Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03334:Psg25'

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416951

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg25

Ensembl Gene

ENSMUSG00000070798

Gene Name

pregnancy-specific glycoprotein 25

Synonyms

cea13

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

IGL03334

Quality Score

Status

Chromosome

Chromosomal Location

18519702-18532269 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18529774 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 41 (L41F)

Ref Sequence

ENSEMBL: ENSMUSP00000092389 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094795]

Predicted Effect

probably benign
Transcript: ENSMUST00000094795
AA Change: L41F

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000092389
Gene: ENSMUSG00000070798
AA Change: L41F

Domain	Start	End	E-Value	Type
IG	40	141	2.15e-3	SMART
IG	160	261	1.55e0	SMART
IG	280	381	3.59e-5	SMART
IGc2	397	461	1.02e-9	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930111J21Rik1	A	G	11: 48,947,475	F762L	probably benign	Het
A430078G23Rik	A	T	8: 3,388,023	I286F	probably benign	Het
Angpt1	T	A	15: 42,496,412	E208V	possibly damaging	Het
Arhgef5	T	C	6: 43,274,000	S562P	possibly damaging	Het
Asb6	T	C	2: 30,824,484	T205A	probably benign	Het
B4galnt4	G	A	7: 141,067,441		probably null	Het
Clca4a	A	T	3: 144,953,866	M743K	probably benign	Het
Col14a1	T	C	15: 55,448,821		probably benign	Het
Col27a1	A	T	4: 63,314,722	Y359F	probably damaging	Het
Dhcr7	T	A	7: 143,840,497	V125D	possibly damaging	Het
Ercc3	T	C	18: 32,240,837		probably null	Het
Fnbp1l	A	G	3: 122,557,949	V315A	probably benign	Het
Gm17174	T	A	14: 51,591,963	R48*	probably null	Het
Golga4	C	T	9: 118,537,233		probably benign	Het
Grin1	C	T	2: 25,298,393		probably null	Het
Ifi203	T	A	1: 173,937,835	K58*	probably null	Het
Ighv2-9-1	A	G	12: 113,769,923	S93P	probably benign	Het
Il27ra	A	G	8: 84,031,122	V594A	probably benign	Het
Krr1	T	G	10: 111,980,054	S275R	probably benign	Het
Lars	T	C	18: 42,221,506	D792G	probably benign	Het
Myo1f	G	A	17: 33,598,194	R737H	probably damaging	Het
Nebl	T	A	2: 17,413,711	H292L	probably damaging	Het
Nell1	C	A	7: 50,062,611		probably null	Het
Nktr	T	C	9: 121,748,176	F412L	probably benign	Het
Nlrp3	T	A	11: 59,549,016	I473N	probably damaging	Het
Olfr338	T	C	2: 36,377,051	Y92H	possibly damaging	Het
Phf3	A	G	1: 30,805,729	V1383A	probably damaging	Het
Prss48	T	C	3: 85,997,318	E191G	probably damaging	Het
Sema3b	A	G	9: 107,604,077	L78P	probably damaging	Het
Spen	G	T	4: 141,469,969	N3496K	probably damaging	Het
Tbk1	A	T	10: 121,584,199	H28Q	possibly damaging	Het
Trpv3	T	A	11: 73,281,665		probably benign	Het
Vmn1r218	T	C	13: 23,136,618	L45P	probably damaging	Het
Vmn2r35	T	A	7: 7,786,494	Y748F	probably damaging	Het
Vps18	C	T	2: 119,297,482	R929W	probably damaging	Het
Xpnpep1	T	C	19: 53,010,146	K224E	probably damaging	Het
Zbed5	T	A	5: 129,902,355	F382I	possibly damaging	Het

Other mutations in Psg25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00231:Psg25	APN	7	18526181	splice site	probably benign
IGL00508:Psg25	APN	7	18529731	missense	probably benign
IGL01154:Psg25	APN	7	18524699	missense	probably benign	0.01
IGL01388:Psg25	APN	7	18529665	missense	possibly damaging	0.87
IGL02222:Psg25	APN	7	18529727	missense	probably damaging	1.00
IGL02261:Psg25	APN	7	18521343	missense	probably benign	0.09
IGL02309:Psg25	APN	7	18526424	missense	probably damaging	0.98
IGL02803:Psg25	APN	7	18526287	missense	possibly damaging	0.47
R0711:Psg25	UTSW	7	18529560	nonsense	probably null
R1458:Psg25	UTSW	7	18529587	missense	probably damaging	1.00
R1598:Psg25	UTSW	7	18532003	nonsense	probably null
R2064:Psg25	UTSW	7	18521253	missense	probably damaging	0.96
R2066:Psg25	UTSW	7	18529562	missense	probably damaging	1.00
R4485:Psg25	UTSW	7	18526278	missense	probably damaging	1.00
R4499:Psg25	UTSW	7	18524891	missense	possibly damaging	0.89
R4514:Psg25	UTSW	7	18529608	nonsense	probably null
R4547:Psg25	UTSW	7	18524704	missense	probably damaging	1.00
R4604:Psg25	UTSW	7	18529803	missense	probably benign	0.05
R4886:Psg25	UTSW	7	18524913	missense	probably benign	0.00
R5121:Psg25	UTSW	7	18526536	missense	possibly damaging	0.68
R5208:Psg25	UTSW	7	18526535	missense	probably benign	0.00
R5267:Psg25	UTSW	7	18524786	missense	possibly damaging	0.78
R5376:Psg25	UTSW	7	18526535	missense	probably benign	0.00
R5425:Psg25	UTSW	7	18524784	nonsense	probably null
R5749:Psg25	UTSW	7	18524851	missense	probably damaging	1.00
R6050:Psg25	UTSW	7	18526478	missense	probably benign	0.37
R6862:Psg25	UTSW	7	18521398	missense	probably benign	0.03
R6962:Psg25	UTSW	7	18529754	missense	probably damaging	1.00
R7238:Psg25	UTSW	7	18532202	start gained	probably benign
R7782:Psg25	UTSW	7	18521302	missense	probably benign	0.15
R7812:Psg25	UTSW	7	18521168	missense	possibly damaging	0.71
R8155:Psg25	UTSW	7	18526520	missense	probably benign	0.00
Z1088:Psg25	UTSW	7	18529591	missense	probably benign	0.00

Posted On

2016-08-02