Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03326:Cyp2c67'

416662

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp2c67

Ensembl Gene

ENSMUSG00000062624

Gene Name

cytochrome P450, family 2, subfamily c, polypeptide 67

Synonyms

C730004C24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL03326

Quality Score

Status

Chromosome

Chromosomal Location

39597288-39637497 bp(-) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

A to T at 39631713 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000065796 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067328]

AlphaFold

Q569X9

Predicted Effect

probably null
Transcript: ENSMUST00000067328

SMART Domains

Protein: ENSMUSP00000065796
Gene: ENSMUSG00000062624

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:p450	30	487	8.5e-150	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam22	A	G	5: 8,177,421 (GRCm39)	S563P	probably damaging	Het
Adamtsl1	A	T	4: 86,170,985 (GRCm39)		probably benign	Het
Ampd2	T	A	3: 107,986,603 (GRCm39)	Y227F	probably benign	Het
Gk5	G	A	9: 96,019,892 (GRCm39)		probably null	Het
Gm20422	T	C	8: 70,219,348 (GRCm39)	T59A	possibly damaging	Het
Gria1	A	T	11: 57,208,599 (GRCm39)	K831N	probably damaging	Het
Hspa5	C	A	2: 34,666,129 (GRCm39)		probably benign	Het
Igtp	A	G	11: 58,097,054 (GRCm39)	D75G	probably benign	Het
Jmjd8	T	C	17: 26,048,139 (GRCm39)		probably null	Het
Kcnh2	A	T	5: 24,531,411 (GRCm39)	F158Y	probably damaging	Het
Kmt2a	A	T	9: 44,730,044 (GRCm39)	C456*	probably null	Het
Krtap5-2	A	T	7: 141,729,100 (GRCm39)	C193*	probably null	Het
Mrpl2	T	C	17: 46,960,853 (GRCm39)	V249A	possibly damaging	Het
Obscn	A	T	11: 58,923,728 (GRCm39)	I6433N	probably damaging	Het
Or52a20	T	A	7: 103,366,069 (GRCm39)	F89L	probably benign	Het
Or5p63	T	C	7: 107,810,837 (GRCm39)	I300V	probably benign	Het
Or5w14	A	C	2: 87,542,039 (GRCm39)	D70E	probably damaging	Het
Plb1	C	T	5: 32,488,671 (GRCm39)	T985I	probably benign	Het
Polr3b	T	C	10: 84,503,259 (GRCm39)	I392T	probably benign	Het
Ppp1r1c	A	T	2: 79,638,727 (GRCm39)	N107I	probably benign	Het
Ppp1r3a	C	T	6: 14,719,765 (GRCm39)	R383Q	probably damaging	Het
Ptpre	T	C	7: 135,274,546 (GRCm39)	I499T	probably damaging	Het
Rapgef2	A	G	3: 78,999,140 (GRCm39)	I544T	probably damaging	Het
Rbm20	A	T	19: 53,802,431 (GRCm39)	Q313L	possibly damaging	Het
Rnf38	A	T	4: 44,149,182 (GRCm39)	I55N	probably benign	Het
Rtel1	T	C	2: 180,997,354 (GRCm39)		probably benign	Het
Scube1	T	C	15: 83,491,617 (GRCm39)	Y959C	probably damaging	Het
Selenow	A	G	7: 15,654,051 (GRCm39)		probably benign	Het
Tbx5	T	C	5: 120,009,363 (GRCm39)	Y291H	probably damaging	Het
Tln2	A	T	9: 67,241,539 (GRCm39)	M1022K	possibly damaging	Het
Tmtc4	G	A	14: 123,182,952 (GRCm39)	R249W	probably damaging	Het
Trim34a	A	G	7: 103,910,587 (GRCm39)	Q463R	probably benign	Het
Vps35	C	A	8: 86,001,526 (GRCm39)	E431*	probably null	Het
Wdpcp	T	C	11: 21,835,048 (GRCm39)	C684R	probably benign	Het
Xirp2	G	A	2: 67,312,590 (GRCm39)	V20I	probably benign	Het

Other mutations in Cyp2c67

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Cyp2c67	APN	19	39,631,829 (GRCm39)	missense	possibly damaging	0.95
IGL01025:Cyp2c67	APN	19	39,628,376 (GRCm39)	nonsense	probably null
IGL01363:Cyp2c67	APN	19	39,628,411 (GRCm39)	missense	probably damaging	0.99
IGL01819:Cyp2c67	APN	19	39,604,165 (GRCm39)	missense	probably damaging	0.98
IGL01902:Cyp2c67	APN	19	39,637,470 (GRCm39)	missense	probably damaging	1.00
IGL02172:Cyp2c67	APN	19	39,637,446 (GRCm39)	missense	possibly damaging	0.76
IGL02351:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02355:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02355:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02358:Cyp2c67	APN	19	39,605,861 (GRCm39)	missense	probably damaging	1.00
IGL02362:Cyp2c67	APN	19	39,605,826 (GRCm39)	nonsense	probably null
IGL02362:Cyp2c67	APN	19	39,631,849 (GRCm39)	missense	probably benign	0.34
IGL02388:Cyp2c67	APN	19	39,631,799 (GRCm39)	missense	probably benign	0.20
IGL03106:Cyp2c67	APN	19	39,632,119 (GRCm39)	missense	probably benign	0.27
IGL03219:Cyp2c67	APN	19	39,631,738 (GRCm39)	missense	possibly damaging	0.54
IGL03349:Cyp2c67	APN	19	39,632,128 (GRCm39)	missense	probably damaging	1.00
IGL03356:Cyp2c67	APN	19	39,628,405 (GRCm39)	missense	probably damaging	1.00
IGL03052:Cyp2c67	UTSW	19	39,637,329 (GRCm39)	missense	possibly damaging	0.88
R0585:Cyp2c67	UTSW	19	39,627,138 (GRCm39)	missense	possibly damaging	0.59
R0975:Cyp2c67	UTSW	19	39,597,622 (GRCm39)	missense	possibly damaging	0.49
R0976:Cyp2c67	UTSW	19	39,631,818 (GRCm39)	missense	probably damaging	1.00
R1252:Cyp2c67	UTSW	19	39,614,585 (GRCm39)	missense	possibly damaging	0.93
R1398:Cyp2c67	UTSW	19	39,627,069 (GRCm39)	missense	probably damaging	0.96
R1411:Cyp2c67	UTSW	19	39,627,035 (GRCm39)	missense	probably damaging	1.00
R1505:Cyp2c67	UTSW	19	39,637,408 (GRCm39)	missense	probably benign	0.00
R1543:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1613:Cyp2c67	UTSW	19	39,614,643 (GRCm39)	missense	probably benign	0.00
R1618:Cyp2c67	UTSW	19	39,631,708 (GRCm39)	splice site	probably benign
R1667:Cyp2c67	UTSW	19	39,632,034 (GRCm39)	critical splice donor site	probably null
R1852:Cyp2c67	UTSW	19	39,605,811 (GRCm39)	missense	probably benign	0.01
R2005:Cyp2c67	UTSW	19	39,631,789 (GRCm39)	missense	probably damaging	1.00
R2105:Cyp2c67	UTSW	19	39,614,681 (GRCm39)	missense	probably benign	0.24
R2181:Cyp2c67	UTSW	19	39,597,541 (GRCm39)	missense	possibly damaging	0.94
R3817:Cyp2c67	UTSW	19	39,627,127 (GRCm39)	missense	probably benign	0.00
R4669:Cyp2c67	UTSW	19	39,632,098 (GRCm39)	missense	probably benign	0.00
R4689:Cyp2c67	UTSW	19	39,627,032 (GRCm39)	missense	probably benign	0.00
R4756:Cyp2c67	UTSW	19	39,632,188 (GRCm39)	missense	probably benign	0.03
R4823:Cyp2c67	UTSW	19	39,604,168 (GRCm39)	missense	probably benign	0.13
R5152:Cyp2c67	UTSW	19	39,627,132 (GRCm39)	missense	probably benign	0.00
R5345:Cyp2c67	UTSW	19	39,614,676 (GRCm39)	missense	probably benign	0.01
R5580:Cyp2c67	UTSW	19	39,604,094 (GRCm39)	missense	probably damaging	0.99
R5644:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	possibly damaging	0.84
R6116:Cyp2c67	UTSW	19	39,605,879 (GRCm39)	missense	probably damaging	1.00
R6516:Cyp2c67	UTSW	19	39,605,873 (GRCm39)	missense	probably damaging	1.00
R6550:Cyp2c67	UTSW	19	39,605,854 (GRCm39)	nonsense	probably null
R6939:Cyp2c67	UTSW	19	39,631,778 (GRCm39)	missense	possibly damaging	0.68
R6995:Cyp2c67	UTSW	19	39,604,123 (GRCm39)	missense	probably damaging	0.96
R7028:Cyp2c67	UTSW	19	39,628,341 (GRCm39)	missense	possibly damaging	0.68
R7144:Cyp2c67	UTSW	19	39,604,138 (GRCm39)	missense	probably benign	0.00
R7242:Cyp2c67	UTSW	19	39,605,783 (GRCm39)	missense	probably benign	0.30
R7335:Cyp2c67	UTSW	19	39,628,451 (GRCm39)	nonsense	probably null
R7337:Cyp2c67	UTSW	19	39,597,708 (GRCm39)	splice site	probably null
R7474:Cyp2c67	UTSW	19	39,605,876 (GRCm39)	missense	probably null	0.05
R7642:Cyp2c67	UTSW	19	39,604,084 (GRCm39)	missense	probably damaging	0.97
R7870:Cyp2c67	UTSW	19	39,597,669 (GRCm39)	missense	probably damaging	1.00
R8152:Cyp2c67	UTSW	19	39,628,452 (GRCm39)	missense	probably benign	0.21
R8367:Cyp2c67	UTSW	19	39,627,118 (GRCm39)	missense	probably benign	0.01
R8717:Cyp2c67	UTSW	19	39,627,155 (GRCm39)	missense	probably benign	0.05
R8728:Cyp2c67	UTSW	19	39,614,605 (GRCm39)	missense	probably damaging	1.00
R9275:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9278:Cyp2c67	UTSW	19	39,597,699 (GRCm39)	missense	probably damaging	1.00
R9376:Cyp2c67	UTSW	19	39,627,178 (GRCm39)	missense	probably damaging	1.00
Z1177:Cyp2c67	UTSW	19	39,632,123 (GRCm39)	missense	possibly damaging	0.89

Posted On

2016-08-02