Incidental Mutation 'IGL03339:Ficd'
ID 417160
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ficd
Ensembl Gene ENSMUSG00000053334
Gene Name FIC domain containing
Synonyms D5Ertd40e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03339
Quality Score
Status
Chromosome 5
Chromosomal Location 113735803-113740600 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 113738739 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 325 (R325L)
Ref Sequence ENSEMBL: ENSMUSP00000071719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019118] [ENSMUST00000065698] [ENSMUST00000197041]
AlphaFold Q8BIX9
Predicted Effect probably benign
Transcript: ENSMUST00000019118
SMART Domains Protein: ENSMUSP00000019118
Gene: ENSMUSG00000018974

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
low complexity region 11 33 N/A INTRINSIC
low complexity region 42 50 N/A INTRINSIC
low complexity region 65 93 N/A INTRINSIC
HAT 127 159 1.76e1 SMART
HAT 165 196 4.82e-1 SMART
HAT 202 238 1.53e-3 SMART
low complexity region 269 281 N/A INTRINSIC
HAT 325 357 1.78e-4 SMART
HAT 360 392 7.83e-1 SMART
HAT 395 431 7.56e0 SMART
HAT 488 521 7.31e-1 SMART
coiled coil region 554 619 N/A INTRINSIC
low complexity region 626 640 N/A INTRINSIC
RRM 705 778 1.87e-14 SMART
RRM 802 874 3.2e-22 SMART
Pfam:LSM_int_assoc 877 937 3.1e-28 PFAM
Pfam:Lsm_interact 944 961 2e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065698
AA Change: R325L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071719
Gene: ENSMUSG00000053334
AA Change: R325L

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
SCOP:d1elwa_ 105 180 2e-8 SMART
Pfam:Fic 284 381 1.8e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000197041
SMART Domains Protein: ENSMUSP00000143778
Gene: ENSMUSG00000018974

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
low complexity region 11 33 N/A INTRINSIC
low complexity region 42 50 N/A INTRINSIC
low complexity region 65 93 N/A INTRINSIC
HAT 127 159 1.76e1 SMART
HAT 165 196 4.82e-1 SMART
HAT 202 238 1.53e-3 SMART
low complexity region 269 281 N/A INTRINSIC
Blast:HAT 292 323 1e-5 BLAST
HAT 325 357 1.33e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A G 2: 152,442,456 E323G probably damaging Het
A4gnt T C 9: 99,620,548 S254P probably damaging Het
Actn4 A G 7: 28,901,982 L447P probably damaging Het
Agbl2 C A 2: 90,797,563 S237R probably damaging Het
Apc G A 18: 34,298,474 D309N probably damaging Het
Arhgef3 A G 14: 27,401,857 M492V probably damaging Het
Atp10b T A 11: 43,230,615 M1035K probably null Het
Cfap69 T A 5: 5,586,436 probably benign Het
Ctf1 A G 7: 127,713,994 N24S probably benign Het
Cx3cr1 T A 9: 120,051,437 K300* probably null Het
Ddx25 A T 9: 35,542,003 Y484N probably damaging Het
Eif4g1 A G 16: 20,680,984 E506G possibly damaging Het
G6pc2 A G 2: 69,220,895 probably benign Het
Gm11168 C A 9: 3,004,767 P103T probably benign Het
Hbb-y A T 7: 103,852,769 H98Q probably damaging Het
Hmcn1 A G 1: 150,701,969 S2014P probably benign Het
Hoxc5 T C 15: 103,014,136 Y19H probably damaging Het
Igfbpl1 A G 4: 45,813,555 probably benign Het
Ighg2c A C 12: 113,287,994 V171G unknown Het
Kctd13 A G 7: 126,945,018 D296G probably benign Het
Mfsd2b A C 12: 4,874,335 M1R probably null Het
Nipbl A G 15: 8,350,876 S811P probably benign Het
Olfr118 G A 17: 37,672,557 C178Y possibly damaging Het
Olfr119 G T 17: 37,700,791 M40I probably damaging Het
Olfr1484 T G 19: 13,586,075 M257R probably damaging Het
Olfr569 G A 7: 102,887,782 R124C probably benign Het
Pcolce2 T C 9: 95,678,340 probably benign Het
Pik3c2a G T 7: 116,418,021 T167K possibly damaging Het
Ppp1r18 A G 17: 35,868,046 D271G probably benign Het
Rnf213 T C 11: 119,443,004 I3013T probably damaging Het
Rock1 A T 18: 10,097,493 M765K probably benign Het
Sec16a T C 2: 26,435,933 Y1244C probably benign Het
Taar7d T C 10: 24,027,306 C29R possibly damaging Het
Tmem56 C T 3: 121,228,840 probably benign Het
Ttn A C 2: 76,741,920 F26210V probably damaging Het
Ube2b A T 11: 51,986,707 V145D probably damaging Het
Vmn1r219 T G 13: 23,163,410 S256R possibly damaging Het
Other mutations in Ficd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01622:Ficd APN 5 113738561 missense probably damaging 1.00
IGL01774:Ficd APN 5 113739012 missense probably damaging 0.98
IGL01899:Ficd APN 5 113737097 missense probably benign
IGL02237:Ficd APN 5 113738312 missense probably damaging 0.98
IGL02527:Ficd APN 5 113736966 missense probably benign 0.04
IGL03030:Ficd APN 5 113736929 missense probably benign
IGL03062:Ficd APN 5 113738253 missense probably damaging 1.00
R0145:Ficd UTSW 5 113738819 missense probably damaging 1.00
R5207:Ficd UTSW 5 113737011 missense probably benign 0.15
R5530:Ficd UTSW 5 113738925 missense probably damaging 1.00
R6730:Ficd UTSW 5 113738712 missense probably damaging 1.00
R7256:Ficd UTSW 5 113738819 missense probably damaging 1.00
R7624:Ficd UTSW 5 113738690 missense probably benign 0.03
R7960:Ficd UTSW 5 113738959 missense probably benign 0.00
R8757:Ficd UTSW 5 113738514 missense probably damaging 0.99
R8759:Ficd UTSW 5 113738514 missense probably damaging 0.99
R8870:Ficd UTSW 5 113738187 missense probably damaging 0.98
R9224:Ficd UTSW 5 113737135 missense probably benign
Posted On 2016-08-02