Incidental Mutation 'IGL03303:Fpr-rs7'
ID 416284
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fpr-rs7
Ensembl Gene ENSMUSG00000071276
Gene Name formyl peptide receptor, related sequence 7
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock # IGL03303
Quality Score
Status
Chromosome 17
Chromosomal Location 20113210-20114226 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20113739 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 163 (F163Y)
Ref Sequence ENSEMBL: ENSMUSP00000093297 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095637]
AlphaFold Q71MR7
Predicted Effect possibly damaging
Transcript: ENSMUST00000095637
AA Change: F163Y

PolyPhen 2 Score 0.546 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000093297
Gene: ENSMUSG00000071276
AA Change: F163Y

DomainStartEndE-ValueType
Pfam:7tm_1 43 297 1.2e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176711
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 36,870,077 E17G possibly damaging Het
A2m T A 6: 121,667,163 V940E probably damaging Het
Agap1 T A 1: 89,665,152 V307D probably damaging Het
Amd1 A G 10: 40,290,125 V286A possibly damaging Het
Chrne T C 11: 70,615,100 K453R possibly damaging Het
Ckm T A 7: 19,414,338 probably benign Het
Ckmt1 A G 2: 121,360,005 T138A probably benign Het
Cldn4 A G 5: 134,946,249 V166A possibly damaging Het
Dclre1a T C 19: 56,546,766 T129A possibly damaging Het
Dlgap2 T A 8: 14,727,812 D352E probably damaging Het
Dnmt1 A G 9: 20,926,710 I236T probably benign Het
Enam G T 5: 88,504,591 V1320L probably benign Het
Ezh1 A C 11: 101,195,671 probably null Het
F13b A T 1: 139,513,036 D410V possibly damaging Het
Fcrl6 A T 1: 172,597,688 Y259N probably damaging Het
Gpihbp1 C T 15: 75,597,978 Q181* probably null Het
Htr2b T C 1: 86,099,339 probably benign Het
Igkv1-35 A G 6: 70,011,651 I8T probably benign Het
Kcnq2 T C 2: 181,082,389 T584A probably benign Het
Khdrbs3 A G 15: 69,024,823 T111A probably benign Het
Krtap29-1 A T 11: 99,978,843 C71S probably benign Het
Lrrc4c A T 2: 97,629,592 I188F probably damaging Het
Med1 G T 11: 98,158,352 N539K probably damaging Het
Mga T A 2: 119,903,452 D260E probably damaging Het
Mnd1 A G 3: 84,104,937 I155T probably benign Het
Msrb3 T C 10: 120,784,141 D91G probably benign Het
Mycbp2 A T 14: 103,247,758 D1102E probably damaging Het
Nfx1 T A 4: 41,004,323 probably benign Het
Nrsn2 T C 2: 152,374,211 D24G possibly damaging Het
Olfr1262 A T 2: 90,002,466 K20I possibly damaging Het
Osmr T A 15: 6,842,808 R268S probably benign Het
Pelo C A 13: 115,088,661 V343L probably damaging Het
Rp1 T A 1: 4,344,817 N2024I probably damaging Het
Rps6ka2 C T 17: 7,228,012 Q33* probably null Het
Slfn2 G A 11: 83,069,467 V91I possibly damaging Het
Socs6 G T 18: 88,869,744 A349E probably damaging Het
Syt2 A G 1: 134,741,911 N97D probably benign Het
Tas2r123 T A 6: 132,847,438 H99Q probably damaging Het
Tmc3 A G 7: 83,590,725 probably benign Het
Ube2s A T 7: 4,810,477 V35D probably damaging Het
Usp32 A T 11: 85,022,832 V891D probably damaging Het
Vmn1r169 A T 7: 23,578,009 E275D probably benign Het
Vps13c A G 9: 67,934,504 H1936R probably benign Het
Wrap73 C A 4: 154,146,543 A92E probably damaging Het
Zfhx4 C T 3: 5,403,350 T2856M probably damaging Het
Zmym1 A T 4: 127,049,134 I487N probably damaging Het
Other mutations in Fpr-rs7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Fpr-rs7 APN 17 20113218 nonsense probably null
IGL01386:Fpr-rs7 APN 17 20114192 missense probably damaging 0.98
IGL02293:Fpr-rs7 APN 17 20113970 missense probably benign 0.01
R0731:Fpr-rs7 UTSW 17 20113854 missense probably benign 0.00
R0826:Fpr-rs7 UTSW 17 20113626 missense probably benign 0.01
R1439:Fpr-rs7 UTSW 17 20113607 missense probably benign 0.10
R1590:Fpr-rs7 UTSW 17 20113416 missense probably benign 0.05
R1778:Fpr-rs7 UTSW 17 20114015 missense probably damaging 1.00
R4715:Fpr-rs7 UTSW 17 20113428 missense probably benign 0.00
R4744:Fpr-rs7 UTSW 17 20114003 missense probably benign 0.17
R4921:Fpr-rs7 UTSW 17 20113820 missense possibly damaging 0.70
R5540:Fpr-rs7 UTSW 17 20114094 missense probably damaging 1.00
R5677:Fpr-rs7 UTSW 17 20114103 missense probably benign
R5959:Fpr-rs7 UTSW 17 20113749 missense probably benign 0.01
R6042:Fpr-rs7 UTSW 17 20113215 missense probably benign 0.00
R7921:Fpr-rs7 UTSW 17 20113405 missense probably benign 0.03
R7984:Fpr-rs7 UTSW 17 20113409 missense probably benign 0.01
R8137:Fpr-rs7 UTSW 17 20113793 missense possibly damaging 0.49
R8172:Fpr-rs7 UTSW 17 20114181 missense probably benign 0.04
R8762:Fpr-rs7 UTSW 17 20113527 missense probably benign 0.07
R9134:Fpr-rs7 UTSW 17 20114063 missense probably damaging 1.00
Z1176:Fpr-rs7 UTSW 17 20113393 missense probably benign 0.02
Posted On 2016-08-02