Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03341:Ccl7'

417233

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ccl7

Ensembl Gene

ENSMUSG00000035373

Gene Name

C-C motif chemokine ligand 7

Synonyms

mcp3, Scya7, MCP-3, marc, fic

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

IGL03341

Quality Score

Status

Chromosome

Chromosomal Location

81936538-81938351 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 81936661 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Glycine at position 18 (S18G)

Ref Sequence

ENSEMBL: ENSMUSP00000021011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021011]

AlphaFold

Q03366

Predicted Effect

probably benign
Transcript: ENSMUST00000021011
AA Change: S18G

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000021011
Gene: ENSMUSG00000035373
AA Change: S18G

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
SCY	30	88	3.33e-24	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402F06Rik	C	T	2: 35,265,906 (GRCm39)	V255I	possibly damaging	Het
Acvrl1	T	A	15: 101,035,477 (GRCm39)	N334K	probably damaging	Het
Arhgef5	T	A	6: 43,257,585 (GRCm39)	I1284N	probably damaging	Het
Asns	C	A	6: 7,682,002 (GRCm39)	R236L	probably damaging	Het
Barx2	T	C	9: 31,770,090 (GRCm39)	E146G	probably damaging	Het
Cilp	A	T	9: 65,185,284 (GRCm39)	T460S	probably benign	Het
Cpa5	A	G	6: 30,626,290 (GRCm39)	Y217C	possibly damaging	Het
Dgkh	T	A	14: 78,832,931 (GRCm39)		probably benign	Het
Dmc1	T	C	15: 79,446,746 (GRCm39)	T276A	probably benign	Het
Fryl	G	A	5: 73,234,038 (GRCm39)	P1496S	probably benign	Het
Gstm2	T	C	3: 107,891,521 (GRCm39)	Y93C	possibly damaging	Het
Hc	A	T	2: 34,893,389 (GRCm39)	I1274N	probably damaging	Het
Htra1	A	G	7: 130,583,444 (GRCm39)	I355V	probably benign	Het
Ifi214	G	T	1: 173,354,082 (GRCm39)	T196K	possibly damaging	Het
Ms4a5	T	C	19: 11,256,742 (GRCm39)	T52A	probably benign	Het
Mtx3	T	C	13: 92,984,391 (GRCm39)	F191L	probably damaging	Het
Padi2	A	G	4: 140,654,424 (GRCm39)	M192V	probably benign	Het
Pdcl3	C	A	1: 39,034,976 (GRCm39)	Q178K	probably benign	Het
Rap1gap2	G	A	11: 74,326,540 (GRCm39)	R176W	probably damaging	Het
Ska2	A	G	11: 87,006,990 (GRCm39)	T32A	probably benign	Het
Slc6a18	G	T	13: 73,826,042 (GRCm39)	Q3K	probably benign	Het
Slc7a14	T	C	3: 31,292,919 (GRCm39)	Y122C	probably damaging	Het
Svep1	T	A	4: 58,070,308 (GRCm39)	K2493*	probably null	Het
Trpm6	T	A	19: 18,790,850 (GRCm39)	N628K	probably benign	Het
Ttc17	T	A	2: 94,205,566 (GRCm39)	N260I	probably damaging	Het
Ttc7b	T	C	12: 100,291,994 (GRCm39)	I193V	possibly damaging	Het
Ttn	T	A	2: 76,542,583 (GRCm39)	T25141S	possibly damaging	Het
Zfhx4	A	C	3: 5,476,910 (GRCm39)	Q3150P	probably damaging	Het

Other mutations in Ccl7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00540:Ccl7	APN	11	81,937,888 (GRCm39)	missense	probably damaging	1.00
IGL00819:Ccl7	APN	11	81,937,401 (GRCm39)	missense	probably benign	0.08
IGL01574:Ccl7	APN	11	81,937,451 (GRCm39)	missense	probably damaging	0.97
seoraksan	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00
R0416:Ccl7	UTSW	11	81,936,692 (GRCm39)	splice site	probably benign
R1864:Ccl7	UTSW	11	81,937,378 (GRCm39)	missense	probably benign	0.00
R6161:Ccl7	UTSW	11	81,937,412 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02