Incidental Mutation 'IGL03305:Npy6r'
ID416361
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Npy6r
Ensembl Gene ENSMUSG00000038071
Gene Nameneuropeptide Y receptor Y6
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03305
Quality Score
Status
Chromosome18
Chromosomal Location44270127-44277700 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 44275854 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 114 (Y114C)
Ref Sequence ENSEMBL: ENSMUSP00000040797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042747]
Predicted Effect probably damaging
Transcript: ENSMUST00000042747
AA Change: Y114C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000040797
Gene: ENSMUSG00000038071
AA Change: Y114C

DomainStartEndE-ValueType
low complexity region 33 41 N/A INTRINSIC
Pfam:7tm_1 52 318 3.5e-51 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a reporter allele exhibit enhanced performance on the rotarod test. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 12 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A330008L17Rik T A 8: 99,419,830 probably benign Het
Akap3 G A 6: 126,864,765 V116I probably benign Het
B4galt5 T C 2: 167,305,783 D224G probably damaging Het
Bmpr1b G T 3: 141,843,024 probably benign Het
Chmp2a T C 7: 13,032,155 K137E possibly damaging Het
Cpeb1 T C 7: 81,361,716 K159R probably benign Het
Dhx36 G A 3: 62,500,836 Q194* probably null Het
Gm4922 T A 10: 18,783,484 K497* probably null Het
Grid1 A G 14: 35,251,707 N247S probably damaging Het
Ppl A G 16: 5,093,233 V785A possibly damaging Het
Tmprss11d T C 5: 86,326,420 H88R probably damaging Het
Wdr64 G A 1: 175,755,586 V373M possibly damaging Het
Other mutations in Npy6r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00227:Npy6r APN 18 44276444 missense probably damaging 1.00
IGL00767:Npy6r APN 18 44276318 missense probably benign 0.01
IGL01103:Npy6r APN 18 44275518 missense probably benign 0.15
IGL02085:Npy6r APN 18 44275931 missense probably damaging 1.00
IGL02653:Npy6r APN 18 44276627 makesense probably null
R0588:Npy6r UTSW 18 44275821 missense possibly damaging 0.94
R1993:Npy6r UTSW 18 44276508 missense probably damaging 1.00
R2039:Npy6r UTSW 18 44276003 missense probably benign
R2567:Npy6r UTSW 18 44275821 missense possibly damaging 0.68
R4572:Npy6r UTSW 18 44275917 missense probably benign 0.03
R4584:Npy6r UTSW 18 44276195 missense probably damaging 1.00
R4611:Npy6r UTSW 18 44276401 missense probably damaging 1.00
R4741:Npy6r UTSW 18 44275724 missense probably damaging 1.00
R5145:Npy6r UTSW 18 44276619 missense probably benign 0.04
R5603:Npy6r UTSW 18 44276585 missense probably damaging 1.00
R5610:Npy6r UTSW 18 44275994 missense probably benign
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6030:Npy6r UTSW 18 44276082 missense probably benign 0.02
R6083:Npy6r UTSW 18 44276492 missense probably damaging 0.99
R6364:Npy6r UTSW 18 44276511 missense possibly damaging 0.86
R7146:Npy6r UTSW 18 44275721 missense probably benign 0.30
R7178:Npy6r UTSW 18 44276484 missense probably damaging 1.00
R7180:Npy6r UTSW 18 44276156 missense probably benign
R7203:Npy6r UTSW 18 44275932 missense probably damaging 1.00
R7448:Npy6r UTSW 18 44276193 missense probably damaging 1.00
Posted On2016-08-02