Incidental Mutation 'IGL03325:Iigp1c'
| ID |
416614 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Iigp1c
|
| Ensembl Gene |
ENSMUSG00000073555 |
| Gene Name |
interferon inducible GTPase 1C |
| Synonyms |
Gm4951 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03325
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
18 |
| Chromosomal Location |
60345152-60380892 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 60378883 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 139
(Y139*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031549
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031549]
|
| AlphaFold |
Q3UED7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000031549
AA Change: Y139*
|
| SMART Domains |
Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: Y139*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
34 |
402 |
4.8e-157 |
PFAM |
|
Pfam:MMR_HSR1
|
70 |
198 |
2.8e-8 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8b |
G |
A |
11: 109,844,422 (GRCm39) |
R870C |
possibly damaging |
Het |
| Abcf2 |
A |
T |
5: 24,779,210 (GRCm39) |
L113I |
probably damaging |
Het |
| Abi1 |
C |
T |
2: 22,861,240 (GRCm39) |
R106Q |
probably damaging |
Het |
| Arhgef28 |
A |
G |
13: 98,036,324 (GRCm39) |
V1645A |
probably benign |
Het |
| Ccdc198 |
A |
T |
14: 49,481,277 (GRCm39) |
|
probably benign |
Het |
| Ceacam1 |
G |
A |
7: 25,175,912 (GRCm39) |
A94V |
possibly damaging |
Het |
| Fat2 |
G |
A |
11: 55,173,168 (GRCm39) |
T2515I |
probably damaging |
Het |
| Gm5800 |
T |
C |
14: 51,951,983 (GRCm39) |
Y93C |
probably benign |
Het |
| Gnl1 |
A |
G |
17: 36,299,548 (GRCm39) |
D573G |
probably damaging |
Het |
| Gosr1 |
A |
G |
11: 76,645,229 (GRCm39) |
M105T |
probably benign |
Het |
| Gramd1c |
A |
T |
16: 43,825,868 (GRCm39) |
Y303N |
probably benign |
Het |
| Heatr9 |
A |
G |
11: 83,404,085 (GRCm39) |
|
probably null |
Het |
| Itih2 |
T |
C |
2: 10,111,546 (GRCm39) |
D464G |
probably damaging |
Het |
| Jcad |
T |
C |
18: 4,673,902 (GRCm39) |
Y555H |
probably benign |
Het |
| Krtap19-3 |
A |
T |
16: 88,674,609 (GRCm39) |
*88R |
probably null |
Het |
| Mrps11 |
T |
C |
7: 78,440,453 (GRCm39) |
F114S |
probably damaging |
Het |
| Nat8 |
A |
T |
6: 85,807,875 (GRCm39) |
V86E |
possibly damaging |
Het |
| Nek5 |
T |
C |
8: 22,569,158 (GRCm39) |
T555A |
probably benign |
Het |
| Or6c3 |
A |
T |
10: 129,309,474 (GRCm39) |
K304N |
probably benign |
Het |
| Pprc1 |
C |
T |
19: 46,049,948 (GRCm39) |
T10I |
possibly damaging |
Het |
| Prss16 |
A |
G |
13: 22,187,417 (GRCm39) |
V409A |
possibly damaging |
Het |
| Sema3d |
T |
A |
5: 12,513,189 (GRCm39) |
L53Q |
probably damaging |
Het |
| Sfmbt2 |
T |
C |
2: 10,582,628 (GRCm39) |
Y696H |
probably damaging |
Het |
| Sh2d3c |
C |
T |
2: 32,615,270 (GRCm39) |
A120V |
probably benign |
Het |
| Smn1 |
A |
G |
13: 100,264,365 (GRCm39) |
Y32C |
probably damaging |
Het |
| Sun2 |
C |
T |
15: 79,622,849 (GRCm39) |
R110Q |
probably benign |
Het |
| Tcp11l2 |
T |
G |
10: 84,440,764 (GRCm39) |
D323E |
possibly damaging |
Het |
| Tex55 |
A |
T |
16: 38,648,355 (GRCm39) |
S251R |
probably damaging |
Het |
| Tnni3k |
A |
T |
3: 154,667,451 (GRCm39) |
S296R |
probably damaging |
Het |
| Uck1 |
G |
A |
2: 32,148,334 (GRCm39) |
R161C |
probably benign |
Het |
| Unc79 |
T |
A |
12: 103,135,869 (GRCm39) |
S2435T |
probably damaging |
Het |
| Vmn2r114 |
C |
A |
17: 23,510,652 (GRCm39) |
K609N |
probably damaging |
Het |
|
| Other mutations in Iigp1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00717:Iigp1c
|
APN |
18 |
60,379,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Iigp1c
|
APN |
18 |
60,378,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00956:Iigp1c
|
APN |
18 |
60,379,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Iigp1c
|
APN |
18 |
60,378,508 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01929:Iigp1c
|
APN |
18 |
60,379,554 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02267:Iigp1c
|
APN |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02276:Iigp1c
|
APN |
18 |
60,379,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02499:Iigp1c
|
APN |
18 |
60,378,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02538:Iigp1c
|
APN |
18 |
60,378,944 (GRCm39) |
nonsense |
probably null |
|
|
IGL03139:Iigp1c
|
APN |
18 |
60,379,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03209:Iigp1c
|
APN |
18 |
60,379,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Iigp1c
|
APN |
18 |
60,378,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
Carboniferous
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Oily
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Iigp1c
|
UTSW |
18 |
60,378,489 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2046:Iigp1c
|
UTSW |
18 |
60,378,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2296:Iigp1c
|
UTSW |
18 |
60,378,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4583:Iigp1c
|
UTSW |
18 |
60,379,152 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5500:Iigp1c
|
UTSW |
18 |
60,379,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5532:Iigp1c
|
UTSW |
18 |
60,379,142 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5938:Iigp1c
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6446:Iigp1c
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7191:Iigp1c
|
UTSW |
18 |
60,379,329 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7238:Iigp1c
|
UTSW |
18 |
60,379,355 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7443:Iigp1c
|
UTSW |
18 |
60,379,122 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9261:Iigp1c
|
UTSW |
18 |
60,353,820 (GRCm39) |
intron |
probably benign |
|
|
R9650:Iigp1c
|
UTSW |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Iigp1c
|
UTSW |
18 |
60,379,368 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Posted On |
2016-08-02 |
Incidental Mutation