Incidental Mutation 'IGL03335:Gpr152'
ID417009
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr152
Ensembl Gene ENSMUSG00000044724
Gene NameG protein-coupled receptor 152
SynonymsA930009H15Rik, LOC269053
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03335
Quality Score
Status
Chromosome19
Chromosomal Location4139799-4145738 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 4143771 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Asparagine at position 437 (T437N)
Ref Sequence ENSEMBL: ENSMUSP00000094062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008893] [ENSMUST00000025761] [ENSMUST00000096338] [ENSMUST00000123874]
Predicted Effect probably benign
Transcript: ENSMUST00000008893
SMART Domains Protein: ENSMUSP00000008893
Gene: ENSMUSG00000024835

DomainStartEndE-ValueType
DUF1899 5 69 1.48e-37 SMART
WD40 68 111 2.1e-7 SMART
WD40 121 161 1.44e-5 SMART
WD40 164 204 4.08e-5 SMART
DUF1900 258 392 6.41e-88 SMART
coiled coil region 445 482 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000025761
SMART Domains Protein: ENSMUSP00000025761
Gene: ENSMUSG00000024842

DomainStartEndE-ValueType
low complexity region 45 67 N/A INTRINSIC
low complexity region 79 97 N/A INTRINSIC
EFh 129 157 1.08e-6 SMART
Blast:EFh 165 193 2e-7 BLAST
EFh 206 234 1.05e-4 SMART
EFh 243 271 1.55e-7 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000096338
AA Change: T437N

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000094062
Gene: ENSMUSG00000044724
AA Change: T437N

DomainStartEndE-ValueType
Pfam:7tm_1 47 295 7e-19 PFAM
low complexity region 347 361 N/A INTRINSIC
low complexity region 419 433 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000123874
SMART Domains Protein: ENSMUSP00000118450
Gene: ENSMUSG00000024835

DomainStartEndE-ValueType
DUF1899 5 69 1.48e-37 SMART
WD40 68 111 2.1e-7 SMART
WD40 121 161 1.44e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134194
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142878
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143613
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148733
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T C 5: 8,935,258 V713A probably benign Het
Actr8 T C 14: 29,978,557 V31A probably benign Het
Alcam A C 16: 52,291,003 Y244* probably null Het
Ankrd24 A G 10: 81,647,133 S972G probably benign Het
Aox1 T A 1: 58,076,160 V768E probably damaging Het
Btbd11 A T 10: 85,658,358 probably benign Het
C130060K24Rik T C 6: 65,453,117 probably null Het
Carmil2 A G 8: 105,697,029 I1212V probably benign Het
Catsper1 C T 19: 5,336,311 R191C probably damaging Het
Cenpe T A 3: 135,243,625 V57D probably benign Het
Cpsf3 T C 12: 21,306,887 probably null Het
Cubn A G 2: 13,360,329 S1633P probably damaging Het
Dsg1c G A 18: 20,283,697 R885Q probably benign Het
Egfl6 C A X: 166,538,693 G272W probably damaging Het
Ermard T C 17: 15,059,406 L486P probably damaging Het
F13b A T 1: 139,522,386 L595F probably damaging Het
Foxm1 A G 6: 128,372,568 N350S possibly damaging Het
Fras1 T C 5: 96,733,944 probably benign Het
Icmt T A 4: 152,300,697 Y205* probably null Het
Ints8 A T 4: 11,216,460 F844I probably damaging Het
Mep1a T A 17: 43,477,173 D664V possibly damaging Het
Muc4 T A 16: 32,753,021 N966K probably benign Het
Myo7b T A 18: 31,985,020 Q851L possibly damaging Het
Pdzd2 T C 15: 12,373,764 H2095R probably benign Het
Phldb1 A G 9: 44,728,069 L4P possibly damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Pnpla8 T A 12: 44,283,164 N166K probably benign Het
Rapgef2 A G 3: 79,099,185 M137T probably damaging Het
Rbm15b G A 9: 106,884,339 H877Y probably damaging Het
Rbm45 T C 2: 76,376,433 L263P probably damaging Het
Rprd1b T C 2: 158,074,964 V288A probably damaging Het
Tmtc3 C A 10: 100,466,254 V278L probably damaging Het
Tomm70a A G 16: 57,149,926 T556A probably damaging Het
Trpc7 T C 13: 56,887,691 E143G probably damaging Het
Trpm3 G T 19: 22,926,071 probably null Het
Ugt2b34 T C 5: 86,906,640 E94G probably benign Het
Vmn1r174 T C 7: 23,754,512 V201A probably benign Het
Zfp352 T C 4: 90,224,346 F241S probably damaging Het
Other mutations in Gpr152
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:Gpr152 APN 19 4143507 missense probably benign
IGL01400:Gpr152 APN 19 4143627 missense probably benign 0.33
IGL01538:Gpr152 APN 19 4142952 missense probably damaging 1.00
IGL02288:Gpr152 APN 19 4143695 missense probably benign
IGL02513:Gpr152 APN 19 4142844 missense probably damaging 1.00
R0318:Gpr152 UTSW 19 4143542 missense possibly damaging 0.73
R1216:Gpr152 UTSW 19 4143555 missense possibly damaging 0.86
R1936:Gpr152 UTSW 19 4142532 missense probably damaging 1.00
R2248:Gpr152 UTSW 19 4143806 missense probably benign 0.00
R3161:Gpr152 UTSW 19 4142714 missense probably benign 0.00
R4193:Gpr152 UTSW 19 4142907 missense probably damaging 1.00
R4719:Gpr152 UTSW 19 4143224 missense possibly damaging 0.92
R4852:Gpr152 UTSW 19 4143791 missense probably benign 0.00
R5014:Gpr152 UTSW 19 4143507 missense probably benign 0.00
R5381:Gpr152 UTSW 19 4142517 missense probably damaging 1.00
R5431:Gpr152 UTSW 19 4143747 missense probably benign 0.21
R5470:Gpr152 UTSW 19 4143129 missense probably damaging 1.00
R7331:Gpr152 UTSW 19 4142609 missense probably damaging 0.99
R7350:Gpr152 UTSW 19 4142964 missense possibly damaging 0.89
R7806:Gpr152 UTSW 19 4143488 missense probably benign
R8315:Gpr152 UTSW 19 4143470 missense probably damaging 1.00
R8889:Gpr152 UTSW 19 4142724 missense probably damaging 1.00
Posted On2016-08-02