Incidental Mutation 'IGL03334:Vmn2r35'
ID 416947
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r35
Ensembl Gene ENSMUSG00000096399
Gene Name vomeronasal 2, receptor 35
Synonyms EG625353
Accession Numbers
Essential gene? Not available question?
Stock # IGL03334
Quality Score
Status
Chromosome 7
Chromosomal Location 7789150-7822866 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 7789493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 748 (Y748F)
Ref Sequence ENSEMBL: ENSMUSP00000133007 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169683]
AlphaFold E9Q7U8
Predicted Effect probably damaging
Transcript: ENSMUST00000169683
AA Change: Y748F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133007
Gene: ENSMUSG00000096399
AA Change: Y748F

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 1.8e-32 PFAM
Pfam:NCD3G 512 565 1.2e-18 PFAM
Pfam:7tm_3 595 833 2.4e-55 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 A G 11: 48,838,302 (GRCm39) F762L probably benign Het
Angpt1 T A 15: 42,359,808 (GRCm39) E208V possibly damaging Het
Arhgef18 A T 8: 3,438,023 (GRCm39) I286F probably benign Het
Arhgef5 T C 6: 43,250,934 (GRCm39) S562P possibly damaging Het
Asb6 T C 2: 30,714,496 (GRCm39) T205A probably benign Het
B4galnt4 G A 7: 140,647,354 (GRCm39) probably null Het
Clca4a A T 3: 144,659,627 (GRCm39) M743K probably benign Het
Col14a1 T C 15: 55,312,217 (GRCm39) probably benign Het
Col27a1 A T 4: 63,232,959 (GRCm39) Y359F probably damaging Het
Dhcr7 T A 7: 143,394,234 (GRCm39) V125D possibly damaging Het
Ercc3 T C 18: 32,373,890 (GRCm39) probably null Het
Fnbp1l A G 3: 122,351,598 (GRCm39) V315A probably benign Het
Gm17174 T A 14: 51,829,420 (GRCm39) R48* probably null Het
Golga4 C T 9: 118,366,301 (GRCm39) probably benign Het
Grin1 C T 2: 25,188,405 (GRCm39) probably null Het
Ifi203 T A 1: 173,765,401 (GRCm39) K58* probably null Het
Ighv2-9-1 A G 12: 113,733,543 (GRCm39) S93P probably benign Het
Il27ra A G 8: 84,757,751 (GRCm39) V594A probably benign Het
Krr1 T G 10: 111,815,959 (GRCm39) S275R probably benign Het
Lars1 T C 18: 42,354,571 (GRCm39) D792G probably benign Het
Myo1f G A 17: 33,817,168 (GRCm39) R737H probably damaging Het
Nebl T A 2: 17,418,522 (GRCm39) H292L probably damaging Het
Nell1 C A 7: 49,712,359 (GRCm39) probably null Het
Nktr T C 9: 121,577,242 (GRCm39) F412L probably benign Het
Nlrp3 T A 11: 59,439,842 (GRCm39) I473N probably damaging Het
Or1j10 T C 2: 36,267,063 (GRCm39) Y92H possibly damaging Het
Phf3 A G 1: 30,844,810 (GRCm39) V1383A probably damaging Het
Prss48 T C 3: 85,904,625 (GRCm39) E191G probably damaging Het
Psg25 T A 7: 18,263,699 (GRCm39) L41F probably benign Het
Sema3b A G 9: 107,481,276 (GRCm39) L78P probably damaging Het
Spen G T 4: 141,197,280 (GRCm39) N3496K probably damaging Het
Tbk1 A T 10: 121,420,104 (GRCm39) H28Q possibly damaging Het
Trpv3 T A 11: 73,172,491 (GRCm39) probably benign Het
Vmn1r218 T C 13: 23,320,788 (GRCm39) L45P probably damaging Het
Vps18 C T 2: 119,127,963 (GRCm39) R929W probably damaging Het
Xpnpep1 T C 19: 52,998,577 (GRCm39) K224E probably damaging Het
Zbed5 T A 5: 129,931,196 (GRCm39) F382I possibly damaging Het
Other mutations in Vmn2r35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01875:Vmn2r35 APN 7 7,819,772 (GRCm39) splice site probably benign
R1858:Vmn2r35 UTSW 7 7,819,805 (GRCm39) missense possibly damaging 0.46
R5505:Vmn2r35 UTSW 7 7,789,479 (GRCm39) missense probably damaging 1.00
R6150:Vmn2r35 UTSW 7 7,789,555 (GRCm39) missense probably damaging 1.00
R6211:Vmn2r35 UTSW 7 7,789,527 (GRCm39) missense probably damaging 0.99
R7439:Vmn2r35 UTSW 7 7,820,013 (GRCm39) missense probably damaging 1.00
R8399:Vmn2r35 UTSW 7 7,819,897 (GRCm39) missense probably benign 0.00
R9628:Vmn2r35 UTSW 7 7,815,702 (GRCm39) missense probably benign
Posted On 2016-08-02