Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03303:Tas2r123'

416285

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tas2r123

Ensembl Gene

ENSMUSG00000057381

Gene Name

taste receptor, type 2, member 123

Synonyms

mt2r55, mGR23, STC 9-2, T2R23, Tas2r23

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL03303

Quality Score

Status

Chromosome

Chromosomal Location

132824105-132825106 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132824401 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 99 (H99Q)

Ref Sequence

ENSEMBL: ENSMUSP00000071615 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071696]

AlphaFold

P59528

Predicted Effect

probably damaging
Transcript: ENSMUST00000071696
AA Change: H99Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071615
Gene: ENSMUSG00000057381
AA Change: H99Q

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	322	4.6e-79	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,644,122 (GRCm39)	V940E	probably damaging	Het
Agap1	T	A	1: 89,592,874 (GRCm39)	V307D	probably damaging	Het
Amd1	A	G	10: 40,166,121 (GRCm39)	V286A	possibly damaging	Het
Bltp1	A	G	3: 36,924,226 (GRCm39)	E17G	possibly damaging	Het
Chrne	T	C	11: 70,505,926 (GRCm39)	K453R	possibly damaging	Het
Ckm	T	A	7: 19,148,263 (GRCm39)		probably benign	Het
Ckmt1	A	G	2: 121,190,486 (GRCm39)	T138A	probably benign	Het
Cldn4	A	G	5: 134,975,103 (GRCm39)	V166A	possibly damaging	Het
Dclre1a	T	C	19: 56,535,198 (GRCm39)	T129A	possibly damaging	Het
Dlgap2	T	A	8: 14,777,812 (GRCm39)	D352E	probably damaging	Het
Dnmt1	A	G	9: 20,838,006 (GRCm39)	I236T	probably benign	Het
Enam	G	T	5: 88,652,450 (GRCm39)	V1320L	probably benign	Het
Ezh1	A	C	11: 101,086,497 (GRCm39)		probably null	Het
F13b	A	T	1: 139,440,774 (GRCm39)	D410V	possibly damaging	Het
Fcrl6	A	T	1: 172,425,255 (GRCm39)	Y259N	probably damaging	Het
Fpr-rs7	A	T	17: 20,334,001 (GRCm39)	F163Y	possibly damaging	Het
Gpihbp1	C	T	15: 75,469,827 (GRCm39)	Q181*	probably null	Het
Htr2b	T	C	1: 86,027,061 (GRCm39)		probably benign	Het
Igkv1-35	A	G	6: 69,988,635 (GRCm39)	I8T	probably benign	Het
Kcnq2	T	C	2: 180,724,182 (GRCm39)	T584A	probably benign	Het
Khdrbs3	A	G	15: 68,896,672 (GRCm39)	T111A	probably benign	Het
Krtap29-1	A	T	11: 99,869,669 (GRCm39)	C71S	probably benign	Het
Lrrc4c	A	T	2: 97,459,937 (GRCm39)	I188F	probably damaging	Het
Med1	G	T	11: 98,049,178 (GRCm39)	N539K	probably damaging	Het
Mga	T	A	2: 119,733,933 (GRCm39)	D260E	probably damaging	Het
Mnd1	A	G	3: 84,012,244 (GRCm39)	I155T	probably benign	Het
Msrb3	T	C	10: 120,620,046 (GRCm39)	D91G	probably benign	Het
Mycbp2	A	T	14: 103,485,194 (GRCm39)	D1102E	probably damaging	Het
Nfx1	T	A	4: 41,004,323 (GRCm39)		probably benign	Het
Nrsn2	T	C	2: 152,216,131 (GRCm39)	D24G	possibly damaging	Het
Or4c127	A	T	2: 89,832,810 (GRCm39)	K20I	possibly damaging	Het
Osmr	T	A	15: 6,872,289 (GRCm39)	R268S	probably benign	Het
Pelo	C	A	13: 115,225,197 (GRCm39)	V343L	probably damaging	Het
Rp1	T	A	1: 4,415,040 (GRCm39)	N2024I	probably damaging	Het
Rps6ka2	C	T	17: 7,495,411 (GRCm39)	Q33*	probably null	Het
Slfn2	G	A	11: 82,960,293 (GRCm39)	V91I	possibly damaging	Het
Socs6	G	T	18: 88,887,868 (GRCm39)	A349E	probably damaging	Het
Syt2	A	G	1: 134,669,649 (GRCm39)	N97D	probably benign	Het
Tmc3	A	G	7: 83,239,933 (GRCm39)		probably benign	Het
Ube2s	A	T	7: 4,813,476 (GRCm39)	V35D	probably damaging	Het
Usp32	A	T	11: 84,913,658 (GRCm39)	V891D	probably damaging	Het
Vmn1r169	A	T	7: 23,277,434 (GRCm39)	E275D	probably benign	Het
Vps13c	A	G	9: 67,841,786 (GRCm39)	H1936R	probably benign	Het
Wrap73	C	A	4: 154,231,000 (GRCm39)	A92E	probably damaging	Het
Zfhx4	C	T	3: 5,468,410 (GRCm39)	T2856M	probably damaging	Het
Zmym1	A	T	4: 126,942,927 (GRCm39)	I487N	probably damaging	Het

Other mutations in Tas2r123

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01021:Tas2r123	APN	6	132,824,369 (GRCm39)	missense	probably benign	0.01
IGL01547:Tas2r123	APN	6	132,824,421 (GRCm39)	missense	probably damaging	1.00
IGL02576:Tas2r123	APN	6	132,824,703 (GRCm39)	missense	possibly damaging	0.96
G1patch:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R0068:Tas2r123	UTSW	6	132,824,955 (GRCm39)	missense	possibly damaging	0.66
R0068:Tas2r123	UTSW	6	132,824,955 (GRCm39)	missense	possibly damaging	0.66
R0110:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably benign	0.01
R0364:Tas2r123	UTSW	6	132,824,644 (GRCm39)	missense	probably benign
R0415:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R0469:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably benign	0.01
R1791:Tas2r123	UTSW	6	132,824,528 (GRCm39)	missense	probably damaging	1.00
R1976:Tas2r123	UTSW	6	132,824,295 (GRCm39)	missense	probably damaging	0.96
R2328:Tas2r123	UTSW	6	132,824,279 (GRCm39)	missense	probably benign	0.02
R4282:Tas2r123	UTSW	6	132,825,008 (GRCm39)	missense	possibly damaging	0.75
R4283:Tas2r123	UTSW	6	132,825,008 (GRCm39)	missense	possibly damaging	0.75
R4939:Tas2r123	UTSW	6	132,824,808 (GRCm39)	missense	probably benign	0.32
R5079:Tas2r123	UTSW	6	132,824,681 (GRCm39)	missense	probably benign	0.01
R5241:Tas2r123	UTSW	6	132,824,181 (GRCm39)	missense	probably benign	0.06
R5288:Tas2r123	UTSW	6	132,824,190 (GRCm39)	missense	probably benign	0.17
R5851:Tas2r123	UTSW	6	132,824,271 (GRCm39)	missense	probably damaging	1.00
R6725:Tas2r123	UTSW	6	132,824,801 (GRCm39)	missense	probably damaging	0.97
R6895:Tas2r123	UTSW	6	132,824,133 (GRCm39)	missense	probably benign
R7017:Tas2r123	UTSW	6	132,824,513 (GRCm39)	missense	probably benign	0.00
R7183:Tas2r123	UTSW	6	132,824,661 (GRCm39)	missense	possibly damaging	0.95
R8972:Tas2r123	UTSW	6	132,824,333 (GRCm39)	missense	probably benign	0.30
R9321:Tas2r123	UTSW	6	132,825,095 (GRCm39)	missense	probably benign

Posted On

2016-08-02