Incidental Mutation 'IGL03336:Tmem156'
ID 417032
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem156
Ensembl Gene ENSMUSG00000037913
Gene Name transmembrane protein 156
Synonyms LOC243025
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL03336
Quality Score
Status
Chromosome 5
Chromosomal Location 65215558-65249524 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 65233107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 152 (Y152H)
Ref Sequence ENSEMBL: ENSMUSP00000148480 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043352] [ENSMUST00000212080] [ENSMUST00000212194] [ENSMUST00000212640]
AlphaFold A0A1D5RLR8
Predicted Effect probably benign
Transcript: ENSMUST00000043352
AA Change: Y140H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000044102
Gene: ENSMUSG00000037913
AA Change: Y140H

DomainStartEndE-ValueType
transmembrane domain 5 22 N/A INTRINSIC
Pfam:TMEM156 39 264 1.2e-111 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203664
Predicted Effect probably benign
Transcript: ENSMUST00000212080
AA Change: Y152H

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000212194
AA Change: Y117H

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000212640
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik A G 15: 59,888,251 (GRCm39) V63A probably benign Het
Ankrd11 A G 8: 123,618,582 (GRCm39) S1757P probably benign Het
Atp8a1 G T 5: 67,887,150 (GRCm39) Y629* probably null Het
Cenpf T C 1: 189,384,844 (GRCm39) K2479E probably damaging Het
Clip1 G T 5: 123,791,633 (GRCm39) S179* probably null Het
Cmya5 A G 13: 93,230,013 (GRCm39) S1692P possibly damaging Het
Cyp17a1 T C 19: 46,659,474 (GRCm39) S119G probably benign Het
Fndc5 T C 4: 129,033,711 (GRCm39) F160L probably benign Het
Muc5b T C 7: 141,418,100 (GRCm39) V3682A probably damaging Het
Myh8 G T 11: 67,175,528 (GRCm39) D328Y probably damaging Het
Or10a5 T A 7: 106,635,542 (GRCm39) M60K probably damaging Het
Or4c121 T C 2: 89,024,241 (GRCm39) T46A probably benign Het
Or51f1 C T 7: 102,505,823 (GRCm39) C222Y probably benign Het
Or51k2 T C 7: 103,596,616 (GRCm39) L281P probably damaging Het
Or6c203 T C 10: 129,010,098 (GRCm39) E264G probably benign Het
Paxbp1 T C 16: 90,831,060 (GRCm39) I439V probably benign Het
Pcdhb3 T C 18: 37,436,014 (GRCm39) V660A possibly damaging Het
Pcyt2 T C 11: 120,506,758 (GRCm39) D32G probably damaging Het
Pdzph1 A T 17: 59,281,229 (GRCm39) V351D probably benign Het
Ribc2 C T 15: 85,017,114 (GRCm39) Q51* probably null Het
Scn2a A G 2: 65,519,088 (GRCm39) E438G probably damaging Het
Slc18a3 T C 14: 32,184,785 (GRCm39) probably benign Het
Slc5a1 G A 5: 33,304,287 (GRCm39) V296I probably benign Het
Slit3 A T 11: 35,560,928 (GRCm39) T958S probably damaging Het
Spag8 C T 4: 43,652,114 (GRCm39) probably benign Het
Susd3 A C 13: 49,392,258 (GRCm39) S144R probably benign Het
Synpo2 T C 3: 122,907,828 (GRCm39) E496G possibly damaging Het
Tbcel T C 9: 42,350,427 (GRCm39) T269A probably benign Het
Tmem247 A G 17: 87,225,857 (GRCm39) E99G probably damaging Het
Tuba3b A G 6: 145,565,450 (GRCm39) D306G possibly damaging Het
Vps13c T A 9: 67,858,924 (GRCm39) D2791E possibly damaging Het
Ypel4 A G 2: 84,567,871 (GRCm39) Y98C probably damaging Het
Other mutations in Tmem156
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Tmem156 APN 5 65,231,183 (GRCm39) missense probably damaging 1.00
IGL01064:Tmem156 APN 5 65,237,327 (GRCm39) missense probably damaging 0.99
IGL01330:Tmem156 APN 5 65,237,525 (GRCm39) missense probably benign 0.17
IGL03383:Tmem156 APN 5 65,233,040 (GRCm39) missense probably damaging 0.98
R0526:Tmem156 UTSW 5 65,233,161 (GRCm39) missense probably benign 0.02
R2006:Tmem156 UTSW 5 65,237,294 (GRCm39) missense probably damaging 1.00
R4721:Tmem156 UTSW 5 65,248,870 (GRCm39) missense probably benign 0.10
R4773:Tmem156 UTSW 5 65,237,502 (GRCm39) missense probably damaging 1.00
R4810:Tmem156 UTSW 5 65,248,790 (GRCm39) intron probably benign
R4910:Tmem156 UTSW 5 65,248,805 (GRCm39) intron probably benign
R5148:Tmem156 UTSW 5 65,231,111 (GRCm39) missense probably benign 0.00
R5510:Tmem156 UTSW 5 65,232,917 (GRCm39) missense probably benign 0.02
R5809:Tmem156 UTSW 5 65,232,950 (GRCm39) missense possibly damaging 0.55
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R6033:Tmem156 UTSW 5 65,232,964 (GRCm39) missense probably benign 0.35
R7731:Tmem156 UTSW 5 65,232,905 (GRCm39) critical splice donor site probably null
R7772:Tmem156 UTSW 5 65,237,517 (GRCm39) missense probably damaging 1.00
R7788:Tmem156 UTSW 5 65,232,912 (GRCm39) missense possibly damaging 0.47
R7979:Tmem156 UTSW 5 65,237,352 (GRCm39) missense possibly damaging 0.47
R8017:Tmem156 UTSW 5 65,231,204 (GRCm39) missense probably damaging 1.00
R8132:Tmem156 UTSW 5 65,233,098 (GRCm39) missense probably benign 0.00
R8249:Tmem156 UTSW 5 65,232,969 (GRCm39) nonsense probably null
R8492:Tmem156 UTSW 5 65,222,438 (GRCm39) missense possibly damaging 0.87
R9209:Tmem156 UTSW 5 65,231,127 (GRCm39) missense probably damaging 1.00
R9287:Tmem156 UTSW 5 65,231,148 (GRCm39) missense probably damaging 1.00
R9468:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9470:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9471:Tmem156 UTSW 5 65,237,531 (GRCm39) missense probably damaging 0.99
R9696:Tmem156 UTSW 5 65,231,147 (GRCm39) missense possibly damaging 0.83
RF020:Tmem156 UTSW 5 65,248,890 (GRCm39) missense probably benign 0.34
Posted On 2016-08-02