Incidental Mutation 'IGL03328:Ncapg2'
ID 416727
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ncapg2
Ensembl Gene ENSMUSG00000042029
Gene Name non-SMC condensin II complex, subunit G2
Synonyms 5830426I05Rik, Mtb, mCAP-G2, Luzp5
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03328
Quality Score
Status
Chromosome 12
Chromosomal Location 116368969-116427152 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116403677 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 863 (E863G)
Ref Sequence ENSEMBL: ENSMUSP00000081889 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084828]
AlphaFold Q6DFV1
Predicted Effect possibly damaging
Transcript: ENSMUST00000084828
AA Change: E863G

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000081889
Gene: ENSMUSG00000042029
AA Change: E863G

DomainStartEndE-ValueType
low complexity region 14 25 N/A INTRINSIC
Pfam:Condensin2nSMC 212 361 7.2e-62 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
PHENOTYPE: Homozygous null embryos exhibit impaired inner cell mass expansion and die shortly after implantation and prior to gastrulation and blood cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A T 11: 84,211,355 (GRCm39) M1556L probably benign Het
Aicda T G 6: 122,539,396 (GRCm39) D187E probably benign Het
Arfgap3 A C 15: 83,227,282 (GRCm39) F43L probably damaging Het
AW551984 T C 9: 39,508,412 (GRCm39) E368G probably damaging Het
Bbs4 T C 9: 59,251,401 (GRCm39) E33G probably damaging Het
Bcas1 T A 2: 170,208,316 (GRCm39) K437* probably null Het
Brwd1 A T 16: 95,803,925 (GRCm39) W2082R probably damaging Het
Card6 A T 15: 5,134,927 (GRCm39) probably benign Het
Cd200r4 A G 16: 44,653,882 (GRCm39) I226M possibly damaging Het
Cep57l1 T C 10: 41,619,148 (GRCm39) E73G probably damaging Het
Chaf1a T G 17: 56,370,374 (GRCm39) F613C probably damaging Het
Clybl G T 14: 122,639,406 (GRCm39) K323N probably damaging Het
Coa7 A G 4: 108,195,479 (GRCm39) D136G probably damaging Het
Col5a2 C A 1: 45,415,306 (GRCm39) V1478L possibly damaging Het
Ctnnd2 T C 15: 30,921,993 (GRCm39) probably benign Het
Cyp4f17 T G 17: 32,739,600 (GRCm39) M174R probably damaging Het
Dnah10 A T 5: 124,831,354 (GRCm39) D794V probably benign Het
Eapp A G 12: 54,738,878 (GRCm39) S87P probably benign Het
Efnb3 A G 11: 69,448,031 (GRCm39) I137T probably damaging Het
Eif4e T A 3: 138,259,488 (GRCm39) probably benign Het
Fam83b T A 9: 76,400,324 (GRCm39) I260L probably benign Het
Fras1 A G 5: 96,929,619 (GRCm39) T4008A probably damaging Het
Fut8 A T 12: 77,412,003 (GRCm39) R118W probably damaging Het
Glt1d1 A C 5: 127,734,183 (GRCm39) D119A probably benign Het
Gm3727 T A 14: 7,261,685 (GRCm38) *206C probably null Het
Gmip G A 8: 70,264,261 (GRCm39) V174M possibly damaging Het
Gtf2ird1 A G 5: 134,417,983 (GRCm39) probably null Het
Haao C T 17: 84,154,078 (GRCm39) C23Y probably damaging Het
Hip1 A T 5: 135,453,728 (GRCm39) V400E probably damaging Het
Keg1 A G 19: 12,696,461 (GRCm39) N215S probably damaging Het
Lss T G 10: 76,376,785 (GRCm39) I334S probably damaging Het
Lyn A C 4: 3,745,327 (GRCm39) E77D probably benign Het
Myo3a A G 2: 22,468,210 (GRCm39) E1426G probably benign Het
Ncl T C 1: 86,280,319 (GRCm39) Y496C probably damaging Het
Nefm A T 14: 68,358,739 (GRCm39) S432T probably benign Het
Nipsnap1 A G 11: 4,834,096 (GRCm39) Y95C possibly damaging Het
Npc1l1 C A 11: 6,168,643 (GRCm39) E913* probably null Het
Nup205 T C 6: 35,209,349 (GRCm39) L1552P probably damaging Het
Or2t46 A G 11: 58,472,539 (GRCm39) N290D probably damaging Het
Or4c112 G T 2: 88,854,199 (GRCm39) Y49* probably null Het
Or52h7 T A 7: 104,213,677 (GRCm39) V83D probably damaging Het
Or7c70 C T 10: 78,683,201 (GRCm39) E183K probably benign Het
Osm A C 11: 4,188,426 (GRCm39) I18L unknown Het
Otoa T A 7: 120,710,217 (GRCm39) S254R probably damaging Het
Parp1 T C 1: 180,427,155 (GRCm39) probably benign Het
Pcdh17 A G 14: 84,770,551 (GRCm39) I1010V probably benign Het
Peli2 A T 14: 48,490,032 (GRCm39) probably null Het
Pkd1l3 T G 8: 110,388,738 (GRCm39) probably benign Het
Pkhd1 A G 1: 20,151,524 (GRCm39) probably benign Het
Polg2 A C 11: 106,659,163 (GRCm39) V450G probably benign Het
Potegl A T 2: 23,102,817 (GRCm39) Y185F possibly damaging Het
Ptpn13 A T 5: 103,664,214 (GRCm39) T401S probably benign Het
Rgs22 C T 15: 36,043,350 (GRCm39) probably null Het
Rttn T G 18: 89,061,152 (GRCm39) S1107A probably benign Het
Scn5a G T 9: 119,366,702 (GRCm39) N328K probably benign Het
Sned1 G A 1: 93,217,089 (GRCm39) A1325T probably benign Het
St8sia4 T A 1: 95,588,595 (GRCm39) E80V probably benign Het
Stard7 T C 2: 127,134,176 (GRCm39) probably benign Het
Suco G T 1: 161,647,990 (GRCm39) P1099T probably damaging Het
Syn2 G T 6: 115,251,221 (GRCm39) C459F probably damaging Het
Tas2r117 A C 6: 132,780,041 (GRCm39) I60L probably benign Het
Tomm70a T C 16: 56,965,150 (GRCm39) C445R probably damaging Het
Tpsab1 T A 17: 25,564,102 (GRCm39) D87V probably benign Het
Trgc4 A G 13: 19,536,416 (GRCm39) Y158C unknown Het
Trpm6 A T 19: 18,815,446 (GRCm39) E1177D possibly damaging Het
Vmn2r71 A T 7: 85,273,499 (GRCm39) D771V probably damaging Het
Vmn2r93 A T 17: 18,525,220 (GRCm39) T293S probably damaging Het
Other mutations in Ncapg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Ncapg2 APN 12 116,388,270 (GRCm39) missense possibly damaging 0.54
IGL01694:Ncapg2 APN 12 116,370,850 (GRCm39) utr 5 prime probably benign
IGL01724:Ncapg2 APN 12 116,390,331 (GRCm39) missense probably damaging 1.00
IGL01792:Ncapg2 APN 12 116,389,438 (GRCm39) missense probably damaging 0.99
IGL02098:Ncapg2 APN 12 116,407,952 (GRCm39) missense possibly damaging 0.59
IGL02136:Ncapg2 APN 12 116,424,203 (GRCm39) missense probably benign
IGL02409:Ncapg2 APN 12 116,384,337 (GRCm39) missense probably damaging 1.00
IGL02580:Ncapg2 APN 12 116,384,309 (GRCm39) missense probably damaging 1.00
IGL02653:Ncapg2 APN 12 116,389,526 (GRCm39) critical splice donor site probably null
IGL03073:Ncapg2 APN 12 116,415,894 (GRCm39) missense probably benign 0.01
IGL03114:Ncapg2 APN 12 116,415,993 (GRCm39) splice site probably benign
IGL03199:Ncapg2 APN 12 116,382,856 (GRCm39) missense probably damaging 1.00
P0033:Ncapg2 UTSW 12 116,402,255 (GRCm39) missense probably benign 0.03
R0008:Ncapg2 UTSW 12 116,393,455 (GRCm39) missense probably damaging 1.00
R0194:Ncapg2 UTSW 12 116,384,303 (GRCm39) splice site probably null
R0379:Ncapg2 UTSW 12 116,406,695 (GRCm39) missense probably damaging 1.00
R0568:Ncapg2 UTSW 12 116,386,835 (GRCm39) missense probably damaging 1.00
R0771:Ncapg2 UTSW 12 116,376,779 (GRCm39) nonsense probably null
R1016:Ncapg2 UTSW 12 116,402,295 (GRCm39) missense probably damaging 1.00
R1507:Ncapg2 UTSW 12 116,424,186 (GRCm39) missense probably benign 0.00
R1524:Ncapg2 UTSW 12 116,398,198 (GRCm39) splice site probably benign
R1596:Ncapg2 UTSW 12 116,382,856 (GRCm39) missense probably damaging 1.00
R1635:Ncapg2 UTSW 12 116,398,305 (GRCm39) frame shift probably null
R1752:Ncapg2 UTSW 12 116,390,338 (GRCm39) missense probably damaging 1.00
R2164:Ncapg2 UTSW 12 116,414,095 (GRCm39) splice site probably null
R2266:Ncapg2 UTSW 12 116,393,296 (GRCm39) missense probably damaging 1.00
R2366:Ncapg2 UTSW 12 116,384,349 (GRCm39) nonsense probably null
R2924:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R2925:Ncapg2 UTSW 12 116,402,349 (GRCm39) missense probably benign 0.03
R3828:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R3829:Ncapg2 UTSW 12 116,370,938 (GRCm39) splice site probably benign
R4384:Ncapg2 UTSW 12 116,403,497 (GRCm39) critical splice donor site probably null
R4651:Ncapg2 UTSW 12 116,389,407 (GRCm39) missense probably damaging 1.00
R4701:Ncapg2 UTSW 12 116,404,238 (GRCm39) missense probably benign
R4821:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R4845:Ncapg2 UTSW 12 116,404,208 (GRCm39) missense probably damaging 0.96
R5135:Ncapg2 UTSW 12 116,391,406 (GRCm39) missense possibly damaging 0.64
R5294:Ncapg2 UTSW 12 116,391,414 (GRCm39) missense possibly damaging 0.54
R5334:Ncapg2 UTSW 12 116,390,257 (GRCm39) missense probably damaging 1.00
R5588:Ncapg2 UTSW 12 116,376,697 (GRCm39) missense possibly damaging 0.95
R5888:Ncapg2 UTSW 12 116,389,420 (GRCm39) missense possibly damaging 0.84
R5938:Ncapg2 UTSW 12 116,393,277 (GRCm39) missense probably damaging 1.00
R5978:Ncapg2 UTSW 12 116,388,291 (GRCm39) missense possibly damaging 0.68
R6016:Ncapg2 UTSW 12 116,390,227 (GRCm39) missense probably damaging 1.00
R6026:Ncapg2 UTSW 12 116,406,641 (GRCm39) missense possibly damaging 0.73
R6155:Ncapg2 UTSW 12 116,401,631 (GRCm39) missense possibly damaging 0.83
R6509:Ncapg2 UTSW 12 116,391,376 (GRCm39) missense probably damaging 1.00
R6675:Ncapg2 UTSW 12 116,398,281 (GRCm39) missense possibly damaging 0.71
R6912:Ncapg2 UTSW 12 116,390,202 (GRCm39) missense probably benign
R7069:Ncapg2 UTSW 12 116,388,337 (GRCm39) splice site probably null
R7339:Ncapg2 UTSW 12 116,378,454 (GRCm39) missense probably damaging 0.96
R7440:Ncapg2 UTSW 12 116,414,033 (GRCm39) missense possibly damaging 0.89
R7445:Ncapg2 UTSW 12 116,382,888 (GRCm39) missense possibly damaging 0.50
R7704:Ncapg2 UTSW 12 116,382,897 (GRCm39) missense probably damaging 1.00
R8061:Ncapg2 UTSW 12 116,390,197 (GRCm39) missense probably benign
R8132:Ncapg2 UTSW 12 116,407,967 (GRCm39) missense possibly damaging 0.93
R8166:Ncapg2 UTSW 12 116,376,036 (GRCm39) missense probably benign 0.00
R8351:Ncapg2 UTSW 12 116,403,647 (GRCm39) missense possibly damaging 0.80
R8526:Ncapg2 UTSW 12 116,403,679 (GRCm39) missense probably benign 0.00
R8692:Ncapg2 UTSW 12 116,414,049 (GRCm39) missense probably damaging 1.00
R8739:Ncapg2 UTSW 12 116,379,098 (GRCm39) missense possibly damaging 0.75
R8766:Ncapg2 UTSW 12 116,390,356 (GRCm39) missense probably damaging 1.00
R8929:Ncapg2 UTSW 12 116,415,983 (GRCm39) missense probably damaging 1.00
R9046:Ncapg2 UTSW 12 116,376,145 (GRCm39) missense probably benign 0.01
R9187:Ncapg2 UTSW 12 116,402,287 (GRCm39) missense probably damaging 1.00
R9344:Ncapg2 UTSW 12 116,388,273 (GRCm39) missense probably damaging 1.00
R9444:Ncapg2 UTSW 12 116,370,863 (GRCm39) missense probably damaging 1.00
R9580:Ncapg2 UTSW 12 116,424,228 (GRCm39) missense probably damaging 1.00
R9634:Ncapg2 UTSW 12 116,379,077 (GRCm39) missense probably damaging 0.99
R9749:Ncapg2 UTSW 12 116,411,368 (GRCm39) nonsense probably null
X0020:Ncapg2 UTSW 12 116,388,327 (GRCm39) missense probably damaging 1.00
Z1177:Ncapg2 UTSW 12 116,402,225 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02