Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03326:Cyp2c67'

416662

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.071) question?

Stock #

IGL03326

Quality Score

Status

Chromosome

Chromosomal Location

39608842-39649051 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 39643269 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

probably null
Transcript: ENSMUST00000067328

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam22	A	G	5: 8,127,421	S563P	probably damaging	Het
Adamtsl1	A	T	4: 86,252,748		probably benign	Het
Ampd2	T	A	3: 108,079,287	Y227F	probably benign	Het
Gk5	G	A	9: 96,137,839		probably null	Het
Gm20422	T	C	8: 69,766,698	T59A	possibly damaging	Het
Gria1	A	T	11: 57,317,773	K831N	probably damaging	Het
Hspa5	C	A	2: 34,776,117		probably benign	Het
Igtp	A	G	11: 58,206,228	D75G	probably benign	Het
Jmjd8	T	C	17: 25,829,165		probably null	Het
Kcnh2	A	T	5: 24,326,413	F158Y	probably damaging	Het
Kmt2a	A	T	9: 44,818,747	C456*	probably null	Het
Krtap5-2	A	T	7: 142,175,363	C193*	probably null	Het
Mrpl2	T	C	17: 46,649,927	V249A	possibly damaging	Het
Obscn	A	T	11: 59,032,902	I6433N	probably damaging	Het
Olfr1137	A	C	2: 87,711,695	D70E	probably damaging	Het
Olfr243	T	A	7: 103,716,862	F89L	probably benign	Het
Olfr487	T	C	7: 108,211,630	I300V	probably benign	Het
Plb1	C	T	5: 32,331,327	T985I	probably benign	Het
Polr3b	T	C	10: 84,667,395	I392T	probably benign	Het
Ppp1r1c	A	T	2: 79,808,383	N107I	probably benign	Het
Ppp1r3a	C	T	6: 14,719,766	R383Q	probably damaging	Het
Ptpre	T	C	7: 135,672,817	I499T	probably damaging	Het
Rapgef2	A	G	3: 79,091,833	I544T	probably damaging	Het
Rbm20	A	T	19: 53,814,000	Q313L	possibly damaging	Het
Rnf38	A	T	4: 44,149,182	I55N	probably benign	Het
Rtel1	T	C	2: 181,355,561		probably benign	Het
Scube1	T	C	15: 83,607,416	Y959C	probably damaging	Het
Selenow	A	G	7: 15,920,126		probably benign	Het
Tbx5	T	C	5: 119,871,298	Y291H	probably damaging	Het
Tln2	A	T	9: 67,334,257	M1022K	possibly damaging	Het
Tmtc4	G	A	14: 122,945,540	R249W	probably damaging	Het
Trim34a	A	G	7: 104,261,380	Q463R	probably benign	Het
Vps35	C	A	8: 85,274,897	E431*	probably null	Het
Wdpcp	T	C	11: 21,885,048	C684R	probably benign	Het
Xirp2	G	A	2: 67,482,246	V20I	probably benign	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39643385	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39639932	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39639967	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39615721	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39649026	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39649002	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02355:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02358:Cyp2c67	APN	19	39617417	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39643405	missense	probably benign	0.34
IGL02362:Cyp2c67	APN	19	39617382	nonsense	probably null
IGL02388:Cyp2c67	APN	19	39643355	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39643675	missense	probably benign	0.27
IGL03219:Cyp2c67	APN	19	39643294	missense	possibly damaging	0.54
IGL03349:Cyp2c67	APN	19	39643684	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39639961	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39648885	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39638694	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39609178	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39643374	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39626141	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39638625	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39638591	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39648964	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39626199	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39643264	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39643590	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39617367	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39643345	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39626237	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39609097	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39638683	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39643654	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39638588	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39643744	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39615724	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39638688	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39626232	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39615650	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39615694	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39617435	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39617429	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39617410	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39643334	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39615679	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39639897	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39615694	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39617339	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39640007	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39609264	splice site	probably null
R7474:Cyp2c67	UTSW	19	39617432	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39615640	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39609225	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39640008	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39638674	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39638711	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39626161	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39609255	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39638734	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39643679	missense	possibly damaging	0.89

Posted On

2016-08-02