Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03340:Sun3'

417208

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sun3

Ensembl Gene

ENSMUSG00000040985

Gene Name

Sad1 and UNC84 domain containing 3

Synonyms

Sunc1, D630047F21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL03340

Quality Score

Status

Chromosome

Chromosomal Location

9016054-9048991 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to C at 9023285 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000099973 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043377] [ENSMUST00000102909]

AlphaFold

Q5SS91

Predicted Effect

probably benign
Transcript: ENSMUST00000043377

SMART Domains

Protein: ENSMUSP00000045199
Gene: ENSMUSG00000040985

Domain	Start	End	E-Value	Type
transmembrane domain	7	29	N/A	INTRINSIC
Pfam:Sad1_UNC	182	316	3.4e-48	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000102909

SMART Domains

Protein: ENSMUSP00000099973
Gene: ENSMUSG00000040985

Domain	Start	End	E-Value	Type
Pfam:Sad1_UNC	122	256	3.2e-48	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700097O09Rik	A	G	12: 55,080,001	L26P	probably benign	Het
Aff1	A	T	5: 103,783,804	H104L	possibly damaging	Het
Apon	T	C	10: 128,254,978	I175T	probably benign	Het
C2cd6	A	C	1: 59,076,671	F168V	probably benign	Het
Cgn	C	T	3: 94,778,095		probably benign	Het
Cramp1l	G	A	17: 24,973,542	P956L	probably damaging	Het
Cyp2e1	G	A	7: 140,764,854	V78M	probably damaging	Het
Cyp4b1	G	A	4: 115,641,879	P97S	probably damaging	Het
Fads2	G	T	19: 10,091,772	P96Q	possibly damaging	Het
Fam160a2	A	G	7: 105,389,310	S241P	probably damaging	Het
Fcer2a	T	C	8: 3,688,310	D120G	possibly damaging	Het
Gm21972	G	T	1: 86,133,728	A887S	probably damaging	Het
Grk6	A	G	13: 55,453,190	D295G	probably damaging	Het
Herc2	T	A	7: 56,090,920	V270D	possibly damaging	Het
Kcnk2	T	A	1: 189,295,681	I126F	possibly damaging	Het
Kifap3	T	G	1: 163,829,149	V346G	possibly damaging	Het
Kpna1	T	A	16: 36,000,246	N20K	probably damaging	Het
Krt33b	A	G	11: 100,025,472		probably benign	Het
Krtap9-5	T	C	11: 99,948,601	C43R	possibly damaging	Het
Lars	G	A	18: 42,228,650		probably benign	Het
Lifr	T	C	15: 7,177,936	W540R	probably benign	Het
Lrp1b	A	G	2: 41,468,969	S631P	probably damaging	Het
Mbd1	G	T	18: 74,274,482	R111L	probably benign	Het
Meltf	C	T	16: 31,892,784	T576M	probably damaging	Het
Mmp20	G	A	9: 7,643,994	G228S	probably damaging	Het
Mob4	A	G	1: 55,136,708	D37G	possibly damaging	Het
Msr1	T	C	8: 39,620,007	K234E	possibly damaging	Het
Myof	A	G	19: 37,911,159	V1764A	probably damaging	Het
Naaladl1	A	G	19: 6,106,199	Y105C	possibly damaging	Het
Nisch	A	G	14: 31,173,144	V1065A	probably damaging	Het
Npas4	A	T	19: 4,985,066		probably benign	Het
Olfr1232	T	C	2: 89,325,695	T162A	possibly damaging	Het
Pdss2	A	G	10: 43,394,001	D280G	probably benign	Het
Plk3	A	G	4: 117,132,928	I182T	probably damaging	Het
Ppm1k	A	G	6: 57,510,726	W371R	probably damaging	Het
Samm50	T	C	15: 84,198,663		probably null	Het
Scaper	G	T	9: 55,602,832	T640K	possibly damaging	Het
Svep1	T	A	4: 58,111,451	K1056M	possibly damaging	Het
Tgs1	C	A	4: 3,604,813	P745Q	probably benign	Het
Tomm20l	A	T	12: 71,117,614		probably benign	Het
Usp38	A	C	8: 81,012,276	L237V	probably damaging	Het
Vmn1r210	T	C	13: 22,827,474	Y214C	probably benign	Het
Zan	G	A	5: 137,427,874	P2547S	unknown	Het

Other mutations in Sun3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01290:Sun3	APN	11	9023341	missense	possibly damaging	0.91
IGL01473:Sun3	APN	11	9029394	missense	probably benign	0.00
IGL01578:Sun3	APN	11	9029436	missense	probably damaging	0.98
R1944:Sun3	UTSW	11	9038296	missense	probably benign	0.00
R1945:Sun3	UTSW	11	9038296	missense	probably benign	0.00
R2233:Sun3	UTSW	11	9023371	nonsense	probably null
R4356:Sun3	UTSW	11	9016328	missense	probably damaging	1.00
R4784:Sun3	UTSW	11	9038266	missense	probably benign	0.00
R4785:Sun3	UTSW	11	9038266	missense	probably benign	0.00
R4975:Sun3	UTSW	11	9038311	nonsense	probably null
R5022:Sun3	UTSW	11	9038314	missense	probably damaging	0.96
R5134:Sun3	UTSW	11	9038287	missense	probably benign	0.04
R5163:Sun3	UTSW	11	9023295	missense	possibly damaging	0.89
R5358:Sun3	UTSW	11	9031496	missense	possibly damaging	0.90
R5668:Sun3	UTSW	11	9031433	critical splice donor site	probably null
R6621:Sun3	UTSW	11	9016242	missense	probably damaging	1.00
R7442:Sun3	UTSW	11	9031445	missense	possibly damaging	0.75
R8022:Sun3	UTSW	11	9023376	missense	probably damaging	1.00
R8134:Sun3	UTSW	11	9029346	missense	probably benign	0.00
R9130:Sun3	UTSW	11	9018170	missense	probably benign	0.13
R9454:Sun3	UTSW	11	9038281	missense	probably benign

Posted On

2016-08-02