Incidental Mutation 'IGL03335:Gpr152'
| ID |
417009 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr152
|
| Ensembl Gene |
ENSMUSG00000044724 |
| Gene Name |
G protein-coupled receptor 152 |
| Synonyms |
LOC269053, A930009H15Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03335
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
19 |
| Chromosomal Location |
4189798-4195740 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 4193770 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Asparagine
at position 437
(T437N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094062
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000008893]
[ENSMUST00000025761]
[ENSMUST00000096338]
[ENSMUST00000123874]
|
| AlphaFold |
Q8BXS7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000008893
|
| SMART Domains |
Protein: ENSMUSP00000008893
Gene: ENSMUSG00000024835
| Domain | Start | End | E-Value | Type |
|---|
|
DUF1899
|
5 |
69 |
1.48e-37 |
SMART |
|
WD40
|
68 |
111 |
2.1e-7 |
SMART |
|
WD40
|
121 |
161 |
1.44e-5 |
SMART |
|
WD40
|
164 |
204 |
4.08e-5 |
SMART |
|
DUF1900
|
258 |
392 |
6.41e-88 |
SMART |
|
coiled coil region
|
445 |
482 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000025761
|
| SMART Domains |
Protein: ENSMUSP00000025761
Gene: ENSMUSG00000024842
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
45 |
67 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
97 |
N/A |
INTRINSIC |
|
EFh
|
129 |
157 |
1.08e-6 |
SMART |
|
Blast:EFh
|
165 |
193 |
2e-7 |
BLAST |
|
EFh
|
206 |
234 |
1.05e-4 |
SMART |
|
EFh
|
243 |
271 |
1.55e-7 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000096338
AA Change: T437N
PolyPhen 2
Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000094062
Gene: ENSMUSG00000044724
AA Change: T437N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
47 |
295 |
7e-19 |
PFAM |
|
low complexity region
|
347 |
361 |
N/A |
INTRINSIC |
|
low complexity region
|
419 |
433 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123874
|
| SMART Domains |
Protein: ENSMUSP00000118450
Gene: ENSMUSG00000024835
| Domain | Start | End | E-Value | Type |
|---|
|
DUF1899
|
5 |
69 |
1.48e-37 |
SMART |
|
WD40
|
68 |
111 |
2.1e-7 |
SMART |
|
WD40
|
121 |
161 |
1.44e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134194
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142878
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143613
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148733
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb4 |
T |
C |
5: 8,985,258 (GRCm39) |
V713A |
probably benign |
Het |
| Abtb3 |
A |
T |
10: 85,494,222 (GRCm39) |
|
probably benign |
Het |
| Actr8 |
T |
C |
14: 29,700,514 (GRCm39) |
V31A |
probably benign |
Het |
| Alcam |
A |
C |
16: 52,111,366 (GRCm39) |
Y244* |
probably null |
Het |
| Ankrd24 |
A |
G |
10: 81,482,967 (GRCm39) |
S972G |
probably benign |
Het |
| Aox1 |
T |
A |
1: 58,115,319 (GRCm39) |
V768E |
probably damaging |
Het |
| Carmil2 |
A |
G |
8: 106,423,661 (GRCm39) |
I1212V |
probably benign |
Het |
| Catsper1 |
C |
T |
19: 5,386,339 (GRCm39) |
R191C |
probably damaging |
Het |
| Cenpe |
T |
A |
3: 134,949,386 (GRCm39) |
V57D |
probably benign |
Het |
| Cpsf3 |
T |
C |
12: 21,356,888 (GRCm39) |
|
probably null |
Het |
| Cubn |
A |
G |
2: 13,365,140 (GRCm39) |
S1633P |
probably damaging |
Het |
| Dsg1c |
G |
A |
18: 20,416,754 (GRCm39) |
R885Q |
probably benign |
Het |
| Egfl6 |
C |
A |
X: 165,321,689 (GRCm39) |
G272W |
probably damaging |
Het |
| Ermard |
T |
C |
17: 15,279,668 (GRCm39) |
L486P |
probably damaging |
Het |
| F13b |
A |
T |
1: 139,450,124 (GRCm39) |
L595F |
probably damaging |
Het |
| Foxm1 |
A |
G |
6: 128,349,531 (GRCm39) |
N350S |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,881,803 (GRCm39) |
|
probably benign |
Het |
| Icmt |
T |
A |
4: 152,385,154 (GRCm39) |
Y205* |
probably null |
Het |
| Ints8 |
A |
T |
4: 11,216,460 (GRCm39) |
F844I |
probably damaging |
Het |
| Mep1a |
T |
A |
17: 43,788,064 (GRCm39) |
D664V |
possibly damaging |
Het |
| Muc4 |
T |
A |
16: 32,574,449 (GRCm39) |
N966K |
probably benign |
Het |
| Myo7b |
T |
A |
18: 32,118,073 (GRCm39) |
Q851L |
possibly damaging |
Het |
| Pdzd2 |
T |
C |
15: 12,373,850 (GRCm39) |
H2095R |
probably benign |
Het |
| Phldb1 |
A |
G |
9: 44,639,366 (GRCm39) |
L4P |
possibly damaging |
Het |
| Pkd1l2 |
G |
A |
8: 117,792,484 (GRCm39) |
T436I |
probably benign |
Het |
| Pnpla8 |
T |
A |
12: 44,329,947 (GRCm39) |
N166K |
probably benign |
Het |
| Qrfprl |
T |
C |
6: 65,430,101 (GRCm39) |
|
probably null |
Het |
| Rapgef2 |
A |
G |
3: 79,006,492 (GRCm39) |
M137T |
probably damaging |
Het |
| Rbm15b |
G |
A |
9: 106,761,538 (GRCm39) |
H877Y |
probably damaging |
Het |
| Rbm45 |
T |
C |
2: 76,206,777 (GRCm39) |
L263P |
probably damaging |
Het |
| Rprd1b |
T |
C |
2: 157,916,884 (GRCm39) |
V288A |
probably damaging |
Het |
| Tmtc3 |
C |
A |
10: 100,302,116 (GRCm39) |
V278L |
probably damaging |
Het |
| Tomm70a |
A |
G |
16: 56,970,289 (GRCm39) |
T556A |
probably damaging |
Het |
| Trpc7 |
T |
C |
13: 57,035,504 (GRCm39) |
E143G |
probably damaging |
Het |
| Trpm3 |
G |
T |
19: 22,903,435 (GRCm39) |
|
probably null |
Het |
| Ugt2b34 |
T |
C |
5: 87,054,499 (GRCm39) |
E94G |
probably benign |
Het |
| Vmn1r174 |
T |
C |
7: 23,453,937 (GRCm39) |
V201A |
probably benign |
Het |
| Zfp352 |
T |
C |
4: 90,112,583 (GRCm39) |
F241S |
probably damaging |
Het |
|
| Other mutations in Gpr152 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Gpr152
|
APN |
19 |
4,193,506 (GRCm39) |
missense |
probably benign |
|
|
IGL01400:Gpr152
|
APN |
19 |
4,193,626 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01538:Gpr152
|
APN |
19 |
4,192,951 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02288:Gpr152
|
APN |
19 |
4,193,694 (GRCm39) |
missense |
probably benign |
|
|
IGL02513:Gpr152
|
APN |
19 |
4,192,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0318:Gpr152
|
UTSW |
19 |
4,193,541 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1216:Gpr152
|
UTSW |
19 |
4,193,554 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1936:Gpr152
|
UTSW |
19 |
4,192,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2248:Gpr152
|
UTSW |
19 |
4,193,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3161:Gpr152
|
UTSW |
19 |
4,192,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4193:Gpr152
|
UTSW |
19 |
4,192,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4719:Gpr152
|
UTSW |
19 |
4,193,223 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4852:Gpr152
|
UTSW |
19 |
4,193,790 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5014:Gpr152
|
UTSW |
19 |
4,193,506 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5381:Gpr152
|
UTSW |
19 |
4,192,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5431:Gpr152
|
UTSW |
19 |
4,193,746 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5470:Gpr152
|
UTSW |
19 |
4,193,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7331:Gpr152
|
UTSW |
19 |
4,192,608 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7350:Gpr152
|
UTSW |
19 |
4,192,963 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Gpr152
|
UTSW |
19 |
4,193,487 (GRCm39) |
missense |
probably benign |
|
|
R8315:Gpr152
|
UTSW |
19 |
4,193,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8889:Gpr152
|
UTSW |
19 |
4,192,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9455:Gpr152
|
UTSW |
19 |
4,193,844 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9651:Gpr152
|
UTSW |
19 |
4,192,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9709:Gpr152
|
UTSW |
19 |
4,192,640 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9761:Gpr152
|
UTSW |
19 |
4,193,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation