|Institutional Source||Beutler Lab|
|Gene Name||solute carrier family 22 (organic cation transporter), member 3|
|Synonyms||Oct3, EMT, Orct3|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0466 (G1)|
|Chromosomal Location||12419972-12507704 bp(-) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||G to A at 12458493 bp|
|Amino Acid Change||Glutamine to Stop codon at position 263 (Q263*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000024595 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024595]|
|Predicted Effect||probably null
AA Change: Q263*
AA Change: Q263*
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||97% (63/65)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Slc22a3||
(F):5'- TGACAACTGTCAGTCAAGCAGCC -3'
(R):5'- GGAAGCCTCCATGTCCTCATGTTC -3'
(F):5'- AGCCAATAATCTCTCTAGGCTG -3'
(R):5'- ACAAGTGTCAAGTCTGTTTGC -3'