Incidental Mutation 'IGL03323:Olfr345'
ID416540
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr345
Ensembl Gene ENSMUSG00000059251
Gene Nameolfactory receptor 345
SynonymsGA_x6K02T2NLDC-33334179-33335114, MOR136-7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL03323
Quality Score
Status
Chromosome2
Chromosomal Location36640041-36640976 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 36640141 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 34 (M34K)
Ref Sequence ENSEMBL: ENSMUSP00000076122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076850]
Predicted Effect possibly damaging
Transcript: ENSMUST00000076850
AA Change: M34K

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000076122
Gene: ENSMUSG00000059251
AA Change: M34K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.6e-57 PFAM
Pfam:7tm_1 41 290 2.6e-22 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 A T 14: 103,055,294 D418V probably damaging Het
Ahdc1 G A 4: 133,065,428 G1327S probably benign Het
Bcl2l15 A T 3: 103,833,403 I62L probably benign Het
Ccdc7a A T 8: 129,058,763 D105E probably benign Het
Cldn12 C A 5: 5,508,421 G2V probably damaging Het
Eapp G T 12: 54,673,615 H272N probably damaging Het
Fcrla A G 1: 170,927,545 probably benign Het
Fmnl3 C T 15: 99,321,281 G787S probably damaging Het
Fmo5 G T 3: 97,639,007 probably null Het
Golgb1 G T 16: 36,913,453 E1021* probably null Het
Hspa4 A T 11: 53,265,133 N648K probably benign Het
Iigp1 T C 18: 60,389,824 F5L probably benign Het
Lad1 T A 1: 135,830,974 probably null Het
Man2b2 T C 5: 36,818,514 D399G probably benign Het
Mc5r C T 18: 68,339,215 T215I probably benign Het
Mx2 A G 16: 97,546,375 S156G probably damaging Het
Necap2 A T 4: 141,068,222 I242N possibly damaging Het
Nme8 C T 13: 19,688,950 E175K probably benign Het
Notch4 T A 17: 34,582,471 C1098S probably damaging Het
Olfr8 T C 10: 78,955,600 Y132H probably benign Het
Osbpl9 A G 4: 109,062,459 probably benign Het
Prag1 T C 8: 36,140,008 S968P probably damaging Het
Qsox2 A G 2: 26,220,979 S125P probably benign Het
Rptn A G 3: 93,397,153 T598A probably benign Het
Slc2a2 G A 3: 28,726,290 M375I probably damaging Het
Tmed9 C T 13: 55,596,878 T173I probably damaging Het
Trank1 A G 9: 111,352,116 D402G probably damaging Het
Ttc21a G T 9: 119,940,536 probably benign Het
Vmn2r58 T C 7: 41,861,871 M503V probably benign Het
Other mutations in Olfr345
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03399:Olfr345 APN 2 36640882 missense possibly damaging 0.78
R1164:Olfr345 UTSW 2 36640120 missense probably benign
R1878:Olfr345 UTSW 2 36640189 missense possibly damaging 0.83
R1879:Olfr345 UTSW 2 36640189 missense possibly damaging 0.83
R1954:Olfr345 UTSW 2 36640215 missense possibly damaging 0.86
R2206:Olfr345 UTSW 2 36640189 missense possibly damaging 0.83
R2207:Olfr345 UTSW 2 36640189 missense possibly damaging 0.83
R3773:Olfr345 UTSW 2 36640321 missense probably benign 0.16
R4470:Olfr345 UTSW 2 36640221 missense probably damaging 1.00
R4583:Olfr345 UTSW 2 36640614 missense probably damaging 1.00
R4744:Olfr345 UTSW 2 36640979 unclassified probably null
R4897:Olfr345 UTSW 2 36640894 missense probably damaging 1.00
R5308:Olfr345 UTSW 2 36640694 nonsense probably null
R5510:Olfr345 UTSW 2 36640963 missense probably benign
R6175:Olfr345 UTSW 2 36640051 missense probably benign 0.00
R7736:Olfr345 UTSW 2 36640185 missense probably damaging 1.00
R7737:Olfr345 UTSW 2 36640620 missense probably benign 0.01
Posted On2016-08-02