Incidental Mutation 'IGL03334:Psg25'
| ID |
416951 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Psg25
|
| Ensembl Gene |
ENSMUSG00000070798 |
| Gene Name |
pregnancy-specific glycoprotein 25 |
| Synonyms |
cea13 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
IGL03334
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
18519702-18532269 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 18529774 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 41
(L41F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092389
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094795]
|
| AlphaFold |
Q497W1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094795
AA Change: L41F
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000092389
Gene: ENSMUSG00000070798
AA Change: L41F
| Domain | Start | End | E-Value | Type |
|---|
|
IG
|
40 |
141 |
2.15e-3 |
SMART |
|
IG
|
160 |
261 |
1.55e0 |
SMART |
|
IG
|
280 |
381 |
3.59e-5 |
SMART |
|
IGc2
|
397 |
461 |
1.02e-9 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930111J21Rik1 |
A |
G |
11: 48,947,475 (GRCm38) |
F762L |
probably benign |
Het |
| A430078G23Rik |
A |
T |
8: 3,388,023 (GRCm38) |
I286F |
probably benign |
Het |
| Angpt1 |
T |
A |
15: 42,496,412 (GRCm38) |
E208V |
possibly damaging |
Het |
| Arhgef5 |
T |
C |
6: 43,274,000 (GRCm38) |
S562P |
possibly damaging |
Het |
| Asb6 |
T |
C |
2: 30,824,484 (GRCm38) |
T205A |
probably benign |
Het |
| B4galnt4 |
G |
A |
7: 141,067,441 (GRCm38) |
|
probably null |
Het |
| Clca4a |
A |
T |
3: 144,953,866 (GRCm38) |
M743K |
probably benign |
Het |
| Col14a1 |
T |
C |
15: 55,448,821 (GRCm38) |
|
probably benign |
Het |
| Col27a1 |
A |
T |
4: 63,314,722 (GRCm38) |
Y359F |
probably damaging |
Het |
| Dhcr7 |
T |
A |
7: 143,840,497 (GRCm38) |
V125D |
possibly damaging |
Het |
| Ercc3 |
T |
C |
18: 32,240,837 (GRCm38) |
|
probably null |
Het |
| Fnbp1l |
A |
G |
3: 122,557,949 (GRCm38) |
V315A |
probably benign |
Het |
| Gm17174 |
T |
A |
14: 51,591,963 (GRCm38) |
R48* |
probably null |
Het |
| Golga4 |
C |
T |
9: 118,537,233 (GRCm38) |
|
probably benign |
Het |
| Grin1 |
C |
T |
2: 25,298,393 (GRCm38) |
|
probably null |
Het |
| Ifi203 |
T |
A |
1: 173,937,835 (GRCm38) |
K58* |
probably null |
Het |
| Ighv2-9-1 |
A |
G |
12: 113,769,923 (GRCm38) |
S93P |
probably benign |
Het |
| Il27ra |
A |
G |
8: 84,031,122 (GRCm38) |
V594A |
probably benign |
Het |
| Krr1 |
T |
G |
10: 111,980,054 (GRCm38) |
S275R |
probably benign |
Het |
| Lars |
T |
C |
18: 42,221,506 (GRCm38) |
D792G |
probably benign |
Het |
| Myo1f |
G |
A |
17: 33,598,194 (GRCm38) |
R737H |
probably damaging |
Het |
| Nebl |
T |
A |
2: 17,413,711 (GRCm38) |
H292L |
probably damaging |
Het |
| Nell1 |
C |
A |
7: 50,062,611 (GRCm38) |
|
probably null |
Het |
| Nktr |
T |
C |
9: 121,748,176 (GRCm38) |
F412L |
probably benign |
Het |
| Nlrp3 |
T |
A |
11: 59,549,016 (GRCm38) |
I473N |
probably damaging |
Het |
| Olfr338 |
T |
C |
2: 36,377,051 (GRCm38) |
Y92H |
possibly damaging |
Het |
| Phf3 |
A |
G |
1: 30,805,729 (GRCm38) |
V1383A |
probably damaging |
Het |
| Prss48 |
T |
C |
3: 85,997,318 (GRCm38) |
E191G |
probably damaging |
Het |
| Sema3b |
A |
G |
9: 107,604,077 (GRCm38) |
L78P |
probably damaging |
Het |
| Spen |
G |
T |
4: 141,469,969 (GRCm38) |
N3496K |
probably damaging |
Het |
| Tbk1 |
A |
T |
10: 121,584,199 (GRCm38) |
H28Q |
possibly damaging |
Het |
| Trpv3 |
T |
A |
11: 73,281,665 (GRCm38) |
|
probably benign |
Het |
| Vmn1r218 |
T |
C |
13: 23,136,618 (GRCm38) |
L45P |
probably damaging |
Het |
| Vmn2r35 |
T |
A |
7: 7,786,494 (GRCm38) |
Y748F |
probably damaging |
Het |
| Vps18 |
C |
T |
2: 119,297,482 (GRCm38) |
R929W |
probably damaging |
Het |
| Xpnpep1 |
T |
C |
19: 53,010,146 (GRCm38) |
K224E |
probably damaging |
Het |
| Zbed5 |
T |
A |
5: 129,902,355 (GRCm38) |
F382I |
possibly damaging |
Het |
|
| Other mutations in Psg25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00231:Psg25
|
APN |
7 |
18,526,181 (GRCm38) |
splice site |
probably benign |
|
|
IGL00508:Psg25
|
APN |
7 |
18,529,731 (GRCm38) |
missense |
probably benign |
|
|
IGL01154:Psg25
|
APN |
7 |
18,524,699 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL01388:Psg25
|
APN |
7 |
18,529,665 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
IGL02222:Psg25
|
APN |
7 |
18,529,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02261:Psg25
|
APN |
7 |
18,521,343 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02309:Psg25
|
APN |
7 |
18,526,424 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02803:Psg25
|
APN |
7 |
18,526,287 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R0711:Psg25
|
UTSW |
7 |
18,529,560 (GRCm38) |
nonsense |
probably null |
|
|
R1458:Psg25
|
UTSW |
7 |
18,529,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1598:Psg25
|
UTSW |
7 |
18,532,003 (GRCm38) |
nonsense |
probably null |
|
|
R2064:Psg25
|
UTSW |
7 |
18,521,253 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2066:Psg25
|
UTSW |
7 |
18,529,562 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4485:Psg25
|
UTSW |
7 |
18,526,278 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4499:Psg25
|
UTSW |
7 |
18,524,891 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4514:Psg25
|
UTSW |
7 |
18,529,608 (GRCm38) |
nonsense |
probably null |
|
|
R4547:Psg25
|
UTSW |
7 |
18,524,704 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4604:Psg25
|
UTSW |
7 |
18,529,803 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4886:Psg25
|
UTSW |
7 |
18,524,913 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5121:Psg25
|
UTSW |
7 |
18,526,536 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R5208:Psg25
|
UTSW |
7 |
18,526,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5267:Psg25
|
UTSW |
7 |
18,524,786 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R5376:Psg25
|
UTSW |
7 |
18,526,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5425:Psg25
|
UTSW |
7 |
18,524,784 (GRCm38) |
nonsense |
probably null |
|
|
R5749:Psg25
|
UTSW |
7 |
18,524,851 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6050:Psg25
|
UTSW |
7 |
18,526,478 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6862:Psg25
|
UTSW |
7 |
18,521,398 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6962:Psg25
|
UTSW |
7 |
18,529,754 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7238:Psg25
|
UTSW |
7 |
18,532,202 (GRCm38) |
start gained |
probably benign |
|
|
R7782:Psg25
|
UTSW |
7 |
18,521,302 (GRCm38) |
missense |
probably benign |
0.15 |
|
R7812:Psg25
|
UTSW |
7 |
18,521,168 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R8155:Psg25
|
UTSW |
7 |
18,526,520 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8775:Psg25
|
UTSW |
7 |
18,521,228 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8775-TAIL:Psg25
|
UTSW |
7 |
18,521,228 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8865:Psg25
|
UTSW |
7 |
18,529,594 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R9013:Psg25
|
UTSW |
7 |
18,524,765 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9755:Psg25
|
UTSW |
7 |
18,526,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1088:Psg25
|
UTSW |
7 |
18,529,591 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation