Incidental Mutation 'IGL03335:Zfp352'
| ID |
416991 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp352
|
| Ensembl Gene |
ENSMUSG00000070902 |
| Gene Name |
zinc finger protein 352 |
| Synonyms |
2czf48 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03335
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
90218820-90225702 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 90224346 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 241
(F241S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102746
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080541]
[ENSMUST00000107129]
|
| AlphaFold |
A2AML7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000080541
AA Change: F241S
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000079383
Gene: ENSMUSG00000070902
AA Change: F241S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
459 |
483 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
489 |
513 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
519 |
542 |
1.76e-1 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000107129
AA Change: F241S
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000102746
Gene: ENSMUSG00000070902
AA Change: F241S
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
459 |
483 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
489 |
513 |
8.22e-2 |
SMART |
|
ZnF_C2H2
|
519 |
542 |
1.76e-1 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
T |
C |
5: 8,935,258 (GRCm38) |
V713A |
probably benign |
Het |
| Actr8 |
T |
C |
14: 29,978,557 (GRCm38) |
V31A |
probably benign |
Het |
| Alcam |
A |
C |
16: 52,291,003 (GRCm38) |
Y244* |
probably null |
Het |
| Ankrd24 |
A |
G |
10: 81,647,133 (GRCm38) |
S972G |
probably benign |
Het |
| Aox1 |
T |
A |
1: 58,076,160 (GRCm38) |
V768E |
probably damaging |
Het |
| Btbd11 |
A |
T |
10: 85,658,358 (GRCm38) |
|
probably benign |
Het |
| C130060K24Rik |
T |
C |
6: 65,453,117 (GRCm38) |
|
probably null |
Het |
| Carmil2 |
A |
G |
8: 105,697,029 (GRCm38) |
I1212V |
probably benign |
Het |
| Catsper1 |
C |
T |
19: 5,336,311 (GRCm38) |
R191C |
probably damaging |
Het |
| Cenpe |
T |
A |
3: 135,243,625 (GRCm38) |
V57D |
probably benign |
Het |
| Cpsf3 |
T |
C |
12: 21,306,887 (GRCm38) |
|
probably null |
Het |
| Cubn |
A |
G |
2: 13,360,329 (GRCm38) |
S1633P |
probably damaging |
Het |
| Dsg1c |
G |
A |
18: 20,283,697 (GRCm38) |
R885Q |
probably benign |
Het |
| Egfl6 |
C |
A |
X: 166,538,693 (GRCm38) |
G272W |
probably damaging |
Het |
| Ermard |
T |
C |
17: 15,059,406 (GRCm38) |
L486P |
probably damaging |
Het |
| F13b |
A |
T |
1: 139,522,386 (GRCm38) |
L595F |
probably damaging |
Het |
| Foxm1 |
A |
G |
6: 128,372,568 (GRCm38) |
N350S |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,733,944 (GRCm38) |
|
probably benign |
Het |
| Gpr152 |
C |
A |
19: 4,143,771 (GRCm38) |
T437N |
possibly damaging |
Het |
| Icmt |
T |
A |
4: 152,300,697 (GRCm38) |
Y205* |
probably null |
Het |
| Ints8 |
A |
T |
4: 11,216,460 (GRCm38) |
F844I |
probably damaging |
Het |
| Mep1a |
T |
A |
17: 43,477,173 (GRCm38) |
D664V |
possibly damaging |
Het |
| Muc4 |
T |
A |
16: 32,753,021 (GRCm38) |
N966K |
probably benign |
Het |
| Myo7b |
T |
A |
18: 31,985,020 (GRCm38) |
Q851L |
possibly damaging |
Het |
| Pdzd2 |
T |
C |
15: 12,373,764 (GRCm38) |
H2095R |
probably benign |
Het |
| Phldb1 |
A |
G |
9: 44,728,069 (GRCm38) |
L4P |
possibly damaging |
Het |
| Pkd1l2 |
G |
A |
8: 117,065,745 (GRCm38) |
T436I |
probably benign |
Het |
| Pnpla8 |
T |
A |
12: 44,283,164 (GRCm38) |
N166K |
probably benign |
Het |
| Rapgef2 |
A |
G |
3: 79,099,185 (GRCm38) |
M137T |
probably damaging |
Het |
| Rbm15b |
G |
A |
9: 106,884,339 (GRCm38) |
H877Y |
probably damaging |
Het |
| Rbm45 |
T |
C |
2: 76,376,433 (GRCm38) |
L263P |
probably damaging |
Het |
| Rprd1b |
T |
C |
2: 158,074,964 (GRCm38) |
V288A |
probably damaging |
Het |
| Tmtc3 |
C |
A |
10: 100,466,254 (GRCm38) |
V278L |
probably damaging |
Het |
| Tomm70a |
A |
G |
16: 57,149,926 (GRCm38) |
T556A |
probably damaging |
Het |
| Trpc7 |
T |
C |
13: 56,887,691 (GRCm38) |
E143G |
probably damaging |
Het |
| Trpm3 |
G |
T |
19: 22,926,071 (GRCm38) |
|
probably null |
Het |
| Ugt2b34 |
T |
C |
5: 86,906,640 (GRCm38) |
E94G |
probably benign |
Het |
| Vmn1r174 |
T |
C |
7: 23,754,512 (GRCm38) |
V201A |
probably benign |
Het |
|
| Other mutations in Zfp352 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01963:Zfp352
|
APN |
4 |
90,224,154 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02252:Zfp352
|
APN |
4 |
90,224,130 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL03156:Zfp352
|
APN |
4 |
90,224,087 (GRCm38) |
missense |
possibly damaging |
0.57 |
|
IGL03167:Zfp352
|
APN |
4 |
90,224,702 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03190:Zfp352
|
APN |
4 |
90,223,757 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R0051:Zfp352
|
UTSW |
4 |
90,224,285 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0403:Zfp352
|
UTSW |
4 |
90,225,009 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R0550:Zfp352
|
UTSW |
4 |
90,224,690 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0671:Zfp352
|
UTSW |
4 |
90,223,919 (GRCm38) |
missense |
probably benign |
|
|
R1034:Zfp352
|
UTSW |
4 |
90,224,156 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1754:Zfp352
|
UTSW |
4 |
90,223,809 (GRCm38) |
missense |
probably benign |
0.23 |
|
R2016:Zfp352
|
UTSW |
4 |
90,225,171 (GRCm38) |
missense |
probably benign |
0.42 |
|
R2064:Zfp352
|
UTSW |
4 |
90,225,120 (GRCm38) |
missense |
probably benign |
0.08 |
|
R2308:Zfp352
|
UTSW |
4 |
90,225,243 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3552:Zfp352
|
UTSW |
4 |
90,225,102 (GRCm38) |
missense |
probably benign |
0.33 |
|
R3794:Zfp352
|
UTSW |
4 |
90,225,149 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3795:Zfp352
|
UTSW |
4 |
90,225,149 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4135:Zfp352
|
UTSW |
4 |
90,225,024 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4356:Zfp352
|
UTSW |
4 |
90,223,834 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4409:Zfp352
|
UTSW |
4 |
90,225,164 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4590:Zfp352
|
UTSW |
4 |
90,224,535 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4614:Zfp352
|
UTSW |
4 |
90,225,081 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4617:Zfp352
|
UTSW |
4 |
90,225,081 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4618:Zfp352
|
UTSW |
4 |
90,225,081 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4741:Zfp352
|
UTSW |
4 |
90,224,940 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4931:Zfp352
|
UTSW |
4 |
90,224,304 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4959:Zfp352
|
UTSW |
4 |
90,224,139 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4973:Zfp352
|
UTSW |
4 |
90,224,139 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5167:Zfp352
|
UTSW |
4 |
90,224,216 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5260:Zfp352
|
UTSW |
4 |
90,224,460 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5524:Zfp352
|
UTSW |
4 |
90,225,104 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5942:Zfp352
|
UTSW |
4 |
90,225,070 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6802:Zfp352
|
UTSW |
4 |
90,225,200 (GRCm38) |
missense |
probably benign |
0.33 |
|
R6819:Zfp352
|
UTSW |
4 |
90,224,699 (GRCm38) |
missense |
probably benign |
|
|
R7072:Zfp352
|
UTSW |
4 |
90,224,424 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7099:Zfp352
|
UTSW |
4 |
90,224,880 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7569:Zfp352
|
UTSW |
4 |
90,223,659 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R7645:Zfp352
|
UTSW |
4 |
90,224,777 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7705:Zfp352
|
UTSW |
4 |
90,225,275 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8424:Zfp352
|
UTSW |
4 |
90,224,243 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R9180:Zfp352
|
UTSW |
4 |
90,224,881 (GRCm38) |
missense |
probably benign |
0.38 |
|
R9378:Zfp352
|
UTSW |
4 |
90,224,338 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9509:Zfp352
|
UTSW |
4 |
90,224,706 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9623:Zfp352
|
UTSW |
4 |
90,224,891 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation