Incidental Mutation 'IGL03328:Brwd1'
| ID |
416722 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Brwd1
|
| Ensembl Gene |
ENSMUSG00000022914 |
| Gene Name |
bromodomain and WD repeat domain containing 1 |
| Synonyms |
5330419I02Rik, Wdr9, G1-403-16, D530019K20Rik, repro5 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03328
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
95793292-95883726 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 95803925 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 2082
(W2082R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109460
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023631]
[ENSMUST00000099502]
[ENSMUST00000113829]
[ENSMUST00000153398]
|
| AlphaFold |
Q921C3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023631
AA Change: W2082R
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000023631
Gene: ENSMUSG00000022914
AA Change: W2082R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099502
AA Change: W2082R
PolyPhen 2
Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000097101
Gene: ENSMUSG00000022914
AA Change: W2082R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.42e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2260 |
2270 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113829
AA Change: W2082R
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000109460
Gene: ENSMUSG00000022914
AA Change: W2082R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
low complexity region
|
1497 |
1513 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1558 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1574 |
1762 |
1.13e-9 |
PROSPERO |
|
low complexity region
|
1764 |
1775 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1857 |
2050 |
1.13e-9 |
PROSPERO |
|
low complexity region
|
2165 |
2174 |
N/A |
INTRINSIC |
|
low complexity region
|
2177 |
2188 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000153398
AA Change: W2547R
|
| SMART Domains |
Protein: ENSMUSP00000117066
Gene: ENSMUSG00000022914
AA Change: W2547R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
36 |
48 |
N/A |
INTRINSIC |
|
WD40
|
175 |
214 |
1.3e-7 |
SMART |
|
WD40
|
217 |
256 |
2.26e-7 |
SMART |
|
WD40
|
259 |
302 |
1.83e-7 |
SMART |
|
WD40
|
311 |
352 |
3.82e1 |
SMART |
|
WD40
|
357 |
396 |
4.27e-8 |
SMART |
|
WD40
|
417 |
454 |
8.59e-1 |
SMART |
|
WD40
|
457 |
497 |
1.47e-6 |
SMART |
|
WD40
|
504 |
544 |
9.21e0 |
SMART |
|
low complexity region
|
660 |
676 |
N/A |
INTRINSIC |
|
low complexity region
|
753 |
767 |
N/A |
INTRINSIC |
|
low complexity region
|
852 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
906 |
927 |
N/A |
INTRINSIC |
|
BROMO
|
1156 |
1267 |
1.72e-6 |
SMART |
|
low complexity region
|
1277 |
1292 |
N/A |
INTRINSIC |
|
BROMO
|
1317 |
1422 |
2.65e-30 |
SMART |
|
internal_repeat_1
|
1491 |
1957 |
1.45e-251 |
PROSPERO |
|
internal_repeat_1
|
1956 |
2422 |
1.45e-251 |
PROSPERO |
|
low complexity region
|
2630 |
2639 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156622
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000157037
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous males and females are infertile. Spermiogenesis is impaired; males have low epididymal sperm concentration with low motility and abnormal sperm head morphology. Female oocytes commonly contain vacuoles and have low developmental competence to 2-cell and blastocyst stages. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
A |
T |
11: 84,211,355 (GRCm39) |
M1556L |
probably benign |
Het |
| Aicda |
T |
G |
6: 122,539,396 (GRCm39) |
D187E |
probably benign |
Het |
| Arfgap3 |
A |
C |
15: 83,227,282 (GRCm39) |
F43L |
probably damaging |
Het |
| AW551984 |
T |
C |
9: 39,508,412 (GRCm39) |
E368G |
probably damaging |
Het |
| Bbs4 |
T |
C |
9: 59,251,401 (GRCm39) |
E33G |
probably damaging |
Het |
| Bcas1 |
T |
A |
2: 170,208,316 (GRCm39) |
K437* |
probably null |
Het |
| Card6 |
A |
T |
15: 5,134,927 (GRCm39) |
|
probably benign |
Het |
| Cd200r4 |
A |
G |
16: 44,653,882 (GRCm39) |
I226M |
possibly damaging |
Het |
| Cep57l1 |
T |
C |
10: 41,619,148 (GRCm39) |
E73G |
probably damaging |
Het |
| Chaf1a |
T |
G |
17: 56,370,374 (GRCm39) |
F613C |
probably damaging |
Het |
| Clybl |
G |
T |
14: 122,639,406 (GRCm39) |
K323N |
probably damaging |
Het |
| Coa7 |
A |
G |
4: 108,195,479 (GRCm39) |
D136G |
probably damaging |
Het |
| Col5a2 |
C |
A |
1: 45,415,306 (GRCm39) |
V1478L |
possibly damaging |
Het |
| Ctnnd2 |
T |
C |
15: 30,921,993 (GRCm39) |
|
probably benign |
Het |
| Cyp4f17 |
T |
G |
17: 32,739,600 (GRCm39) |
M174R |
probably damaging |
Het |
| Dnah10 |
A |
T |
5: 124,831,354 (GRCm39) |
D794V |
probably benign |
Het |
| Eapp |
A |
G |
12: 54,738,878 (GRCm39) |
S87P |
probably benign |
Het |
| Efnb3 |
A |
G |
11: 69,448,031 (GRCm39) |
I137T |
probably damaging |
Het |
| Eif4e |
T |
A |
3: 138,259,488 (GRCm39) |
|
probably benign |
Het |
| Fam83b |
T |
A |
9: 76,400,324 (GRCm39) |
I260L |
probably benign |
Het |
| Fras1 |
A |
G |
5: 96,929,619 (GRCm39) |
T4008A |
probably damaging |
Het |
| Fut8 |
A |
T |
12: 77,412,003 (GRCm39) |
R118W |
probably damaging |
Het |
| Glt1d1 |
A |
C |
5: 127,734,183 (GRCm39) |
D119A |
probably benign |
Het |
| Gm3727 |
T |
A |
14: 7,261,685 (GRCm38) |
*206C |
probably null |
Het |
| Gmip |
G |
A |
8: 70,264,261 (GRCm39) |
V174M |
possibly damaging |
Het |
| Gtf2ird1 |
A |
G |
5: 134,417,983 (GRCm39) |
|
probably null |
Het |
| Haao |
C |
T |
17: 84,154,078 (GRCm39) |
C23Y |
probably damaging |
Het |
| Hip1 |
A |
T |
5: 135,453,728 (GRCm39) |
V400E |
probably damaging |
Het |
| Keg1 |
A |
G |
19: 12,696,461 (GRCm39) |
N215S |
probably damaging |
Het |
| Lss |
T |
G |
10: 76,376,785 (GRCm39) |
I334S |
probably damaging |
Het |
| Lyn |
A |
C |
4: 3,745,327 (GRCm39) |
E77D |
probably benign |
Het |
| Myo3a |
A |
G |
2: 22,468,210 (GRCm39) |
E1426G |
probably benign |
Het |
| Ncapg2 |
A |
G |
12: 116,403,677 (GRCm39) |
E863G |
possibly damaging |
Het |
| Ncl |
T |
C |
1: 86,280,319 (GRCm39) |
Y496C |
probably damaging |
Het |
| Nefm |
A |
T |
14: 68,358,739 (GRCm39) |
S432T |
probably benign |
Het |
| Nipsnap1 |
A |
G |
11: 4,834,096 (GRCm39) |
Y95C |
possibly damaging |
Het |
| Npc1l1 |
C |
A |
11: 6,168,643 (GRCm39) |
E913* |
probably null |
Het |
| Nup205 |
T |
C |
6: 35,209,349 (GRCm39) |
L1552P |
probably damaging |
Het |
| Or2t46 |
A |
G |
11: 58,472,539 (GRCm39) |
N290D |
probably damaging |
Het |
| Or4c112 |
G |
T |
2: 88,854,199 (GRCm39) |
Y49* |
probably null |
Het |
| Or52h7 |
T |
A |
7: 104,213,677 (GRCm39) |
V83D |
probably damaging |
Het |
| Or7c70 |
C |
T |
10: 78,683,201 (GRCm39) |
E183K |
probably benign |
Het |
| Osm |
A |
C |
11: 4,188,426 (GRCm39) |
I18L |
unknown |
Het |
| Otoa |
T |
A |
7: 120,710,217 (GRCm39) |
S254R |
probably damaging |
Het |
| Parp1 |
T |
C |
1: 180,427,155 (GRCm39) |
|
probably benign |
Het |
| Pcdh17 |
A |
G |
14: 84,770,551 (GRCm39) |
I1010V |
probably benign |
Het |
| Peli2 |
A |
T |
14: 48,490,032 (GRCm39) |
|
probably null |
Het |
| Pkd1l3 |
T |
G |
8: 110,388,738 (GRCm39) |
|
probably benign |
Het |
| Pkhd1 |
A |
G |
1: 20,151,524 (GRCm39) |
|
probably benign |
Het |
| Polg2 |
A |
C |
11: 106,659,163 (GRCm39) |
V450G |
probably benign |
Het |
| Potegl |
A |
T |
2: 23,102,817 (GRCm39) |
Y185F |
possibly damaging |
Het |
| Ptpn13 |
A |
T |
5: 103,664,214 (GRCm39) |
T401S |
probably benign |
Het |
| Rgs22 |
C |
T |
15: 36,043,350 (GRCm39) |
|
probably null |
Het |
| Rttn |
T |
G |
18: 89,061,152 (GRCm39) |
S1107A |
probably benign |
Het |
| Scn5a |
G |
T |
9: 119,366,702 (GRCm39) |
N328K |
probably benign |
Het |
| Sned1 |
G |
A |
1: 93,217,089 (GRCm39) |
A1325T |
probably benign |
Het |
| St8sia4 |
T |
A |
1: 95,588,595 (GRCm39) |
E80V |
probably benign |
Het |
| Stard7 |
T |
C |
2: 127,134,176 (GRCm39) |
|
probably benign |
Het |
| Suco |
G |
T |
1: 161,647,990 (GRCm39) |
P1099T |
probably damaging |
Het |
| Syn2 |
G |
T |
6: 115,251,221 (GRCm39) |
C459F |
probably damaging |
Het |
| Tas2r117 |
A |
C |
6: 132,780,041 (GRCm39) |
I60L |
probably benign |
Het |
| Tomm70a |
T |
C |
16: 56,965,150 (GRCm39) |
C445R |
probably damaging |
Het |
| Tpsab1 |
T |
A |
17: 25,564,102 (GRCm39) |
D87V |
probably benign |
Het |
| Trgc4 |
A |
G |
13: 19,536,416 (GRCm39) |
Y158C |
unknown |
Het |
| Trpm6 |
A |
T |
19: 18,815,446 (GRCm39) |
E1177D |
possibly damaging |
Het |
| Vmn2r71 |
A |
T |
7: 85,273,499 (GRCm39) |
D771V |
probably damaging |
Het |
| Vmn2r93 |
A |
T |
17: 18,525,220 (GRCm39) |
T293S |
probably damaging |
Het |
|
| Other mutations in Brwd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00690:Brwd1
|
APN |
16 |
95,818,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Brwd1
|
APN |
16 |
95,844,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Brwd1
|
APN |
16 |
95,817,373 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01447:Brwd1
|
APN |
16 |
95,848,579 (GRCm39) |
nonsense |
probably null |
|
|
IGL01459:Brwd1
|
APN |
16 |
95,848,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01631:Brwd1
|
APN |
16 |
95,847,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Brwd1
|
APN |
16 |
95,815,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02264:Brwd1
|
APN |
16 |
95,820,656 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02679:Brwd1
|
APN |
16 |
95,804,023 (GRCm39) |
missense |
probably benign |
|
|
IGL02833:Brwd1
|
APN |
16 |
95,853,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Brwd1
|
APN |
16 |
95,858,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03053:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03074:Brwd1
|
APN |
16 |
95,813,050 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03135:Brwd1
|
APN |
16 |
95,822,458 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03168:Brwd1
|
APN |
16 |
95,818,877 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL03214:Brwd1
|
APN |
16 |
95,839,100 (GRCm39) |
missense |
probably benign |
0.26 |
|
bromide
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Embers
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Glowing
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Soporific
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
G1citation:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4243001:Brwd1
|
UTSW |
16 |
95,803,871 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0012:Brwd1
|
UTSW |
16 |
95,860,852 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0030:Brwd1
|
UTSW |
16 |
95,822,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0135:Brwd1
|
UTSW |
16 |
95,848,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Brwd1
|
UTSW |
16 |
95,839,164 (GRCm39) |
nonsense |
probably null |
|
|
R0551:Brwd1
|
UTSW |
16 |
95,837,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0586:Brwd1
|
UTSW |
16 |
95,844,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0865:Brwd1
|
UTSW |
16 |
95,869,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1226:Brwd1
|
UTSW |
16 |
95,832,748 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1329:Brwd1
|
UTSW |
16 |
95,804,434 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1378:Brwd1
|
UTSW |
16 |
95,842,570 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1420:Brwd1
|
UTSW |
16 |
95,837,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1441:Brwd1
|
UTSW |
16 |
95,867,351 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1484:Brwd1
|
UTSW |
16 |
95,829,491 (GRCm39) |
splice site |
probably null |
|
|
R1624:Brwd1
|
UTSW |
16 |
95,809,344 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1636:Brwd1
|
UTSW |
16 |
95,860,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Brwd1
|
UTSW |
16 |
95,822,437 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1998:Brwd1
|
UTSW |
16 |
95,822,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2066:Brwd1
|
UTSW |
16 |
95,847,665 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2898:Brwd1
|
UTSW |
16 |
95,867,300 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2983:Brwd1
|
UTSW |
16 |
95,867,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3966:Brwd1
|
UTSW |
16 |
95,845,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4086:Brwd1
|
UTSW |
16 |
95,847,572 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4257:Brwd1
|
UTSW |
16 |
95,824,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4290:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4292:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4293:Brwd1
|
UTSW |
16 |
95,818,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4614:Brwd1
|
UTSW |
16 |
95,848,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Brwd1
|
UTSW |
16 |
95,804,518 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5025:Brwd1
|
UTSW |
16 |
95,855,172 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5155:Brwd1
|
UTSW |
16 |
95,803,993 (GRCm39) |
nonsense |
probably null |
|
|
R5229:Brwd1
|
UTSW |
16 |
95,803,409 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5246:Brwd1
|
UTSW |
16 |
95,803,757 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5668:Brwd1
|
UTSW |
16 |
95,817,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5763:Brwd1
|
UTSW |
16 |
95,835,043 (GRCm39) |
nonsense |
probably null |
|
|
R5782:Brwd1
|
UTSW |
16 |
95,844,243 (GRCm39) |
nonsense |
probably null |
|
|
R5831:Brwd1
|
UTSW |
16 |
95,820,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5836:Brwd1
|
UTSW |
16 |
95,865,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5995:Brwd1
|
UTSW |
16 |
95,865,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Brwd1
|
UTSW |
16 |
95,804,156 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6241:Brwd1
|
UTSW |
16 |
95,815,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Brwd1
|
UTSW |
16 |
95,809,141 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6362:Brwd1
|
UTSW |
16 |
95,803,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6551:Brwd1
|
UTSW |
16 |
95,795,162 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6736:Brwd1
|
UTSW |
16 |
95,869,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6822:Brwd1
|
UTSW |
16 |
95,842,474 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7080:Brwd1
|
UTSW |
16 |
95,810,730 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7131:Brwd1
|
UTSW |
16 |
95,867,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7208:Brwd1
|
UTSW |
16 |
95,837,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7322:Brwd1
|
UTSW |
16 |
95,867,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Brwd1
|
UTSW |
16 |
95,857,373 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7615:Brwd1
|
UTSW |
16 |
95,835,039 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7621:Brwd1
|
UTSW |
16 |
95,866,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7665:Brwd1
|
UTSW |
16 |
95,842,543 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7697:Brwd1
|
UTSW |
16 |
95,847,601 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7740:Brwd1
|
UTSW |
16 |
95,828,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8120:Brwd1
|
UTSW |
16 |
95,820,649 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8187:Brwd1
|
UTSW |
16 |
95,803,934 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8359:Brwd1
|
UTSW |
16 |
95,817,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8480:Brwd1
|
UTSW |
16 |
95,848,630 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8511:Brwd1
|
UTSW |
16 |
95,859,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9046:Brwd1
|
UTSW |
16 |
95,829,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9074:Brwd1
|
UTSW |
16 |
95,824,610 (GRCm39) |
missense |
|
|
|
R9102:Brwd1
|
UTSW |
16 |
95,869,725 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9115:Brwd1
|
UTSW |
16 |
95,848,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9130:Brwd1
|
UTSW |
16 |
95,866,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9200:Brwd1
|
UTSW |
16 |
95,839,154 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9246:Brwd1
|
UTSW |
16 |
95,804,016 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9407:Brwd1
|
UTSW |
16 |
95,803,693 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9444:Brwd1
|
UTSW |
16 |
95,855,180 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9451:Brwd1
|
UTSW |
16 |
95,845,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Brwd1
|
UTSW |
16 |
95,813,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9751:Brwd1
|
UTSW |
16 |
95,795,015 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9753:Brwd1
|
UTSW |
16 |
95,825,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0017:Brwd1
|
UTSW |
16 |
95,845,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0028:Brwd1
|
UTSW |
16 |
95,813,123 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
| Posted On |
2016-08-02 |
Incidental Mutation