Incidental Mutation 'IGL03304:Pla2g5'
ID416349
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g5
Ensembl Gene ENSMUSG00000041193
Gene Namephospholipase A2, group V
SynonymssPLA2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL03304
Quality Score
Status
Chromosome4
Chromosomal Location138799244-138863482 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 138804569 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 41 (Y41*)
Ref Sequence ENSEMBL: ENSMUSP00000099571 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030524] [ENSMUST00000102511] [ENSMUST00000102512] [ENSMUST00000102513]
Predicted Effect probably null
Transcript: ENSMUST00000030524
AA Change: Y41*
SMART Domains Protein: ENSMUSP00000030524
Gene: ENSMUSG00000041193
AA Change: Y41*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102511
AA Change: Y41*
SMART Domains Protein: ENSMUSP00000099569
Gene: ENSMUSG00000041193
AA Change: Y41*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102512
AA Change: Y41*
SMART Domains Protein: ENSMUSP00000099570
Gene: ENSMUSG00000041193
AA Change: Y41*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect probably null
Transcript: ENSMUST00000102513
AA Change: Y41*
SMART Domains Protein: ENSMUSP00000099571
Gene: ENSMUSG00000041193
AA Change: Y41*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
PA2c 21 137 1.16e-52 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127183
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136393
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140117
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154844
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik A G 7: 28,142,242 Y534C probably damaging Het
Acy1 A T 9: 106,435,466 probably null Het
Adamts4 T C 1: 171,252,869 probably benign Het
Anapc1 A T 2: 128,627,113 probably benign Het
Ank2 C A 3: 126,955,870 E503D probably damaging Het
Aoah A G 13: 20,915,010 probably benign Het
Atp9b A T 18: 80,917,877 Y40N probably damaging Het
Brd8 A G 18: 34,614,580 probably benign Het
Cd274 A C 19: 29,384,102 E270A probably damaging Het
Cic T A 7: 25,284,849 V23E probably damaging Het
Cpeb4 T C 11: 31,872,739 L151P probably damaging Het
D3Ertd751e G A 3: 41,746,729 probably null Het
Diaph1 A T 18: 37,854,573 D1043E possibly damaging Het
Hmcn1 T A 1: 150,630,231 N3848I probably damaging Het
Ifi211 A T 1: 173,907,707 M52K probably damaging Het
Itih4 T C 14: 30,898,049 I747T probably damaging Het
Kif1bp A C 10: 62,559,303 L520R probably damaging Het
Lcat T C 8: 105,940,063 M276V possibly damaging Het
Mmp1b A T 9: 7,384,701 D282E probably damaging Het
Mst1r T A 9: 107,907,938 V265D probably damaging Het
Muc4 T A 16: 32,751,439 L439* probably null Het
Nlrp4e T A 7: 23,353,343 probably null Het
Ogfod2 A T 5: 124,112,823 D24V probably damaging Het
Olfr1413 T C 1: 92,573,303 V44A probably benign Het
Olfr1458 A G 19: 13,102,741 S182P probably damaging Het
Olfr356 T C 2: 36,937,548 L143P probably damaging Het
Pcnx T A 12: 81,982,029 W1661R probably damaging Het
Pdzph1 G A 17: 58,880,646 T1193I probably damaging Het
Pias3 A G 3: 96,700,031 T152A possibly damaging Het
Plxna4 A G 6: 32,165,051 probably benign Het
Ppp2r2a A C 14: 67,016,528 V397G probably benign Het
Ripor3 A G 2: 167,980,928 probably benign Het
Slc35a3 A G 3: 116,687,311 L101P probably damaging Het
Sptan1 G A 2: 29,986,493 R295Q probably damaging Het
Syce1 A T 7: 140,777,710 V314D possibly damaging Het
Tex52 T C 6: 128,379,532 Y63H possibly damaging Het
Tmem63a T A 1: 180,968,853 Y580* probably null Het
Ube2m T A 7: 13,035,758 probably benign Het
Vmn1r50 G T 6: 90,107,643 K123N probably damaging Het
Other mutations in Pla2g5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0278:Pla2g5 UTSW 4 138800656 missense probably benign 0.40
R0323:Pla2g5 UTSW 4 138800656 missense probably benign 0.40
R0325:Pla2g5 UTSW 4 138800656 missense probably benign 0.40
R3767:Pla2g5 UTSW 4 138801435 missense probably damaging 1.00
R3768:Pla2g5 UTSW 4 138801435 missense probably damaging 1.00
R3769:Pla2g5 UTSW 4 138801435 missense probably damaging 1.00
R3770:Pla2g5 UTSW 4 138801435 missense probably damaging 1.00
R5620:Pla2g5 UTSW 4 138804610 missense possibly damaging 0.83
R6776:Pla2g5 UTSW 4 138800653 missense probably benign 0.00
R7065:Pla2g5 UTSW 4 138800604 missense probably damaging 1.00
R7097:Pla2g5 UTSW 4 138804519 missense probably damaging 1.00
R7122:Pla2g5 UTSW 4 138804519 missense probably damaging 1.00
R7829:Pla2g5 UTSW 4 138804534 missense probably benign 0.26
Posted On2016-08-02