Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03303:Zmym1'

416312

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zmym1

Ensembl Gene

ENSMUSG00000043872

Gene Name

zinc finger, MYM domain containing 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.226) question?

Stock #

IGL03303

Quality Score

Status

Chromosome

Chromosomal Location

127047094-127061152 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 127049134 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 487 (I487N)

Ref Sequence

ENSEMBL: ENSMUSP00000101708 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055013] [ENSMUST00000106099] [ENSMUST00000106102]

AlphaFold

Q3TJB1

Predicted Effect

probably damaging
Transcript: ENSMUST00000055013
AA Change: I487N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000050669
Gene: ENSMUSG00000043872
AA Change: I487N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	2.4e-8	PFAM
Pfam:zf-FCS	53	96	1.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	4.9e-55	PFAM
Pfam:Dimer_Tnp_hAT	870	959	5.1e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000106099
AA Change: I389N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101705
Gene: ENSMUSG00000043872
AA Change: I389N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	3.3e-9	PFAM
Pfam:zf-FCS	53	96	4.6e-10	PFAM
low complexity region	155	168	N/A	INTRINSIC
Pfam:DUF4371	237	471	2.8e-52	PFAM
Pfam:Dimer_Tnp_hAT	772	861	5.3e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000106102
AA Change: I487N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101708
Gene: ENSMUSG00000043872
AA Change: I487N

Domain	Start	End	E-Value	Type
Pfam:zf-FCS	6	46	7.8e-9	PFAM
Pfam:zf-FCS	53	96	1.1e-9	PFAM
low complexity region	155	168	N/A	INTRINSIC
low complexity region	229	243	N/A	INTRINSIC
Pfam:DUF4371	335	569	7.4e-52	PFAM
Pfam:Dimer_Tnp_hAT	870	959	1.7e-17	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000117934

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124429

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137236

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152607

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	A	G	3: 36,870,077	E17G	possibly damaging	Het
A2m	T	A	6: 121,667,163	V940E	probably damaging	Het
Agap1	T	A	1: 89,665,152	V307D	probably damaging	Het
Amd1	A	G	10: 40,290,125	V286A	possibly damaging	Het
Chrne	T	C	11: 70,615,100	K453R	possibly damaging	Het
Ckm	T	A	7: 19,414,338		probably benign	Het
Ckmt1	A	G	2: 121,360,005	T138A	probably benign	Het
Cldn4	A	G	5: 134,946,249	V166A	possibly damaging	Het
Dclre1a	T	C	19: 56,546,766	T129A	possibly damaging	Het
Dlgap2	T	A	8: 14,727,812	D352E	probably damaging	Het
Dnmt1	A	G	9: 20,926,710	I236T	probably benign	Het
Enam	G	T	5: 88,504,591	V1320L	probably benign	Het
Ezh1	A	C	11: 101,195,671		probably null	Het
F13b	A	T	1: 139,513,036	D410V	possibly damaging	Het
Fcrl6	A	T	1: 172,597,688	Y259N	probably damaging	Het
Fpr-rs7	A	T	17: 20,113,739	F163Y	possibly damaging	Het
Gpihbp1	C	T	15: 75,597,978	Q181*	probably null	Het
Htr2b	T	C	1: 86,099,339		probably benign	Het
Igkv1-35	A	G	6: 70,011,651	I8T	probably benign	Het
Kcnq2	T	C	2: 181,082,389	T584A	probably benign	Het
Khdrbs3	A	G	15: 69,024,823	T111A	probably benign	Het
Krtap29-1	A	T	11: 99,978,843	C71S	probably benign	Het
Lrrc4c	A	T	2: 97,629,592	I188F	probably damaging	Het
Med1	G	T	11: 98,158,352	N539K	probably damaging	Het
Mga	T	A	2: 119,903,452	D260E	probably damaging	Het
Mnd1	A	G	3: 84,104,937	I155T	probably benign	Het
Msrb3	T	C	10: 120,784,141	D91G	probably benign	Het
Mycbp2	A	T	14: 103,247,758	D1102E	probably damaging	Het
Nfx1	T	A	4: 41,004,323		probably benign	Het
Nrsn2	T	C	2: 152,374,211	D24G	possibly damaging	Het
Olfr1262	A	T	2: 90,002,466	K20I	possibly damaging	Het
Osmr	T	A	15: 6,842,808	R268S	probably benign	Het
Pelo	C	A	13: 115,088,661	V343L	probably damaging	Het
Rp1	T	A	1: 4,344,817	N2024I	probably damaging	Het
Rps6ka2	C	T	17: 7,228,012	Q33*	probably null	Het
Slfn2	G	A	11: 83,069,467	V91I	possibly damaging	Het
Socs6	G	T	18: 88,869,744	A349E	probably damaging	Het
Syt2	A	G	1: 134,741,911	N97D	probably benign	Het
Tas2r123	T	A	6: 132,847,438	H99Q	probably damaging	Het
Tmc3	A	G	7: 83,590,725		probably benign	Het
Ube2s	A	T	7: 4,810,477	V35D	probably damaging	Het
Usp32	A	T	11: 85,022,832	V891D	probably damaging	Het
Vmn1r169	A	T	7: 23,578,009	E275D	probably benign	Het
Vps13c	A	G	9: 67,934,504	H1936R	probably benign	Het
Wrap73	C	A	4: 154,146,543	A92E	probably damaging	Het
Zfhx4	C	T	3: 5,403,350	T2856M	probably damaging	Het

Other mutations in Zmym1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01140:Zmym1	APN	4	127049642	missense	probably damaging	1.00
IGL02326:Zmym1	APN	4	127047760	missense	probably damaging	1.00
IGL02392:Zmym1	APN	4	127048463	missense	probably damaging	1.00
IGL02431:Zmym1	APN	4	127047764	nonsense	probably null
IGL02512:Zmym1	APN	4	127048672	missense	probably damaging	1.00
BB009:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
BB019:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
R0195:Zmym1	UTSW	4	127047911	missense	possibly damaging	0.85
R0266:Zmym1	UTSW	4	127048025	missense	possibly damaging	0.86
R0416:Zmym1	UTSW	4	127058820	missense	probably benign	0.00
R1374:Zmym1	UTSW	4	127049611	missense	probably damaging	1.00
R1480:Zmym1	UTSW	4	127048612	missense	probably damaging	0.99
R1704:Zmym1	UTSW	4	127048384	missense	probably damaging	1.00
R1806:Zmym1	UTSW	4	127048079	missense	probably damaging	1.00
R1815:Zmym1	UTSW	4	127049021	missense	possibly damaging	0.76
R2124:Zmym1	UTSW	4	127049570	missense	probably benign	0.05
R2169:Zmym1	UTSW	4	127054203	splice site	probably null
R4027:Zmym1	UTSW	4	127049879	missense	probably benign	0.08
R4410:Zmym1	UTSW	4	127048104	nonsense	probably null
R4572:Zmym1	UTSW	4	127050835	missense	probably benign	0.39
R4788:Zmym1	UTSW	4	127054297	missense	probably benign	0.10
R5120:Zmym1	UTSW	4	127051437	splice site	probably null
R5130:Zmym1	UTSW	4	127048658	missense	probably damaging	1.00
R5615:Zmym1	UTSW	4	127049398	missense	probably damaging	1.00
R6190:Zmym1	UTSW	4	127047884	missense	probably damaging	0.99
R7426:Zmym1	UTSW	4	127049398	missense	possibly damaging	0.81
R7464:Zmym1	UTSW	4	127058935	nonsense	probably null
R7540:Zmym1	UTSW	4	127048757	missense	probably benign
R7779:Zmym1	UTSW	4	127054245	missense	probably benign
R7807:Zmym1	UTSW	4	127047874	missense	probably damaging	1.00
R7876:Zmym1	UTSW	4	127047703	missense	probably damaging	0.98
R7932:Zmym1	UTSW	4	127050785	missense	possibly damaging	0.77
R8183:Zmym1	UTSW	4	127058856	missense	probably benign	0.07
R8276:Zmym1	UTSW	4	127054258	missense	probably damaging	0.99
R8744:Zmym1	UTSW	4	127051372	missense	probably damaging	1.00
R8798:Zmym1	UTSW	4	127049871	missense	possibly damaging	0.90
R9199:Zmym1	UTSW	4	127050830	missense	possibly damaging	0.80
R9385:Zmym1	UTSW	4	127058890	missense	probably damaging	1.00
T0722:Zmym1	UTSW	4	127047947	missense	probably benign	0.00
T0722:Zmym1	UTSW	4	127048250	missense	probably benign	0.01
T0722:Zmym1	UTSW	4	127049673	missense	probably benign	0.05
T0975:Zmym1	UTSW	4	127047947	missense	probably benign	0.00
T0975:Zmym1	UTSW	4	127048250	missense	probably benign	0.01
T0975:Zmym1	UTSW	4	127049673	missense	probably benign	0.05

Posted On

2016-08-02