Incidental Mutation 'IGL03323:Iigp1'
ID416549
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Iigp1
Ensembl Gene ENSMUSG00000054072
Gene Nameinterferon inducible GTPase 1
Synonyms2900074L10Rik, Irga6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL03323
Quality Score
Status
Chromosome18
Chromosomal Location60376029-60392627 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 60389824 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 5 (F5L)
Ref Sequence ENSEMBL: ENSMUSP00000063390 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032473] [ENSMUST00000066912]
Predicted Effect probably benign
Transcript: ENSMUST00000032473
AA Change: F5L

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000032473
Gene: ENSMUSG00000054072
AA Change: F5L

DomainStartEndE-ValueType
Pfam:IIGP 35 409 5.5e-182 PFAM
Pfam:MMR_HSR1 71 210 1.4e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000066912
AA Change: F5L

PolyPhen 2 Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000063390
Gene: ENSMUSG00000054072
AA Change: F5L

DomainStartEndE-ValueType
Pfam:IIGP 35 409 7.9e-182 PFAM
Pfam:MMR_HSR1 71 212 8.2e-9 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acod1 A T 14: 103,055,294 D418V probably damaging Het
Ahdc1 G A 4: 133,065,428 G1327S probably benign Het
Bcl2l15 A T 3: 103,833,403 I62L probably benign Het
Ccdc7a A T 8: 129,058,763 D105E probably benign Het
Cldn12 C A 5: 5,508,421 G2V probably damaging Het
Eapp G T 12: 54,673,615 H272N probably damaging Het
Fcrla A G 1: 170,927,545 probably benign Het
Fmnl3 C T 15: 99,321,281 G787S probably damaging Het
Fmo5 G T 3: 97,639,007 probably null Het
Golgb1 G T 16: 36,913,453 E1021* probably null Het
Hspa4 A T 11: 53,265,133 N648K probably benign Het
Lad1 T A 1: 135,830,974 probably null Het
Man2b2 T C 5: 36,818,514 D399G probably benign Het
Mc5r C T 18: 68,339,215 T215I probably benign Het
Mx2 A G 16: 97,546,375 S156G probably damaging Het
Necap2 A T 4: 141,068,222 I242N possibly damaging Het
Nme8 C T 13: 19,688,950 E175K probably benign Het
Notch4 T A 17: 34,582,471 C1098S probably damaging Het
Olfr345 T A 2: 36,640,141 M34K possibly damaging Het
Olfr8 T C 10: 78,955,600 Y132H probably benign Het
Osbpl9 A G 4: 109,062,459 probably benign Het
Prag1 T C 8: 36,140,008 S968P probably damaging Het
Qsox2 A G 2: 26,220,979 S125P probably benign Het
Rptn A G 3: 93,397,153 T598A probably benign Het
Slc2a2 G A 3: 28,726,290 M375I probably damaging Het
Tmed9 C T 13: 55,596,878 T173I probably damaging Het
Trank1 A G 9: 111,352,116 D402G probably damaging Het
Ttc21a G T 9: 119,940,536 probably benign Het
Vmn2r58 T C 7: 41,861,871 M503V probably benign Het
Other mutations in Iigp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00798:Iigp1 APN 18 60391001 missense probably benign 0.01
R0025:Iigp1 UTSW 18 60390787 missense possibly damaging 0.53
R0410:Iigp1 UTSW 18 60390303 missense probably benign 0.15
R0564:Iigp1 UTSW 18 60390451 missense probably damaging 0.98
R0609:Iigp1 UTSW 18 60389824 missense probably benign 0.04
R1549:Iigp1 UTSW 18 60389876 missense probably benign
R2226:Iigp1 UTSW 18 60389888 missense possibly damaging 0.55
R2264:Iigp1 UTSW 18 60390666 missense probably benign 0.20
R3110:Iigp1 UTSW 18 60390911 missense probably benign 0.01
R3112:Iigp1 UTSW 18 60390911 missense probably benign 0.01
R4575:Iigp1 UTSW 18 60390146 missense probably benign 0.02
R4795:Iigp1 UTSW 18 60389892 missense probably benign 0.13
R5439:Iigp1 UTSW 18 60390257 missense probably damaging 1.00
R6565:Iigp1 UTSW 18 60390767 missense probably damaging 1.00
Posted On2016-08-02