Incidental Mutation 'IGL03336:Or6c203'
ID 417024
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6c203
Ensembl Gene ENSMUSG00000107662
Gene Name olfactory receptor family 6 subfamily C member 203
Synonyms MOR114-3, GA_x6K02T2PULF-10860457-10859522, Olfr772
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # IGL03336
Quality Score
Status
Chromosome 10
Chromosomal Location 129009920-129010923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129010098 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 264 (E264G)
Ref Sequence ENSEMBL: ENSMUSP00000148854 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169800] [ENSMUST00000214672]
AlphaFold Q8VGC5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122783
Predicted Effect probably benign
Transcript: ENSMUST00000169800
AA Change: E264G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000132389
Gene: ENSMUSG00000107662
AA Change: E264G

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.6e-47 PFAM
Pfam:7tm_1 38 287 1.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214672
AA Change: E264G

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik A G 15: 59,888,251 (GRCm39) V63A probably benign Het
Ankrd11 A G 8: 123,618,582 (GRCm39) S1757P probably benign Het
Atp8a1 G T 5: 67,887,150 (GRCm39) Y629* probably null Het
Cenpf T C 1: 189,384,844 (GRCm39) K2479E probably damaging Het
Clip1 G T 5: 123,791,633 (GRCm39) S179* probably null Het
Cmya5 A G 13: 93,230,013 (GRCm39) S1692P possibly damaging Het
Cyp17a1 T C 19: 46,659,474 (GRCm39) S119G probably benign Het
Fndc5 T C 4: 129,033,711 (GRCm39) F160L probably benign Het
Muc5b T C 7: 141,418,100 (GRCm39) V3682A probably damaging Het
Myh8 G T 11: 67,175,528 (GRCm39) D328Y probably damaging Het
Or10a5 T A 7: 106,635,542 (GRCm39) M60K probably damaging Het
Or4c121 T C 2: 89,024,241 (GRCm39) T46A probably benign Het
Or51f1 C T 7: 102,505,823 (GRCm39) C222Y probably benign Het
Or51k2 T C 7: 103,596,616 (GRCm39) L281P probably damaging Het
Paxbp1 T C 16: 90,831,060 (GRCm39) I439V probably benign Het
Pcdhb3 T C 18: 37,436,014 (GRCm39) V660A possibly damaging Het
Pcyt2 T C 11: 120,506,758 (GRCm39) D32G probably damaging Het
Pdzph1 A T 17: 59,281,229 (GRCm39) V351D probably benign Het
Ribc2 C T 15: 85,017,114 (GRCm39) Q51* probably null Het
Scn2a A G 2: 65,519,088 (GRCm39) E438G probably damaging Het
Slc18a3 T C 14: 32,184,785 (GRCm39) probably benign Het
Slc5a1 G A 5: 33,304,287 (GRCm39) V296I probably benign Het
Slit3 A T 11: 35,560,928 (GRCm39) T958S probably damaging Het
Spag8 C T 4: 43,652,114 (GRCm39) probably benign Het
Susd3 A C 13: 49,392,258 (GRCm39) S144R probably benign Het
Synpo2 T C 3: 122,907,828 (GRCm39) E496G possibly damaging Het
Tbcel T C 9: 42,350,427 (GRCm39) T269A probably benign Het
Tmem156 A G 5: 65,233,107 (GRCm39) Y152H probably benign Het
Tmem247 A G 17: 87,225,857 (GRCm39) E99G probably damaging Het
Tuba3b A G 6: 145,565,450 (GRCm39) D306G possibly damaging Het
Vps13c T A 9: 67,858,924 (GRCm39) D2791E possibly damaging Het
Ypel4 A G 2: 84,567,871 (GRCm39) Y98C probably damaging Het
Other mutations in Or6c203
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02512:Or6c203 APN 10 129,010,119 (GRCm39) missense possibly damaging 0.65
IGL03072:Or6c203 APN 10 129,010,358 (GRCm39) missense probably damaging 1.00
R1852:Or6c203 UTSW 10 129,010,197 (GRCm39) missense probably benign 0.00
R2496:Or6c203 UTSW 10 129,009,966 (GRCm39) missense probably benign 0.00
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6031:Or6c203 UTSW 10 129,010,224 (GRCm39) missense probably benign 0.14
R6168:Or6c203 UTSW 10 129,010,035 (GRCm39) missense probably damaging 1.00
R7454:Or6c203 UTSW 10 129,010,324 (GRCm39) missense probably damaging 1.00
R7669:Or6c203 UTSW 10 129,010,128 (GRCm39) missense probably damaging 1.00
R7905:Or6c203 UTSW 10 129,010,056 (GRCm39) missense probably damaging 0.99
R8307:Or6c203 UTSW 10 129,010,101 (GRCm39) missense probably benign 0.00
R8830:Or6c203 UTSW 10 129,010,715 (GRCm39) nonsense probably null
R9405:Or6c203 UTSW 10 129,010,165 (GRCm39) missense probably benign 0.08
Posted On 2016-08-02