Incidental Mutation 'IGL03295:Zscan21'
ID416040
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zscan21
Ensembl Gene ENSMUSG00000037017
Gene Namezinc finger and SCAN domain containing 21
SynonymsRU49, Zipro1, Zfp38, CTfin51, Zfp-38
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03295
Quality Score
Status
Chromosome5
Chromosomal Location138116903-138134265 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 138125278 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 73 (D73G)
Ref Sequence ENSEMBL: ENSMUSP00000119570 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062350] [ENSMUST00000080732] [ENSMUST00000110959] [ENSMUST00000110960] [ENSMUST00000110961] [ENSMUST00000136425]
Predicted Effect unknown
Transcript: ENSMUST00000062350
AA Change: D73G
SMART Domains Protein: ENSMUSP00000053430
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect unknown
Transcript: ENSMUST00000080732
AA Change: D73G
SMART Domains Protein: ENSMUSP00000079557
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect unknown
Transcript: ENSMUST00000110959
AA Change: D73G
SMART Domains Protein: ENSMUSP00000106584
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect unknown
Transcript: ENSMUST00000110960
AA Change: D73G
SMART Domains Protein: ENSMUSP00000106585
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect unknown
Transcript: ENSMUST00000110961
AA Change: D73G
SMART Domains Protein: ENSMUSP00000106586
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
low complexity region 28 37 N/A INTRINSIC
SCAN 118 230 1.7e-80 SMART
ZnF_C2H2 359 381 3.95e-4 SMART
ZnF_C2H2 387 409 4.87e-4 SMART
ZnF_C2H2 415 436 1.26e1 SMART
ZnF_C2H2 442 464 4.3e-5 SMART
ZnF_C2H2 470 492 3.95e-4 SMART
ZnF_C2H2 498 520 1.38e-3 SMART
ZnF_C2H2 526 548 2.2e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000136425
AA Change: D73G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000119570
Gene: ENSMUSG00000037017
AA Change: D73G

DomainStartEndE-ValueType
internal_repeat_1 18 58 3.16e-6 PROSPERO
Pfam:SCAN 116 160 2.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142185
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation appear to be phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A T 5: 99,243,056 probably benign Het
Adamts5 T C 16: 85,877,945 T444A probably damaging Het
Aldh18a1 T C 19: 40,562,942 E522G probably damaging Het
Bbx T C 16: 50,224,564 T437A probably damaging Het
Bsx A G 9: 40,874,447 probably benign Het
C330027C09Rik T C 16: 48,994,341 S22P probably damaging Het
Cdc42bpa A G 1: 180,150,204 N729S probably benign Het
Cdk1 G T 10: 69,342,543 H162Q possibly damaging Het
Chrac1 A G 15: 73,093,596 probably benign Het
Ddx60 A T 8: 61,956,121 D397V possibly damaging Het
Edn2 T A 4: 120,161,981 C56S probably damaging Het
Gm13103 G A 4: 143,853,189 C448Y probably damaging Het
Gm4952 T C 19: 12,618,327 V27A probably benign Het
Herc1 T A 9: 66,396,703 S763T possibly damaging Het
Hspd1 G A 1: 55,080,175 T381I probably benign Het
Krt2 T A 15: 101,816,429 I249F probably damaging Het
Lman2l T C 1: 36,438,811 D148G probably damaging Het
Lrp1b C T 2: 40,678,987 probably null Het
Mier3 C A 13: 111,703,681 T51K probably benign Het
Ppp1r36 C T 12: 76,438,418 P305L probably damaging Het
Prdm1 T C 10: 44,439,870 I790V probably damaging Het
Sephs2 T C 7: 127,272,769 E384G possibly damaging Het
Sipa1l1 T A 12: 82,432,940 W1466R probably damaging Het
Snai2 T C 16: 14,706,774 L48P possibly damaging Het
Stt3a A G 9: 36,763,331 probably null Het
Synj1 T A 16: 90,938,430 N1545I probably benign Het
Vav2 A T 2: 27,275,029 S607T possibly damaging Het
Wdr27 T C 17: 14,934,575 K27E possibly damaging Het
Xcl1 A T 1: 164,935,435 V19E unknown Het
Xlr3c A T X: 73,257,634 probably null Het
Zbtb44 T A 9: 31,053,457 D54E probably benign Het
Other mutations in Zscan21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00775:Zscan21 APN 5 138133048 nonsense probably null
IGL02348:Zscan21 APN 5 138133383 missense probably damaging 0.99
R0454:Zscan21 UTSW 5 138133603 missense possibly damaging 0.77
R0471:Zscan21 UTSW 5 138125140 missense probably benign 0.33
R1465:Zscan21 UTSW 5 138125208 missense probably benign 0.18
R1465:Zscan21 UTSW 5 138125208 missense probably benign 0.18
R1860:Zscan21 UTSW 5 138126630 missense probably benign 0.00
R5498:Zscan21 UTSW 5 138133260 missense probably benign
R5851:Zscan21 UTSW 5 138126478 missense probably benign 0.39
R6213:Zscan21 UTSW 5 138125097 missense probably benign 0.09
R7079:Zscan21 UTSW 5 138126466 missense probably benign 0.11
R7448:Zscan21 UTSW 5 138117848 start gained probably benign
Posted On2016-08-02