Incidental Mutation 'IGL03302:Ccl24'
ID416253
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl24
Ensembl Gene ENSMUSG00000004814
Gene Namechemokine (C-C motif) ligand 24
Synonymseotaxin-2, CKb-6, Scya24, MPIF-2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03302
Quality Score
Status
Chromosome5
Chromosomal Location135569937-135573049 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 135570878 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 93 (K93E)
Ref Sequence ENSEMBL: ENSMUSP00000144002 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004936] [ENSMUST00000201401]
Predicted Effect probably benign
Transcript: ENSMUST00000004936
AA Change: K93E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000004936
Gene: ENSMUSG00000004814
AA Change: K93E

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201401
AA Change: K93E

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000144002
Gene: ENSMUSG00000004814
AA Change: K93E

DomainStartEndE-ValueType
low complexity region 8 20 N/A INTRINSIC
SCY 30 89 3.57e-24 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutant mice are born at the expected Mendelian frequency and appear healthy and normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b T A 11: 109,967,750 Y542F possibly damaging Het
Ankrd34b A T 13: 92,439,643 N461I possibly damaging Het
Ccr9 T A 9: 123,779,536 D94E probably damaging Het
Cd79a G A 7: 24,899,334 V103M probably damaging Het
Ces1e A G 8: 93,223,893 probably null Het
Cul9 T C 17: 46,526,640 E993G probably damaging Het
Cyp4a14 T C 4: 115,491,378 I330V probably benign Het
Cyp7a1 T C 4: 6,273,801 D35G probably benign Het
Dmpk C A 7: 19,086,486 probably benign Het
Gcnt1 G T 19: 17,329,183 R393S probably benign Het
Lctl C T 9: 64,134,848 probably benign Het
Mttp A T 3: 138,104,707 I664N possibly damaging Het
Myh1 C T 11: 67,211,502 A873V probably benign Het
Nedd9 A G 13: 41,338,854 V54A probably damaging Het
Olfr1306 A T 2: 111,912,822 V36E possibly damaging Het
Olfr401 T G 11: 74,121,633 C115G possibly damaging Het
Olfr449 G T 6: 42,838,003 E41* probably null Het
Pak6 A T 2: 118,693,303 E313V probably benign Het
Pla2g4a A G 1: 149,864,947 S402P probably benign Het
Polq T C 16: 37,071,772 M2012T probably damaging Het
Ppp1r12b A T 1: 134,838,050 probably benign Het
Rbp3 A G 14: 33,954,659 H188R probably damaging Het
Rps6ka2 C A 17: 7,299,388 Q682K possibly damaging Het
Scgb2b7 A T 7: 31,705,081 C65S probably damaging Het
Spag4 A G 2: 156,068,420 Q322R probably damaging Het
Spef2 T C 15: 9,676,380 T702A probably benign Het
Taf3 G T 2: 9,952,131 F408L probably damaging Het
Tead2 T G 7: 45,232,899 Y121D possibly damaging Het
Thegl T G 5: 77,054,576 S281R probably benign Het
Tmco5 A T 2: 116,892,279 T294S probably damaging Het
Trim37 A G 11: 87,147,001 E187G possibly damaging Het
Ubb T A 11: 62,552,417 L91Q probably damaging Het
Ugt2a3 G A 5: 87,336,580 P195L probably damaging Het
Zan T C 5: 137,468,390 S402G possibly damaging Het
Zc3h7a T A 16: 11,141,710 H793L probably damaging Het
Zfhx4 C T 3: 5,403,713 T2977I possibly damaging Het
Other mutations in Ccl24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4779:Ccl24 UTSW 5 135572957 missense possibly damaging 0.74
R5139:Ccl24 UTSW 5 135572921 missense probably benign 0.02
R7391:Ccl24 UTSW 5 135570822 missense possibly damaging 0.67
Posted On2016-08-02