Incidental Mutation 'IGL03339:Ficd'
ID 417160
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ficd
Ensembl Gene ENSMUSG00000053334
Gene Name FIC domain containing
Synonyms D5Ertd40e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03339
Quality Score
Status
Chromosome 5
Chromosomal Location 113873864-113878661 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 113876800 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 325 (R325L)
Ref Sequence ENSEMBL: ENSMUSP00000071719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019118] [ENSMUST00000065698] [ENSMUST00000197041]
AlphaFold Q8BIX9
Predicted Effect probably benign
Transcript: ENSMUST00000019118
SMART Domains Protein: ENSMUSP00000019118
Gene: ENSMUSG00000018974

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
low complexity region 11 33 N/A INTRINSIC
low complexity region 42 50 N/A INTRINSIC
low complexity region 65 93 N/A INTRINSIC
HAT 127 159 1.76e1 SMART
HAT 165 196 4.82e-1 SMART
HAT 202 238 1.53e-3 SMART
low complexity region 269 281 N/A INTRINSIC
HAT 325 357 1.78e-4 SMART
HAT 360 392 7.83e-1 SMART
HAT 395 431 7.56e0 SMART
HAT 488 521 7.31e-1 SMART
coiled coil region 554 619 N/A INTRINSIC
low complexity region 626 640 N/A INTRINSIC
RRM 705 778 1.87e-14 SMART
RRM 802 874 3.2e-22 SMART
Pfam:LSM_int_assoc 877 937 3.1e-28 PFAM
Pfam:Lsm_interact 944 961 2e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065698
AA Change: R325L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071719
Gene: ENSMUSG00000053334
AA Change: R325L

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
SCOP:d1elwa_ 105 180 2e-8 SMART
Pfam:Fic 284 381 1.8e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000197041
SMART Domains Protein: ENSMUSP00000143778
Gene: ENSMUSG00000018974

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
low complexity region 11 33 N/A INTRINSIC
low complexity region 42 50 N/A INTRINSIC
low complexity region 65 93 N/A INTRINSIC
HAT 127 159 1.76e1 SMART
HAT 165 196 4.82e-1 SMART
HAT 202 238 1.53e-3 SMART
low complexity region 269 281 N/A INTRINSIC
Blast:HAT 292 323 1e-5 BLAST
HAT 325 357 1.33e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A G 2: 152,284,376 (GRCm39) E323G probably damaging Het
A4gnt T C 9: 99,502,601 (GRCm39) S254P probably damaging Het
Actn4 A G 7: 28,601,407 (GRCm39) L447P probably damaging Het
Agbl2 C A 2: 90,627,907 (GRCm39) S237R probably damaging Het
Apc G A 18: 34,431,527 (GRCm39) D309N probably damaging Het
Arhgef3 A G 14: 27,123,814 (GRCm39) M492V probably damaging Het
Atp10b T A 11: 43,121,442 (GRCm39) M1035K probably null Het
Cfap69 T A 5: 5,636,436 (GRCm39) probably benign Het
Ctf1 A G 7: 127,313,166 (GRCm39) N24S probably benign Het
Cx3cr1 T A 9: 119,880,503 (GRCm39) K300* probably null Het
Ddx25 A T 9: 35,453,299 (GRCm39) Y484N probably damaging Het
Eif4g1 A G 16: 20,499,734 (GRCm39) E506G possibly damaging Het
G6pc2 A G 2: 69,051,239 (GRCm39) probably benign Het
Gm11168 C A 9: 3,004,767 (GRCm39) P103T probably benign Het
Hbb-y A T 7: 103,501,976 (GRCm39) H98Q probably damaging Het
Hmcn1 A G 1: 150,577,720 (GRCm39) S2014P probably benign Het
Hoxc5 T C 15: 102,922,568 (GRCm39) Y19H probably damaging Het
Igfbpl1 A G 4: 45,813,555 (GRCm39) probably benign Het
Ighg2c A C 12: 113,251,614 (GRCm39) V171G unknown Het
Kctd13 A G 7: 126,544,190 (GRCm39) D296G probably benign Het
Mfsd2b A C 12: 4,924,335 (GRCm39) M1R probably null Het
Nipbl A G 15: 8,380,360 (GRCm39) S811P probably benign Het
Or10al2 G A 17: 37,983,448 (GRCm39) C178Y possibly damaging Het
Or10al3 G T 17: 38,011,682 (GRCm39) M40I probably damaging Het
Or52r1 G A 7: 102,536,989 (GRCm39) R124C probably benign Het
Or5b122 T G 19: 13,563,439 (GRCm39) M257R probably damaging Het
Pcolce2 T C 9: 95,560,393 (GRCm39) probably benign Het
Pik3c2a G T 7: 116,017,256 (GRCm39) T167K possibly damaging Het
Ppp1r18 A G 17: 36,178,938 (GRCm39) D271G probably benign Het
Rnf213 T C 11: 119,333,830 (GRCm39) I3013T probably damaging Het
Rock1 A T 18: 10,097,493 (GRCm39) M765K probably benign Het
Sec16a T C 2: 26,325,945 (GRCm39) Y1244C probably benign Het
Taar7d T C 10: 23,903,204 (GRCm39) C29R possibly damaging Het
Tlcd4 C T 3: 121,022,489 (GRCm39) probably benign Het
Ttn A C 2: 76,572,264 (GRCm39) F26210V probably damaging Het
Ube2b A T 11: 51,877,534 (GRCm39) V145D probably damaging Het
Vmn1r219 T G 13: 23,347,580 (GRCm39) S256R possibly damaging Het
Other mutations in Ficd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Ficd APN 5 113,876,622 (GRCm39) missense probably damaging 1.00
IGL01774:Ficd APN 5 113,877,073 (GRCm39) missense probably damaging 0.98
IGL01899:Ficd APN 5 113,875,158 (GRCm39) missense probably benign
IGL02237:Ficd APN 5 113,876,373 (GRCm39) missense probably damaging 0.98
IGL02527:Ficd APN 5 113,875,027 (GRCm39) missense probably benign 0.04
IGL03030:Ficd APN 5 113,874,990 (GRCm39) missense probably benign
IGL03062:Ficd APN 5 113,876,314 (GRCm39) missense probably damaging 1.00
R0145:Ficd UTSW 5 113,876,880 (GRCm39) missense probably damaging 1.00
R5207:Ficd UTSW 5 113,875,072 (GRCm39) missense probably benign 0.15
R5530:Ficd UTSW 5 113,876,986 (GRCm39) missense probably damaging 1.00
R6730:Ficd UTSW 5 113,876,773 (GRCm39) missense probably damaging 1.00
R7256:Ficd UTSW 5 113,876,880 (GRCm39) missense probably damaging 1.00
R7624:Ficd UTSW 5 113,876,751 (GRCm39) missense probably benign 0.03
R7960:Ficd UTSW 5 113,877,020 (GRCm39) missense probably benign 0.00
R8757:Ficd UTSW 5 113,876,575 (GRCm39) missense probably damaging 0.99
R8759:Ficd UTSW 5 113,876,575 (GRCm39) missense probably damaging 0.99
R8870:Ficd UTSW 5 113,876,248 (GRCm39) missense probably damaging 0.98
R9224:Ficd UTSW 5 113,875,196 (GRCm39) missense probably benign
Posted On 2016-08-02