Incidental Mutation 'IGL03328:Or2t46'
ID 416711
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2t46
Ensembl Gene ENSMUSG00000060765
Gene Name olfactory receptor family 2 subfamily T member 46
Synonyms MOR275-11_p, Olfr325, GA_x6K02T2NKPP-844642-843680, MOR275-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL03328
Quality Score
Status
Chromosome 11
Chromosomal Location 58471663-58472703 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58472539 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 290 (N290D)
Ref Sequence ENSEMBL: ENSMUSP00000145386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169428] [ENSMUST00000203418]
AlphaFold Q5NCD2
Predicted Effect probably damaging
Transcript: ENSMUST00000169428
AA Change: N290D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000131257
Gene: ENSMUSG00000060765
AA Change: N290D

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.3e-46 PFAM
Pfam:7TM_GPCR_Srsx 39 290 1.4e-6 PFAM
Pfam:7tm_1 45 294 1.6e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000203418
AA Change: N290D

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000145386
Gene: ENSMUSG00000060765
AA Change: N290D

DomainStartEndE-ValueType
Pfam:7tm_4 35 130 7.6e-14 PFAM
Pfam:7TM_GPCR_Srsx 36 130 1.1e-4 PFAM
Pfam:7tm_1 45 130 2.6e-16 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A T 11: 84,211,355 (GRCm39) M1556L probably benign Het
Aicda T G 6: 122,539,396 (GRCm39) D187E probably benign Het
Arfgap3 A C 15: 83,227,282 (GRCm39) F43L probably damaging Het
AW551984 T C 9: 39,508,412 (GRCm39) E368G probably damaging Het
Bbs4 T C 9: 59,251,401 (GRCm39) E33G probably damaging Het
Bcas1 T A 2: 170,208,316 (GRCm39) K437* probably null Het
Brwd1 A T 16: 95,803,925 (GRCm39) W2082R probably damaging Het
Card6 A T 15: 5,134,927 (GRCm39) probably benign Het
Cd200r4 A G 16: 44,653,882 (GRCm39) I226M possibly damaging Het
Cep57l1 T C 10: 41,619,148 (GRCm39) E73G probably damaging Het
Chaf1a T G 17: 56,370,374 (GRCm39) F613C probably damaging Het
Clybl G T 14: 122,639,406 (GRCm39) K323N probably damaging Het
Coa7 A G 4: 108,195,479 (GRCm39) D136G probably damaging Het
Col5a2 C A 1: 45,415,306 (GRCm39) V1478L possibly damaging Het
Ctnnd2 T C 15: 30,921,993 (GRCm39) probably benign Het
Cyp4f17 T G 17: 32,739,600 (GRCm39) M174R probably damaging Het
Dnah10 A T 5: 124,831,354 (GRCm39) D794V probably benign Het
Eapp A G 12: 54,738,878 (GRCm39) S87P probably benign Het
Efnb3 A G 11: 69,448,031 (GRCm39) I137T probably damaging Het
Eif4e T A 3: 138,259,488 (GRCm39) probably benign Het
Fam83b T A 9: 76,400,324 (GRCm39) I260L probably benign Het
Fras1 A G 5: 96,929,619 (GRCm39) T4008A probably damaging Het
Fut8 A T 12: 77,412,003 (GRCm39) R118W probably damaging Het
Glt1d1 A C 5: 127,734,183 (GRCm39) D119A probably benign Het
Gm3727 T A 14: 7,261,685 (GRCm38) *206C probably null Het
Gmip G A 8: 70,264,261 (GRCm39) V174M possibly damaging Het
Gtf2ird1 A G 5: 134,417,983 (GRCm39) probably null Het
Haao C T 17: 84,154,078 (GRCm39) C23Y probably damaging Het
Hip1 A T 5: 135,453,728 (GRCm39) V400E probably damaging Het
Keg1 A G 19: 12,696,461 (GRCm39) N215S probably damaging Het
Lss T G 10: 76,376,785 (GRCm39) I334S probably damaging Het
Lyn A C 4: 3,745,327 (GRCm39) E77D probably benign Het
Myo3a A G 2: 22,468,210 (GRCm39) E1426G probably benign Het
Ncapg2 A G 12: 116,403,677 (GRCm39) E863G possibly damaging Het
Ncl T C 1: 86,280,319 (GRCm39) Y496C probably damaging Het
Nefm A T 14: 68,358,739 (GRCm39) S432T probably benign Het
Nipsnap1 A G 11: 4,834,096 (GRCm39) Y95C possibly damaging Het
Npc1l1 C A 11: 6,168,643 (GRCm39) E913* probably null Het
Nup205 T C 6: 35,209,349 (GRCm39) L1552P probably damaging Het
Or4c112 G T 2: 88,854,199 (GRCm39) Y49* probably null Het
Or52h7 T A 7: 104,213,677 (GRCm39) V83D probably damaging Het
Or7c70 C T 10: 78,683,201 (GRCm39) E183K probably benign Het
Osm A C 11: 4,188,426 (GRCm39) I18L unknown Het
Otoa T A 7: 120,710,217 (GRCm39) S254R probably damaging Het
Parp1 T C 1: 180,427,155 (GRCm39) probably benign Het
Pcdh17 A G 14: 84,770,551 (GRCm39) I1010V probably benign Het
Peli2 A T 14: 48,490,032 (GRCm39) probably null Het
Pkd1l3 T G 8: 110,388,738 (GRCm39) probably benign Het
Pkhd1 A G 1: 20,151,524 (GRCm39) probably benign Het
Polg2 A C 11: 106,659,163 (GRCm39) V450G probably benign Het
Potegl A T 2: 23,102,817 (GRCm39) Y185F possibly damaging Het
Ptpn13 A T 5: 103,664,214 (GRCm39) T401S probably benign Het
Rgs22 C T 15: 36,043,350 (GRCm39) probably null Het
Rttn T G 18: 89,061,152 (GRCm39) S1107A probably benign Het
Scn5a G T 9: 119,366,702 (GRCm39) N328K probably benign Het
Sned1 G A 1: 93,217,089 (GRCm39) A1325T probably benign Het
St8sia4 T A 1: 95,588,595 (GRCm39) E80V probably benign Het
Stard7 T C 2: 127,134,176 (GRCm39) probably benign Het
Suco G T 1: 161,647,990 (GRCm39) P1099T probably damaging Het
Syn2 G T 6: 115,251,221 (GRCm39) C459F probably damaging Het
Tas2r117 A C 6: 132,780,041 (GRCm39) I60L probably benign Het
Tomm70a T C 16: 56,965,150 (GRCm39) C445R probably damaging Het
Tpsab1 T A 17: 25,564,102 (GRCm39) D87V probably benign Het
Trgc4 A G 13: 19,536,416 (GRCm39) Y158C unknown Het
Trpm6 A T 19: 18,815,446 (GRCm39) E1177D possibly damaging Het
Vmn2r71 A T 7: 85,273,499 (GRCm39) D771V probably damaging Het
Vmn2r93 A T 17: 18,525,220 (GRCm39) T293S probably damaging Het
Other mutations in Or2t46
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Or2t46 APN 11 58,472,636 (GRCm39) missense probably benign
IGL01922:Or2t46 APN 11 58,471,899 (GRCm39) missense probably benign 0.01
IGL02440:Or2t46 APN 11 58,472,035 (GRCm39) missense probably damaging 1.00
IGL02456:Or2t46 APN 11 58,472,024 (GRCm39) missense possibly damaging 0.48
IGL03088:Or2t46 APN 11 58,472,653 (GRCm39) utr 3 prime probably benign
R0604:Or2t46 UTSW 11 58,472,174 (GRCm39) missense probably damaging 0.99
R1698:Or2t46 UTSW 11 58,472,077 (GRCm39) missense probably damaging 1.00
R2473:Or2t46 UTSW 11 58,472,401 (GRCm39) missense probably damaging 1.00
R2888:Or2t46 UTSW 11 58,471,988 (GRCm39) missense possibly damaging 0.96
R4133:Or2t46 UTSW 11 58,471,901 (GRCm39) missense probably damaging 0.97
R4710:Or2t46 UTSW 11 58,472,548 (GRCm39) missense probably damaging 1.00
R4715:Or2t46 UTSW 11 58,472,255 (GRCm39) missense probably damaging 1.00
R4898:Or2t46 UTSW 11 58,472,546 (GRCm39) missense probably damaging 1.00
R4939:Or2t46 UTSW 11 58,472,037 (GRCm39) missense probably damaging 1.00
R4977:Or2t46 UTSW 11 58,472,455 (GRCm39) missense possibly damaging 0.57
R5389:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R5393:Or2t46 UTSW 11 58,471,825 (GRCm39) missense possibly damaging 0.78
R6137:Or2t46 UTSW 11 58,471,894 (GRCm39) missense probably benign
R6302:Or2t46 UTSW 11 58,472,464 (GRCm39) missense probably benign
R6655:Or2t46 UTSW 11 58,472,036 (GRCm39) missense probably damaging 1.00
R6927:Or2t46 UTSW 11 58,472,491 (GRCm39) missense possibly damaging 0.81
R7451:Or2t46 UTSW 11 58,472,516 (GRCm39) missense probably damaging 1.00
R7494:Or2t46 UTSW 11 58,472,038 (GRCm39) missense probably damaging 0.97
R7626:Or2t46 UTSW 11 58,471,999 (GRCm39) missense probably damaging 0.97
R7724:Or2t46 UTSW 11 58,472,208 (GRCm39) missense probably benign 0.01
R7874:Or2t46 UTSW 11 58,472,573 (GRCm39) missense possibly damaging 0.93
R8217:Or2t46 UTSW 11 58,471,792 (GRCm39) missense probably benign 0.00
R8252:Or2t46 UTSW 11 58,471,958 (GRCm39) missense probably damaging 1.00
R8992:Or2t46 UTSW 11 58,471,738 (GRCm39) missense probably benign 0.00
R9376:Or2t46 UTSW 11 58,472,636 (GRCm39) missense probably benign
R9439:Or2t46 UTSW 11 58,472,104 (GRCm39) missense probably benign 0.38
Z1177:Or2t46 UTSW 11 58,472,137 (GRCm39) missense probably damaging 1.00
Z1186:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1186:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1186:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1187:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1187:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1188:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1188:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1189:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1189:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1190:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1190:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,828 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1191:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Z1191:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,472,122 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,757 (GRCm39) missense probably benign
Z1192:Or2t46 UTSW 11 58,471,750 (GRCm39) missense probably benign 0.00
Z1192:Or2t46 UTSW 11 58,472,483 (GRCm39) missense probably benign
Posted On 2016-08-02