Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03295:Zscan21'

416040

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan21

Ensembl Gene

ENSMUSG00000037017

Gene Name

zinc finger and SCAN domain containing 21

Synonyms

RU49, Zipro1, Zfp38, CTfin51, Zfp-38

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03295

Quality Score

Status

Chromosome

Chromosomal Location

138116903-138134265 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 138125278 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 73 (D73G)

Ref Sequence

ENSEMBL: ENSMUSP00000119570 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062350] [ENSMUST00000080732] [ENSMUST00000110959] [ENSMUST00000110960] [ENSMUST00000110961] [ENSMUST00000136425]

Predicted Effect

unknown
Transcript: ENSMUST00000062350
AA Change: D73G

SMART Domains

Protein: ENSMUSP00000053430
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000080732
AA Change: D73G

SMART Domains

Protein: ENSMUSP00000079557
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000110959
AA Change: D73G

SMART Domains

Protein: ENSMUSP00000106584
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000110960
AA Change: D73G

SMART Domains

Protein: ENSMUSP00000106585
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000110961
AA Change: D73G

SMART Domains

Protein: ENSMUSP00000106586
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
low complexity region	28	37	N/A	INTRINSIC
SCAN	118	230	1.7e-80	SMART
ZnF_C2H2	359	381	3.95e-4	SMART
ZnF_C2H2	387	409	4.87e-4	SMART
ZnF_C2H2	415	436	1.26e1	SMART
ZnF_C2H2	442	464	4.3e-5	SMART
ZnF_C2H2	470	492	3.95e-4	SMART
ZnF_C2H2	498	520	1.38e-3	SMART
ZnF_C2H2	526	548	2.2e-2	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000136425
AA Change: D73G

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000119570
Gene: ENSMUSG00000037017
AA Change: D73G

Domain	Start	End	E-Value	Type
internal_repeat_1	18	58	3.16e-6	PROSPERO
Pfam:SCAN	116	160	2.5e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000142185

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygotes for a targeted null mutation appear to be phenotypically normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	A	T	5: 99,243,056		probably benign	Het
Adamts5	T	C	16: 85,877,945	T444A	probably damaging	Het
Aldh18a1	T	C	19: 40,562,942	E522G	probably damaging	Het
Bbx	T	C	16: 50,224,564	T437A	probably damaging	Het
Bsx	A	G	9: 40,874,447		probably benign	Het
C330027C09Rik	T	C	16: 48,994,341	S22P	probably damaging	Het
Cdc42bpa	A	G	1: 180,150,204	N729S	probably benign	Het
Cdk1	G	T	10: 69,342,543	H162Q	possibly damaging	Het
Chrac1	A	G	15: 73,093,596		probably benign	Het
Ddx60	A	T	8: 61,956,121	D397V	possibly damaging	Het
Edn2	T	A	4: 120,161,981	C56S	probably damaging	Het
Gm13103	G	A	4: 143,853,189	C448Y	probably damaging	Het
Gm4952	T	C	19: 12,618,327	V27A	probably benign	Het
Herc1	T	A	9: 66,396,703	S763T	possibly damaging	Het
Hspd1	G	A	1: 55,080,175	T381I	probably benign	Het
Krt2	T	A	15: 101,816,429	I249F	probably damaging	Het
Lman2l	T	C	1: 36,438,811	D148G	probably damaging	Het
Lrp1b	C	T	2: 40,678,987		probably null	Het
Mier3	C	A	13: 111,703,681	T51K	probably benign	Het
Ppp1r36	C	T	12: 76,438,418	P305L	probably damaging	Het
Prdm1	T	C	10: 44,439,870	I790V	probably damaging	Het
Sephs2	T	C	7: 127,272,769	E384G	possibly damaging	Het
Sipa1l1	T	A	12: 82,432,940	W1466R	probably damaging	Het
Snai2	T	C	16: 14,706,774	L48P	possibly damaging	Het
Stt3a	A	G	9: 36,763,331		probably null	Het
Synj1	T	A	16: 90,938,430	N1545I	probably benign	Het
Vav2	A	T	2: 27,275,029	S607T	possibly damaging	Het
Wdr27	T	C	17: 14,934,575	K27E	possibly damaging	Het
Xcl1	A	T	1: 164,935,435	V19E	unknown	Het
Xlr3c	A	T	X: 73,257,634		probably null	Het
Zbtb44	T	A	9: 31,053,457	D54E	probably benign	Het

Other mutations in Zscan21

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00775:Zscan21	APN	5	138133048	nonsense	probably null
IGL02348:Zscan21	APN	5	138133383	missense	probably damaging	0.99
R0454:Zscan21	UTSW	5	138133603	missense	possibly damaging	0.77
R0471:Zscan21	UTSW	5	138125140	missense	probably benign	0.33
R1465:Zscan21	UTSW	5	138125208	missense	probably benign	0.18
R1465:Zscan21	UTSW	5	138125208	missense	probably benign	0.18
R1860:Zscan21	UTSW	5	138126630	missense	probably benign	0.00
R5498:Zscan21	UTSW	5	138133260	missense	probably benign
R5851:Zscan21	UTSW	5	138126478	missense	probably benign	0.39
R6213:Zscan21	UTSW	5	138125097	missense	probably benign	0.09
R7079:Zscan21	UTSW	5	138126466	missense	probably benign	0.11
R7448:Zscan21	UTSW	5	138117848	start gained	probably benign

Posted On

2016-08-02