Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03303:Mnd1'

416279

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mnd1

Ensembl Gene

ENSMUSG00000033752

Gene Name

meiotic nuclear divisions 1

Synonyms

2610034E18Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03303

Quality Score

Status

Chromosome

Chromosomal Location

83995240-84063084 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 84012244 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 155 (I155T)

Ref Sequence

ENSEMBL: ENSMUSP00000048262 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000047368]

AlphaFold

Q8K396

Predicted Effect

probably benign
Transcript: ENSMUST00000047368
AA Change: I155T

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000048262
Gene: ENSMUSG00000033752
AA Change: I155T

Domain	Start	End	E-Value	Type
Pfam:Penicillinase_R	10	129	6.9e-8	PFAM
Pfam:Mnd1	16	202	1.7e-76	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous mutants for this allele display defects in homologous chromosome synapsis and double-strand break repair. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,644,122 (GRCm39)	V940E	probably damaging	Het
Agap1	T	A	1: 89,592,874 (GRCm39)	V307D	probably damaging	Het
Amd1	A	G	10: 40,166,121 (GRCm39)	V286A	possibly damaging	Het
Bltp1	A	G	3: 36,924,226 (GRCm39)	E17G	possibly damaging	Het
Chrne	T	C	11: 70,505,926 (GRCm39)	K453R	possibly damaging	Het
Ckm	T	A	7: 19,148,263 (GRCm39)		probably benign	Het
Ckmt1	A	G	2: 121,190,486 (GRCm39)	T138A	probably benign	Het
Cldn4	A	G	5: 134,975,103 (GRCm39)	V166A	possibly damaging	Het
Dclre1a	T	C	19: 56,535,198 (GRCm39)	T129A	possibly damaging	Het
Dlgap2	T	A	8: 14,777,812 (GRCm39)	D352E	probably damaging	Het
Dnmt1	A	G	9: 20,838,006 (GRCm39)	I236T	probably benign	Het
Enam	G	T	5: 88,652,450 (GRCm39)	V1320L	probably benign	Het
Ezh1	A	C	11: 101,086,497 (GRCm39)		probably null	Het
F13b	A	T	1: 139,440,774 (GRCm39)	D410V	possibly damaging	Het
Fcrl6	A	T	1: 172,425,255 (GRCm39)	Y259N	probably damaging	Het
Fpr-rs7	A	T	17: 20,334,001 (GRCm39)	F163Y	possibly damaging	Het
Gpihbp1	C	T	15: 75,469,827 (GRCm39)	Q181*	probably null	Het
Htr2b	T	C	1: 86,027,061 (GRCm39)		probably benign	Het
Igkv1-35	A	G	6: 69,988,635 (GRCm39)	I8T	probably benign	Het
Kcnq2	T	C	2: 180,724,182 (GRCm39)	T584A	probably benign	Het
Khdrbs3	A	G	15: 68,896,672 (GRCm39)	T111A	probably benign	Het
Krtap29-1	A	T	11: 99,869,669 (GRCm39)	C71S	probably benign	Het
Lrrc4c	A	T	2: 97,459,937 (GRCm39)	I188F	probably damaging	Het
Med1	G	T	11: 98,049,178 (GRCm39)	N539K	probably damaging	Het
Mga	T	A	2: 119,733,933 (GRCm39)	D260E	probably damaging	Het
Msrb3	T	C	10: 120,620,046 (GRCm39)	D91G	probably benign	Het
Mycbp2	A	T	14: 103,485,194 (GRCm39)	D1102E	probably damaging	Het
Nfx1	T	A	4: 41,004,323 (GRCm39)		probably benign	Het
Nrsn2	T	C	2: 152,216,131 (GRCm39)	D24G	possibly damaging	Het
Or4c127	A	T	2: 89,832,810 (GRCm39)	K20I	possibly damaging	Het
Osmr	T	A	15: 6,872,289 (GRCm39)	R268S	probably benign	Het
Pelo	C	A	13: 115,225,197 (GRCm39)	V343L	probably damaging	Het
Rp1	T	A	1: 4,415,040 (GRCm39)	N2024I	probably damaging	Het
Rps6ka2	C	T	17: 7,495,411 (GRCm39)	Q33*	probably null	Het
Slfn2	G	A	11: 82,960,293 (GRCm39)	V91I	possibly damaging	Het
Socs6	G	T	18: 88,887,868 (GRCm39)	A349E	probably damaging	Het
Syt2	A	G	1: 134,669,649 (GRCm39)	N97D	probably benign	Het
Tas2r123	T	A	6: 132,824,401 (GRCm39)	H99Q	probably damaging	Het
Tmc3	A	G	7: 83,239,933 (GRCm39)		probably benign	Het
Ube2s	A	T	7: 4,813,476 (GRCm39)	V35D	probably damaging	Het
Usp32	A	T	11: 84,913,658 (GRCm39)	V891D	probably damaging	Het
Vmn1r169	A	T	7: 23,277,434 (GRCm39)	E275D	probably benign	Het
Vps13c	A	G	9: 67,841,786 (GRCm39)	H1936R	probably benign	Het
Wrap73	C	A	4: 154,231,000 (GRCm39)	A92E	probably damaging	Het
Zfhx4	C	T	3: 5,468,410 (GRCm39)	T2856M	probably damaging	Het
Zmym1	A	T	4: 126,942,927 (GRCm39)	I487N	probably damaging	Het

Other mutations in Mnd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00486:Mnd1	APN	3	84,045,505 (GRCm39)	missense	possibly damaging	0.95
IGL01355:Mnd1	APN	3	84,023,784 (GRCm39)	missense	probably benign	0.00
IGL02413:Mnd1	APN	3	84,023,786 (GRCm39)	missense	probably benign
trinidad	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R0569:Mnd1	UTSW	3	84,012,286 (GRCm39)	missense	probably benign	0.36
R1564:Mnd1	UTSW	3	84,023,738 (GRCm39)	missense	probably benign	0.41
R2208:Mnd1	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R2211:Mnd1	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R2964:Mnd1	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R2965:Mnd1	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R3106:Mnd1	UTSW	3	84,041,416 (GRCm39)	missense	probably benign	0.30
R5496:Mnd1	UTSW	3	83,995,481 (GRCm39)	missense	probably damaging	1.00
R6319:Mnd1	UTSW	3	84,049,071 (GRCm39)	missense	possibly damaging	0.95
R8805:Mnd1	UTSW	3	83,995,432 (GRCm39)	missense	probably benign	0.13
RF027:Mnd1	UTSW	3	84,041,366 (GRCm39)	missense	possibly damaging	0.95
X0026:Mnd1	UTSW	3	84,000,865 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02