Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03303:Tas2r123'

416285

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r123

Ensembl Gene

ENSMUSG00000057381

Gene Name

taste receptor, type 2, member 123

Synonyms

mt2r55, Tas2r23, STC 9-2, mGR23, T2R23

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL03303

Quality Score

Status

Chromosome

Chromosomal Location

132847142-132848143 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132847438 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 99 (H99Q)

Ref Sequence

ENSEMBL: ENSMUSP00000071615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071696]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071696
AA Change: H99Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: H99Q

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	322	4.6e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	G	3: 36,870,077	E17G	possibly damaging	Het
A2m	T	A	6: 121,667,163	V940E	probably damaging	Het
Agap1	T	A	1: 89,665,152	V307D	probably damaging	Het
Amd1	A	G	10: 40,290,125	V286A	possibly damaging	Het
Chrne	T	C	11: 70,615,100	K453R	possibly damaging	Het
Ckm	T	A	7: 19,414,338		probably benign	Het
Ckmt1	A	G	2: 121,360,005	T138A	probably benign	Het
Cldn4	A	G	5: 134,946,249	V166A	possibly damaging	Het
Dclre1a	T	C	19: 56,546,766	T129A	possibly damaging	Het
Dlgap2	T	A	8: 14,727,812	D352E	probably damaging	Het
Dnmt1	A	G	9: 20,926,710	I236T	probably benign	Het
Enam	G	T	5: 88,504,591	V1320L	probably benign	Het
Ezh1	A	C	11: 101,195,671		probably null	Het
F13b	A	T	1: 139,513,036	D410V	possibly damaging	Het
Fcrl6	A	T	1: 172,597,688	Y259N	probably damaging	Het
Fpr-rs7	A	T	17: 20,113,739	F163Y	possibly damaging	Het
Gpihbp1	C	T	15: 75,597,978	Q181*	probably null	Het
Htr2b	T	C	1: 86,099,339		probably benign	Het
Igkv1-35	A	G	6: 70,011,651	I8T	probably benign	Het
Kcnq2	T	C	2: 181,082,389	T584A	probably benign	Het
Khdrbs3	A	G	15: 69,024,823	T111A	probably benign	Het
Krtap29-1	A	T	11: 99,978,843	C71S	probably benign	Het
Lrrc4c	A	T	2: 97,629,592	I188F	probably damaging	Het
Med1	G	T	11: 98,158,352	N539K	probably damaging	Het
Mga	T	A	2: 119,903,452	D260E	probably damaging	Het
Mnd1	A	G	3: 84,104,937	I155T	probably benign	Het
Msrb3	T	C	10: 120,784,141	D91G	probably benign	Het
Mycbp2	A	T	14: 103,247,758	D1102E	probably damaging	Het
Nfx1	T	A	4: 41,004,323		probably benign	Het
Nrsn2	T	C	2: 152,374,211	D24G	possibly damaging	Het
Olfr1262	A	T	2: 90,002,466	K20I	possibly damaging	Het
Osmr	T	A	15: 6,842,808	R268S	probably benign	Het
Pelo	C	A	13: 115,088,661	V343L	probably damaging	Het
Rp1	T	A	1: 4,344,817	N2024I	probably damaging	Het
Rps6ka2	C	T	17: 7,228,012	Q33*	probably null	Het
Slfn2	G	A	11: 83,069,467	V91I	possibly damaging	Het
Socs6	G	T	18: 88,869,744	A349E	probably damaging	Het
Syt2	A	G	1: 134,741,911	N97D	probably benign	Het
Tmc3	A	G	7: 83,590,725		probably benign	Het
Ube2s	A	T	7: 4,810,477	V35D	probably damaging	Het
Usp32	A	T	11: 85,022,832	V891D	probably damaging	Het
Vmn1r169	A	T	7: 23,578,009	E275D	probably benign	Het
Vps13c	A	G	9: 67,934,504	H1936R	probably benign	Het
Wrap73	C	A	4: 154,146,543	A92E	probably damaging	Het
Zfhx4	C	T	3: 5,403,350	T2856M	probably damaging	Het
Zmym1	A	T	4: 127,049,134	I487N	probably damaging	Het

Other mutations in Tas2r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01021:Tas2r123	APN	6	132847406	missense	probably benign	0.01
IGL01547:Tas2r123	APN	6	132847458	missense	probably damaging	1.00
IGL02576:Tas2r123	APN	6	132847740	missense	possibly damaging	0.96
R0068:Tas2r123	UTSW	6	132847992	missense	possibly damaging	0.66
R0068:Tas2r123	UTSW	6	132847992	missense	possibly damaging	0.66
R0110:Tas2r123	UTSW	6	132847332	missense	probably benign	0.01
R0364:Tas2r123	UTSW	6	132847681	missense	probably benign
R0415:Tas2r123	UTSW	6	132847838	missense	probably damaging	0.97
R0469:Tas2r123	UTSW	6	132847332	missense	probably benign	0.01
R1791:Tas2r123	UTSW	6	132847565	missense	probably damaging	1.00
R1976:Tas2r123	UTSW	6	132847332	missense	probably damaging	0.96
R2328:Tas2r123	UTSW	6	132847316	missense	probably benign	0.02
R4282:Tas2r123	UTSW	6	132848045	missense	possibly damaging	0.75
R4283:Tas2r123	UTSW	6	132848045	missense	possibly damaging	0.75
R4939:Tas2r123	UTSW	6	132847845	missense	probably benign	0.32
R5079:Tas2r123	UTSW	6	132847718	missense	probably benign	0.01
R5241:Tas2r123	UTSW	6	132847218	missense	probably benign	0.06
R5288:Tas2r123	UTSW	6	132847227	missense	probably benign	0.17
R5851:Tas2r123	UTSW	6	132847308	missense	probably damaging	1.00
R6725:Tas2r123	UTSW	6	132847838	missense	probably damaging	0.97
R6895:Tas2r123	UTSW	6	132847170	missense	probably benign
R7017:Tas2r123	UTSW	6	132847550	missense	probably benign	0.00
R7183:Tas2r123	UTSW	6	132847698	missense	possibly damaging	0.95

Posted On

2016-08-02