Incidental Mutation 'IGL03303:Tas2r123'
ID416285
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tas2r123
Ensembl Gene ENSMUSG00000057381
Gene Nametaste receptor, type 2, member 123
Synonymsmt2r55, Tas2r23, STC 9-2, mGR23, T2R23
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL03303
Quality Score
Status
Chromosome6
Chromosomal Location132847142-132848143 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 132847438 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 99 (H99Q)
Ref Sequence ENSEMBL: ENSMUSP00000071615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071696]
Predicted Effect probably damaging
Transcript: ENSMUST00000071696
AA Change: H99Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: H99Q

DomainStartEndE-ValueType
Pfam:TAS2R 7 322 4.6e-79 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik A G 3: 36,870,077 E17G possibly damaging Het
A2m T A 6: 121,667,163 V940E probably damaging Het
Agap1 T A 1: 89,665,152 V307D probably damaging Het
Amd1 A G 10: 40,290,125 V286A possibly damaging Het
Chrne T C 11: 70,615,100 K453R possibly damaging Het
Ckm T A 7: 19,414,338 probably benign Het
Ckmt1 A G 2: 121,360,005 T138A probably benign Het
Cldn4 A G 5: 134,946,249 V166A possibly damaging Het
Dclre1a T C 19: 56,546,766 T129A possibly damaging Het
Dlgap2 T A 8: 14,727,812 D352E probably damaging Het
Dnmt1 A G 9: 20,926,710 I236T probably benign Het
Enam G T 5: 88,504,591 V1320L probably benign Het
Ezh1 A C 11: 101,195,671 probably null Het
F13b A T 1: 139,513,036 D410V possibly damaging Het
Fcrl6 A T 1: 172,597,688 Y259N probably damaging Het
Fpr-rs7 A T 17: 20,113,739 F163Y possibly damaging Het
Gpihbp1 C T 15: 75,597,978 Q181* probably null Het
Htr2b T C 1: 86,099,339 probably benign Het
Igkv1-35 A G 6: 70,011,651 I8T probably benign Het
Kcnq2 T C 2: 181,082,389 T584A probably benign Het
Khdrbs3 A G 15: 69,024,823 T111A probably benign Het
Krtap29-1 A T 11: 99,978,843 C71S probably benign Het
Lrrc4c A T 2: 97,629,592 I188F probably damaging Het
Med1 G T 11: 98,158,352 N539K probably damaging Het
Mga T A 2: 119,903,452 D260E probably damaging Het
Mnd1 A G 3: 84,104,937 I155T probably benign Het
Msrb3 T C 10: 120,784,141 D91G probably benign Het
Mycbp2 A T 14: 103,247,758 D1102E probably damaging Het
Nfx1 T A 4: 41,004,323 probably benign Het
Nrsn2 T C 2: 152,374,211 D24G possibly damaging Het
Olfr1262 A T 2: 90,002,466 K20I possibly damaging Het
Osmr T A 15: 6,842,808 R268S probably benign Het
Pelo C A 13: 115,088,661 V343L probably damaging Het
Rp1 T A 1: 4,344,817 N2024I probably damaging Het
Rps6ka2 C T 17: 7,228,012 Q33* probably null Het
Slfn2 G A 11: 83,069,467 V91I possibly damaging Het
Socs6 G T 18: 88,869,744 A349E probably damaging Het
Syt2 A G 1: 134,741,911 N97D probably benign Het
Tmc3 A G 7: 83,590,725 probably benign Het
Ube2s A T 7: 4,810,477 V35D probably damaging Het
Usp32 A T 11: 85,022,832 V891D probably damaging Het
Vmn1r169 A T 7: 23,578,009 E275D probably benign Het
Vps13c A G 9: 67,934,504 H1936R probably benign Het
Wrap73 C A 4: 154,146,543 A92E probably damaging Het
Zfhx4 C T 3: 5,403,350 T2856M probably damaging Het
Zmym1 A T 4: 127,049,134 I487N probably damaging Het
Other mutations in Tas2r123
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01021:Tas2r123 APN 6 132847406 missense probably benign 0.01
IGL01547:Tas2r123 APN 6 132847458 missense probably damaging 1.00
IGL02576:Tas2r123 APN 6 132847740 missense possibly damaging 0.96
R0068:Tas2r123 UTSW 6 132847992 missense possibly damaging 0.66
R0068:Tas2r123 UTSW 6 132847992 missense possibly damaging 0.66
R0110:Tas2r123 UTSW 6 132847332 missense probably benign 0.01
R0364:Tas2r123 UTSW 6 132847681 missense probably benign
R0415:Tas2r123 UTSW 6 132847838 missense probably damaging 0.97
R0469:Tas2r123 UTSW 6 132847332 missense probably benign 0.01
R1791:Tas2r123 UTSW 6 132847565 missense probably damaging 1.00
R1976:Tas2r123 UTSW 6 132847332 missense probably damaging 0.96
R2328:Tas2r123 UTSW 6 132847316 missense probably benign 0.02
R4282:Tas2r123 UTSW 6 132848045 missense possibly damaging 0.75
R4283:Tas2r123 UTSW 6 132848045 missense possibly damaging 0.75
R4939:Tas2r123 UTSW 6 132847845 missense probably benign 0.32
R5079:Tas2r123 UTSW 6 132847718 missense probably benign 0.01
R5241:Tas2r123 UTSW 6 132847218 missense probably benign 0.06
R5288:Tas2r123 UTSW 6 132847227 missense probably benign 0.17
R5851:Tas2r123 UTSW 6 132847308 missense probably damaging 1.00
R6725:Tas2r123 UTSW 6 132847838 missense probably damaging 0.97
R6895:Tas2r123 UTSW 6 132847170 missense probably benign
R7017:Tas2r123 UTSW 6 132847550 missense probably benign 0.00
R7183:Tas2r123 UTSW 6 132847698 missense possibly damaging 0.95
Posted On2016-08-02