Incidental Mutation 'IGL03328:Rgs22'
ID 416767
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rgs22
Ensembl Gene ENSMUSG00000037627
Gene Name regulator of G-protein signalling 22
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03328
Quality Score
Status
Chromosome 15
Chromosomal Location 36009625-36140546 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 36043350 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172831] [ENSMUST00000174881]
AlphaFold G3UYX5
Predicted Effect probably null
Transcript: ENSMUST00000172831
SMART Domains Protein: ENSMUSP00000134259
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 62 76 N/A INTRINSIC
low complexity region 173 179 N/A INTRINSIC
low complexity region 376 391 N/A INTRINSIC
RGS 845 973 3.15e-2 SMART
RGS 1014 1134 1.56e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173018
SMART Domains Protein: ENSMUSP00000133703
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
RGS 4 124 1.56e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174881
SMART Domains Protein: ENSMUSP00000134185
Gene: ENSMUSG00000037627

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 252 267 N/A INTRINSIC
RGS 721 849 3.15e-2 SMART
RGS 890 1010 1.56e-15 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca A T 11: 84,211,355 (GRCm39) M1556L probably benign Het
Aicda T G 6: 122,539,396 (GRCm39) D187E probably benign Het
Arfgap3 A C 15: 83,227,282 (GRCm39) F43L probably damaging Het
AW551984 T C 9: 39,508,412 (GRCm39) E368G probably damaging Het
Bbs4 T C 9: 59,251,401 (GRCm39) E33G probably damaging Het
Bcas1 T A 2: 170,208,316 (GRCm39) K437* probably null Het
Brwd1 A T 16: 95,803,925 (GRCm39) W2082R probably damaging Het
Card6 A T 15: 5,134,927 (GRCm39) probably benign Het
Cd200r4 A G 16: 44,653,882 (GRCm39) I226M possibly damaging Het
Cep57l1 T C 10: 41,619,148 (GRCm39) E73G probably damaging Het
Chaf1a T G 17: 56,370,374 (GRCm39) F613C probably damaging Het
Clybl G T 14: 122,639,406 (GRCm39) K323N probably damaging Het
Coa7 A G 4: 108,195,479 (GRCm39) D136G probably damaging Het
Col5a2 C A 1: 45,415,306 (GRCm39) V1478L possibly damaging Het
Ctnnd2 T C 15: 30,921,993 (GRCm39) probably benign Het
Cyp4f17 T G 17: 32,739,600 (GRCm39) M174R probably damaging Het
Dnah10 A T 5: 124,831,354 (GRCm39) D794V probably benign Het
Eapp A G 12: 54,738,878 (GRCm39) S87P probably benign Het
Efnb3 A G 11: 69,448,031 (GRCm39) I137T probably damaging Het
Eif4e T A 3: 138,259,488 (GRCm39) probably benign Het
Fam83b T A 9: 76,400,324 (GRCm39) I260L probably benign Het
Fras1 A G 5: 96,929,619 (GRCm39) T4008A probably damaging Het
Fut8 A T 12: 77,412,003 (GRCm39) R118W probably damaging Het
Glt1d1 A C 5: 127,734,183 (GRCm39) D119A probably benign Het
Gm3727 T A 14: 7,261,685 (GRCm38) *206C probably null Het
Gmip G A 8: 70,264,261 (GRCm39) V174M possibly damaging Het
Gtf2ird1 A G 5: 134,417,983 (GRCm39) probably null Het
Haao C T 17: 84,154,078 (GRCm39) C23Y probably damaging Het
Hip1 A T 5: 135,453,728 (GRCm39) V400E probably damaging Het
Keg1 A G 19: 12,696,461 (GRCm39) N215S probably damaging Het
Lss T G 10: 76,376,785 (GRCm39) I334S probably damaging Het
Lyn A C 4: 3,745,327 (GRCm39) E77D probably benign Het
Myo3a A G 2: 22,468,210 (GRCm39) E1426G probably benign Het
Ncapg2 A G 12: 116,403,677 (GRCm39) E863G possibly damaging Het
Ncl T C 1: 86,280,319 (GRCm39) Y496C probably damaging Het
Nefm A T 14: 68,358,739 (GRCm39) S432T probably benign Het
Nipsnap1 A G 11: 4,834,096 (GRCm39) Y95C possibly damaging Het
Npc1l1 C A 11: 6,168,643 (GRCm39) E913* probably null Het
Nup205 T C 6: 35,209,349 (GRCm39) L1552P probably damaging Het
Or2t46 A G 11: 58,472,539 (GRCm39) N290D probably damaging Het
Or4c112 G T 2: 88,854,199 (GRCm39) Y49* probably null Het
Or52h7 T A 7: 104,213,677 (GRCm39) V83D probably damaging Het
Or7c70 C T 10: 78,683,201 (GRCm39) E183K probably benign Het
Osm A C 11: 4,188,426 (GRCm39) I18L unknown Het
Otoa T A 7: 120,710,217 (GRCm39) S254R probably damaging Het
Parp1 T C 1: 180,427,155 (GRCm39) probably benign Het
Pcdh17 A G 14: 84,770,551 (GRCm39) I1010V probably benign Het
Peli2 A T 14: 48,490,032 (GRCm39) probably null Het
Pkd1l3 T G 8: 110,388,738 (GRCm39) probably benign Het
Pkhd1 A G 1: 20,151,524 (GRCm39) probably benign Het
Polg2 A C 11: 106,659,163 (GRCm39) V450G probably benign Het
Potegl A T 2: 23,102,817 (GRCm39) Y185F possibly damaging Het
Ptpn13 A T 5: 103,664,214 (GRCm39) T401S probably benign Het
Rttn T G 18: 89,061,152 (GRCm39) S1107A probably benign Het
Scn5a G T 9: 119,366,702 (GRCm39) N328K probably benign Het
Sned1 G A 1: 93,217,089 (GRCm39) A1325T probably benign Het
St8sia4 T A 1: 95,588,595 (GRCm39) E80V probably benign Het
Stard7 T C 2: 127,134,176 (GRCm39) probably benign Het
Suco G T 1: 161,647,990 (GRCm39) P1099T probably damaging Het
Syn2 G T 6: 115,251,221 (GRCm39) C459F probably damaging Het
Tas2r117 A C 6: 132,780,041 (GRCm39) I60L probably benign Het
Tomm70a T C 16: 56,965,150 (GRCm39) C445R probably damaging Het
Tpsab1 T A 17: 25,564,102 (GRCm39) D87V probably benign Het
Trgc4 A G 13: 19,536,416 (GRCm39) Y158C unknown Het
Trpm6 A T 19: 18,815,446 (GRCm39) E1177D possibly damaging Het
Vmn2r71 A T 7: 85,273,499 (GRCm39) D771V probably damaging Het
Vmn2r93 A T 17: 18,525,220 (GRCm39) T293S probably damaging Het
Other mutations in Rgs22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Rgs22 APN 15 36,100,077 (GRCm39) missense possibly damaging 0.93
IGL00594:Rgs22 APN 15 36,083,777 (GRCm39) missense probably benign 0.00
IGL01464:Rgs22 APN 15 36,083,787 (GRCm39) missense possibly damaging 0.90
IGL01686:Rgs22 APN 15 36,103,981 (GRCm39) missense probably benign 0.00
IGL01761:Rgs22 APN 15 36,103,897 (GRCm39) missense probably damaging 0.99
IGL02045:Rgs22 APN 15 36,013,300 (GRCm39) missense probably benign 0.33
IGL02378:Rgs22 APN 15 36,103,951 (GRCm39) missense probably benign 0.00
IGL02490:Rgs22 APN 15 36,054,993 (GRCm39) missense probably damaging 1.00
IGL03219:Rgs22 APN 15 36,107,194 (GRCm39) missense probably damaging 1.00
IGL03229:Rgs22 APN 15 36,015,925 (GRCm39) splice site probably benign
3-1:Rgs22 UTSW 15 36,100,182 (GRCm39) missense possibly damaging 0.48
R0254:Rgs22 UTSW 15 36,104,698 (GRCm39) missense probably damaging 0.99
R0463:Rgs22 UTSW 15 36,093,084 (GRCm39) missense probably damaging 1.00
R0467:Rgs22 UTSW 15 36,099,941 (GRCm39) nonsense probably null
R0486:Rgs22 UTSW 15 36,093,028 (GRCm39) missense probably damaging 0.98
R0554:Rgs22 UTSW 15 36,054,855 (GRCm39) missense probably benign 0.10
R0602:Rgs22 UTSW 15 36,140,018 (GRCm39) splice site probably benign
R0906:Rgs22 UTSW 15 36,104,048 (GRCm39) intron probably benign
R1159:Rgs22 UTSW 15 36,040,839 (GRCm39) missense probably damaging 1.00
R1300:Rgs22 UTSW 15 36,101,908 (GRCm39) missense probably benign 0.43
R1439:Rgs22 UTSW 15 36,025,939 (GRCm39) splice site probably benign
R1491:Rgs22 UTSW 15 36,093,047 (GRCm39) missense probably damaging 0.98
R1502:Rgs22 UTSW 15 36,080,997 (GRCm39) missense probably damaging 1.00
R1514:Rgs22 UTSW 15 36,013,246 (GRCm39) missense probably benign 0.00
R1538:Rgs22 UTSW 15 36,048,922 (GRCm39) missense probably damaging 1.00
R1784:Rgs22 UTSW 15 36,087,582 (GRCm39) missense probably damaging 1.00
R1938:Rgs22 UTSW 15 36,101,950 (GRCm39) missense probably benign 0.00
R1972:Rgs22 UTSW 15 36,103,982 (GRCm39) missense probably benign 0.01
R2109:Rgs22 UTSW 15 36,099,880 (GRCm39) nonsense probably null
R2208:Rgs22 UTSW 15 36,050,378 (GRCm39) missense probably benign 0.01
R3696:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3697:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3698:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3879:Rgs22 UTSW 15 36,107,051 (GRCm39) missense possibly damaging 0.52
R4080:Rgs22 UTSW 15 36,107,222 (GRCm39) missense probably damaging 1.00
R4363:Rgs22 UTSW 15 36,104,020 (GRCm39) missense probably damaging 0.99
R4591:Rgs22 UTSW 15 36,100,282 (GRCm39) missense probably benign 0.01
R4673:Rgs22 UTSW 15 36,100,079 (GRCm39) missense probably benign 0.04
R4829:Rgs22 UTSW 15 36,104,034 (GRCm39) missense probably damaging 1.00
R4831:Rgs22 UTSW 15 36,050,294 (GRCm39) missense probably benign 0.00
R4865:Rgs22 UTSW 15 36,100,358 (GRCm39) missense probably damaging 1.00
R4907:Rgs22 UTSW 15 36,087,570 (GRCm39) missense possibly damaging 0.61
R4944:Rgs22 UTSW 15 36,026,088 (GRCm39) missense possibly damaging 0.83
R4975:Rgs22 UTSW 15 36,055,022 (GRCm39) nonsense probably null
R5056:Rgs22 UTSW 15 36,050,391 (GRCm39) splice site probably null
R5126:Rgs22 UTSW 15 36,040,790 (GRCm39) missense probably damaging 0.96
R5138:Rgs22 UTSW 15 36,099,934 (GRCm39) missense probably benign 0.04
R5444:Rgs22 UTSW 15 36,015,773 (GRCm39) missense possibly damaging 0.83
R5507:Rgs22 UTSW 15 36,099,798 (GRCm39) missense probably damaging 0.99
R5640:Rgs22 UTSW 15 36,107,101 (GRCm39) missense probably benign 0.00
R5969:Rgs22 UTSW 15 36,015,782 (GRCm39) missense probably benign 0.00
R6005:Rgs22 UTSW 15 36,010,713 (GRCm39) missense probably benign 0.39
R6053:Rgs22 UTSW 15 36,100,153 (GRCm39) missense probably benign 0.04
R6134:Rgs22 UTSW 15 36,107,194 (GRCm39) missense probably damaging 1.00
R6230:Rgs22 UTSW 15 36,100,176 (GRCm39) missense probably benign 0.02
R6295:Rgs22 UTSW 15 36,087,520 (GRCm39) missense probably benign 0.00
R6352:Rgs22 UTSW 15 36,093,067 (GRCm39) missense probably damaging 1.00
R6809:Rgs22 UTSW 15 36,048,910 (GRCm39) missense probably damaging 1.00
R6900:Rgs22 UTSW 15 36,010,893 (GRCm39) missense possibly damaging 0.61
R6947:Rgs22 UTSW 15 36,104,036 (GRCm39) critical splice acceptor site probably null
R7102:Rgs22 UTSW 15 36,122,459 (GRCm39) missense probably damaging 1.00
R7126:Rgs22 UTSW 15 36,103,954 (GRCm39) missense probably damaging 0.97
R7263:Rgs22 UTSW 15 36,015,789 (GRCm39) missense possibly damaging 0.86
R7623:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R7732:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R7748:Rgs22 UTSW 15 36,122,415 (GRCm39) critical splice donor site probably null
R7771:Rgs22 UTSW 15 36,050,224 (GRCm39) missense possibly damaging 0.94
R7835:Rgs22 UTSW 15 36,082,057 (GRCm39) critical splice donor site probably null
R7849:Rgs22 UTSW 15 36,099,858 (GRCm39) missense probably damaging 1.00
R7954:Rgs22 UTSW 15 36,082,148 (GRCm39) missense possibly damaging 0.75
R8384:Rgs22 UTSW 15 36,046,158 (GRCm39) critical splice donor site probably null
R8516:Rgs22 UTSW 15 36,010,481 (GRCm39) makesense probably null
R8904:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R8923:Rgs22 UTSW 15 36,093,106 (GRCm39) missense probably damaging 1.00
R9287:Rgs22 UTSW 15 36,098,409 (GRCm39) missense probably damaging 1.00
R9324:Rgs22 UTSW 15 36,087,544 (GRCm39) missense probably benign
R9660:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R9679:Rgs22 UTSW 15 36,087,587 (GRCm39) missense probably benign 0.00
R9728:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
RF035:Rgs22 UTSW 15 36,010,981 (GRCm39) critical splice acceptor site probably benign
RF043:Rgs22 UTSW 15 36,010,982 (GRCm39) critical splice acceptor site probably benign
Posted On 2016-08-02