
R3597H |
probably benign |
Het |
| Gdpd5 |
T |
C |
7: 99,109,328 (GRCm39) |
|
probably benign |
Het |
| Glcci1 |
T |
A |
6: 8,579,678 (GRCm39) |
I293K |
probably damaging |
Het |
| Gm16503 |
T |
A |
4: 147,625,535 (GRCm39) |
Y10N |
unknown |
Het |
| Gm5930 |
A |
T |
14: 44,568,905 (GRCm39) |
I239N |
possibly damaging |
Het |
| Grm5 |
T |
C |
7: 87,780,004 (GRCm39) |
L1148P |
probably damaging |
Het |
| Kmt2e |
T |
A |
5: 23,704,289 (GRCm39) |
L1161I |
probably damaging |
Het |
| Megf9 |
C |
T |
4: 70,406,387 (GRCm39) |
V260I |
probably benign |
Het |
| Mme |
T |
A |
3: 63,253,525 (GRCm39) |
D456E |
probably benign |
Het |
| Mup8 |
T |
A |
4: 60,221,950 (GRCm39) |
E61V |
probably damaging |
Het |
| Or51ah3 |
T |
A |
7: 103,210,119 (GRCm39) |
M145K |
possibly damaging |
Het |
| Piezo2 |
T |
C |
18: 63,154,379 (GRCm39) |
K2467E |
probably damaging |
Het |
| Plscr1 |
T |
A |
9: 92,148,923 (GRCm39) |
F254L |
probably damaging |
Het |
| Prol1 |
A |
T |
5: 88,476,379 (GRCm39) |
K256N |
unknown |
Het |
| Rapgef4 |
A |
T |
2: 72,026,047 (GRCm39) |
L339F |
probably damaging |
Het |
| Slc27a2 |
T |
C |
2: 126,406,670 (GRCm39) |
I118T |
probably benign |
Het |
| Smim7 |
A |
T |
8: 73,323,838 (GRCm39) |
F19L |
possibly damaging |
Het |
| Svil |
T |
A |
18: 5,056,150 (GRCm39) |
L428* |
probably null |
Het |
| Tcof1 |
T |
C |
18: 60,962,133 (GRCm39) |
T699A |
possibly damaging |
Het |
| Thsd7b |
T |
A |
1: 129,688,092 (GRCm39) |
S668T |
possibly damaging |
Het |
| Tmprss7 |
T |
C |
16: 45,501,111 (GRCm39) |
D230G |
probably benign |
Het |
| Tyw1 |
A |
G |
5: 130,328,834 (GRCm39) |
D540G |
probably damaging |
Het |
| Zfp763 |
A |
G |
17: 33,238,860 (GRCm39) |
V95A |
probably damaging |
Het |
|
| Other mutations in Olfml1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01285:Olfml1
|
APN |
7 |
107,189,364 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02355:Olfml1
|
APN |
7 |
107,167,010 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02362:Olfml1
|
APN |
7 |
107,167,010 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03218:Olfml1
|
APN |
7 |
107,170,476 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0041:Olfml1
|
UTSW |
7 |
107,189,393 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0041:Olfml1
|
UTSW |
7 |
107,189,393 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R0081:Olfml1
|
UTSW |
7 |
107,170,506 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0524:Olfml1
|
UTSW |
7 |
107,189,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1311:Olfml1
|
UTSW |
7 |
107,167,103 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Olfml1
|
UTSW |
7 |
107,189,582 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1564:Olfml1
|
UTSW |
7 |
107,170,346 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4347:Olfml1
|
UTSW |
7 |
107,167,040 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4997:Olfml1
|
UTSW |
7 |
107,170,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6788:Olfml1
|
UTSW |
7 |
107,167,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7282:Olfml1
|
UTSW |
7 |
107,189,530 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7703:Olfml1
|
UTSW |
7 |
107,170,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7922:Olfml1
|
UTSW |
7 |
107,170,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8324:Olfml1
|
UTSW |
7 |
107,189,570 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8441:Olfml1
|
UTSW |
7 |
107,166,977 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9002:Olfml1
|
UTSW |
7 |
107,189,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9261:Olfml1
|
UTSW |
7 |
107,167,007 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9797:Olfml1
|
UTSW |
7 |
107,167,069 (GRCm39) |
missense |
probably benign |
0.25 |
|
| Posted On |
2016-08-02 |
Incidental Mutation