Incidental Mutation 'IGL03342:Vmn2r120'
| ID |
417256 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r120
|
| Ensembl Gene |
ENSMUSG00000090655 |
| Gene Name |
vomeronasal 2, receptor 120 |
| Synonyms |
EG224916 |
| Accession Numbers |
Genbank: NM_001104591; MGI: 3644483 |
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
IGL03342
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
57508783-57545314 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 57509372 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 661
(M661T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129296
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165781]
|
| AlphaFold |
A0A3Q4EG79 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165781
AA Change: M661T
PolyPhen 2
Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: M661T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
80 |
474 |
5.9e-42 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
7.5e-22 |
PFAM |
|
Pfam:7tm_3
|
598 |
836 |
1.3e-54 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
G |
A |
11: 110,287,691 (GRCm38) |
T1152M |
possibly damaging |
Het |
| Abcg2 |
G |
T |
6: 58,665,135 (GRCm38) |
R136I |
probably damaging |
Het |
| Acap2 |
A |
G |
16: 31,105,492 (GRCm38) |
V641A |
probably damaging |
Het |
| Afg3l2 |
A |
T |
18: 67,407,320 (GRCm38) |
D706E |
probably benign |
Het |
| Bbs1 |
A |
T |
19: 4,897,593 (GRCm38) |
L311Q |
probably damaging |
Het |
| Cacna1e |
A |
G |
1: 154,466,944 (GRCm38) |
|
probably null |
Het |
| Car2 |
A |
T |
3: 14,895,569 (GRCm38) |
D129V |
probably benign |
Het |
| Catsper2 |
T |
C |
2: 121,406,736 (GRCm38) |
I228V |
probably damaging |
Het |
| Cdhr3 |
C |
A |
12: 33,051,055 (GRCm38) |
R452M |
probably benign |
Het |
| Chrm1 |
A |
T |
19: 8,679,308 (GRCm38) |
Q459L |
probably benign |
Het |
| Cnbd1 |
C |
T |
4: 19,098,264 (GRCm38) |
|
probably benign |
Het |
| Coa7 |
A |
G |
4: 108,332,229 (GRCm38) |
D42G |
probably damaging |
Het |
| Ctsz |
T |
C |
2: 174,429,140 (GRCm38) |
Y187C |
possibly damaging |
Het |
| Cxcr6 |
C |
T |
9: 123,810,407 (GRCm38) |
Q165* |
probably null |
Het |
| Cyp3a11 |
G |
A |
5: 145,855,117 (GRCm38) |
P489S |
probably damaging |
Het |
| Cyp4f15 |
A |
T |
17: 32,697,936 (GRCm38) |
I276F |
probably damaging |
Het |
| Dsg1b |
T |
A |
18: 20,409,460 (GRCm38) |
M1008K |
probably benign |
Het |
| Dsg4 |
T |
A |
18: 20,451,823 (GRCm38) |
I198N |
probably damaging |
Het |
| Dtymk |
C |
A |
1: 93,794,819 (GRCm38) |
E87D |
probably benign |
Het |
| Dysf |
T |
A |
6: 84,190,872 (GRCm38) |
D1749E |
probably benign |
Het |
| Dzip3 |
G |
T |
16: 48,929,623 (GRCm38) |
Q1050K |
probably damaging |
Het |
| Echs1 |
C |
T |
7: 140,110,113 (GRCm38) |
|
probably benign |
Het |
| Enc1 |
T |
A |
13: 97,246,470 (GRCm38) |
I496N |
possibly damaging |
Het |
| Epc2 |
A |
T |
2: 49,536,646 (GRCm38) |
Y139F |
probably benign |
Het |
| Exo1 |
A |
T |
1: 175,892,127 (GRCm38) |
N246I |
probably benign |
Het |
| Flg2 |
A |
G |
3: 93,201,235 (GRCm38) |
K190R |
probably damaging |
Het |
| Gm5424 |
A |
T |
10: 62,072,192 (GRCm38) |
|
noncoding transcript |
Het |
| Gpbp1l1 |
A |
C |
4: 116,574,543 (GRCm38) |
T133P |
probably benign |
Het |
| Gpr155 |
A |
G |
2: 73,349,678 (GRCm38) |
F146S |
probably damaging |
Het |
| Grm1 |
T |
A |
10: 11,079,971 (GRCm38) |
I190L |
probably benign |
Het |
| Hif3a |
C |
T |
7: 17,041,122 (GRCm38) |
R515H |
possibly damaging |
Het |
| Kdm5b |
G |
A |
1: 134,602,576 (GRCm38) |
D442N |
probably benign |
Het |
| Manba |
A |
T |
3: 135,517,987 (GRCm38) |
I212F |
possibly damaging |
Het |
| Map3k13 |
A |
G |
16: 21,892,231 (GRCm38) |
E88G |
possibly damaging |
Het |
| Mapk7 |
A |
G |
11: 61,491,390 (GRCm38) |
L163P |
probably damaging |
Het |
| Med1 |
A |
T |
11: 98,189,180 (GRCm38) |
|
probably null |
Het |
| Mtrf1 |
T |
A |
14: 79,415,872 (GRCm38) |
|
probably null |
Het |
| Mtrf1 |
C |
T |
14: 79,415,871 (GRCm38) |
|
probably benign |
Het |
| Mtrf1 |
A |
G |
14: 79,415,980 (GRCm38) |
D365G |
possibly damaging |
Het |
| Myadm |
C |
T |
7: 3,296,887 (GRCm38) |
T55I |
possibly damaging |
Het |
| Nlgn1 |
A |
T |
3: 26,133,262 (GRCm38) |
I158N |
probably damaging |
Het |
| Nlrc4 |
A |
G |
17: 74,445,318 (GRCm38) |
L690P |
probably damaging |
Het |
| Nlrp1a |
A |
T |
11: 71,122,791 (GRCm38) |
D544E |
probably benign |
Het |
| Nlrp2 |
A |
T |
7: 5,317,483 (GRCm38) |
L20Q |
probably damaging |
Het |
| Olfr1053 |
A |
T |
2: 86,315,235 (GRCm38) |
I17N |
possibly damaging |
Het |
| Olfr1504 |
A |
G |
19: 13,887,437 (GRCm38) |
Y258H |
probably damaging |
Het |
| Olfr390 |
T |
A |
11: 73,787,483 (GRCm38) |
S182T |
probably benign |
Het |
| Padi3 |
G |
A |
4: 140,810,598 (GRCm38) |
Q4* |
probably null |
Het |
| Pfkl |
A |
T |
10: 78,005,475 (GRCm38) |
I13K |
possibly damaging |
Het |
| Pinx1 |
A |
G |
14: 63,919,569 (GRCm38) |
D315G |
probably benign |
Het |
| Prickle3 |
A |
G |
X: 7,663,496 (GRCm38) |
D47G |
probably benign |
Het |
| Psmd10 |
A |
T |
X: 140,956,654 (GRCm38) |
V5E |
probably damaging |
Het |
| Rasgrf2 |
C |
A |
13: 91,987,979 (GRCm38) |
V605F |
probably damaging |
Het |
| Smarca1 |
G |
T |
X: 47,892,269 (GRCm38) |
A84D |
probably damaging |
Het |
| Sp2 |
A |
G |
11: 96,961,762 (GRCm38) |
V112A |
probably damaging |
Het |
| Srgap3 |
G |
A |
6: 112,775,687 (GRCm38) |
R279C |
probably damaging |
Het |
| Ssfa2 |
G |
A |
2: 79,660,452 (GRCm38) |
M971I |
probably damaging |
Het |
| Trav21-dv12 |
T |
C |
14: 53,876,044 (GRCm38) |
L10P |
unknown |
Het |
| Vmn1r236 |
A |
T |
17: 21,286,974 (GRCm38) |
H118L |
probably benign |
Het |
| Vmn2r17 |
A |
T |
5: 109,427,916 (GRCm38) |
I218F |
probably damaging |
Het |
| Vmn2r41 |
G |
T |
7: 8,138,683 (GRCm38) |
A594D |
probably damaging |
Het |
| Zc2hc1a |
A |
G |
3: 7,524,223 (GRCm38) |
E103G |
possibly damaging |
Het |
| Zfp62 |
G |
T |
11: 49,215,471 (GRCm38) |
G130* |
probably null |
Het |
|
| Other mutations in Vmn2r120 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r120
|
APN |
17 |
57,525,732 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
IGL01346:Vmn2r120
|
APN |
17 |
57,545,232 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01996:Vmn2r120
|
APN |
17 |
57,525,222 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02503:Vmn2r120
|
APN |
17 |
57,509,385 (GRCm38) |
missense |
probably benign |
0.40 |
|
IGL02582:Vmn2r120
|
APN |
17 |
57,524,724 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02747:Vmn2r120
|
APN |
17 |
57,524,719 (GRCm38) |
missense |
probably benign |
0.19 |
|
IGL02896:Vmn2r120
|
APN |
17 |
57,509,008 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03139:Vmn2r120
|
APN |
17 |
57,524,742 (GRCm38) |
missense |
probably benign |
0.39 |
|
A4554:Vmn2r120
|
UTSW |
17 |
57,525,715 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0207:Vmn2r120
|
UTSW |
17 |
57,525,052 (GRCm38) |
missense |
probably benign |
0.17 |
|
R0472:Vmn2r120
|
UTSW |
17 |
57,524,518 (GRCm38) |
missense |
probably benign |
0.03 |
|
R0517:Vmn2r120
|
UTSW |
17 |
57,508,949 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1109:Vmn2r120
|
UTSW |
17 |
57,525,829 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1316:Vmn2r120
|
UTSW |
17 |
57,525,939 (GRCm38) |
missense |
probably benign |
0.28 |
|
R1543:Vmn2r120
|
UTSW |
17 |
57,522,374 (GRCm38) |
missense |
probably benign |
0.09 |
|
R1795:Vmn2r120
|
UTSW |
17 |
57,525,038 (GRCm38) |
missense |
probably benign |
0.35 |
|
R1850:Vmn2r120
|
UTSW |
17 |
57,525,826 (GRCm38) |
missense |
probably benign |
0.19 |
|
R1920:Vmn2r120
|
UTSW |
17 |
57,524,839 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1921:Vmn2r120
|
UTSW |
17 |
57,524,839 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1922:Vmn2r120
|
UTSW |
17 |
57,524,839 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2063:Vmn2r120
|
UTSW |
17 |
57,524,553 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R2064:Vmn2r120
|
UTSW |
17 |
57,524,553 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R2065:Vmn2r120
|
UTSW |
17 |
57,524,553 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R2067:Vmn2r120
|
UTSW |
17 |
57,524,553 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R2286:Vmn2r120
|
UTSW |
17 |
57,508,958 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2291:Vmn2r120
|
UTSW |
17 |
57,509,479 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3416:Vmn2r120
|
UTSW |
17 |
57,509,241 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R3874:Vmn2r120
|
UTSW |
17 |
57,524,954 (GRCm38) |
missense |
probably benign |
0.40 |
|
R4023:Vmn2r120
|
UTSW |
17 |
57,536,718 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4024:Vmn2r120
|
UTSW |
17 |
57,536,718 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4348:Vmn2r120
|
UTSW |
17 |
57,522,466 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R4409:Vmn2r120
|
UTSW |
17 |
57,509,477 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4610:Vmn2r120
|
UTSW |
17 |
57,509,120 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4771:Vmn2r120
|
UTSW |
17 |
57,524,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4786:Vmn2r120
|
UTSW |
17 |
57,522,048 (GRCm38) |
missense |
probably benign |
0.14 |
|
R4927:Vmn2r120
|
UTSW |
17 |
57,509,125 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5285:Vmn2r120
|
UTSW |
17 |
57,536,703 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5566:Vmn2r120
|
UTSW |
17 |
57,545,290 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R5578:Vmn2r120
|
UTSW |
17 |
57,522,514 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5643:Vmn2r120
|
UTSW |
17 |
57,524,977 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5644:Vmn2r120
|
UTSW |
17 |
57,524,977 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5781:Vmn2r120
|
UTSW |
17 |
57,524,938 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6084:Vmn2r120
|
UTSW |
17 |
57,525,721 (GRCm38) |
missense |
probably benign |
0.15 |
|
R6120:Vmn2r120
|
UTSW |
17 |
57,525,973 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6160:Vmn2r120
|
UTSW |
17 |
57,509,418 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6248:Vmn2r120
|
UTSW |
17 |
57,545,287 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6256:Vmn2r120
|
UTSW |
17 |
57,524,700 (GRCm38) |
nonsense |
probably null |
|
|
R6730:Vmn2r120
|
UTSW |
17 |
57,525,012 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6821:Vmn2r120
|
UTSW |
17 |
57,536,659 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6868:Vmn2r120
|
UTSW |
17 |
57,545,218 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6880:Vmn2r120
|
UTSW |
17 |
57,509,187 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6986:Vmn2r120
|
UTSW |
17 |
57,509,340 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7276:Vmn2r120
|
UTSW |
17 |
57,524,881 (GRCm38) |
missense |
probably benign |
0.11 |
|
R7373:Vmn2r120
|
UTSW |
17 |
57,509,406 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7653:Vmn2r120
|
UTSW |
17 |
57,509,258 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7667:Vmn2r120
|
UTSW |
17 |
57,536,657 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7775:Vmn2r120
|
UTSW |
17 |
57,525,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7778:Vmn2r120
|
UTSW |
17 |
57,525,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7797:Vmn2r120
|
UTSW |
17 |
57,508,874 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7824:Vmn2r120
|
UTSW |
17 |
57,525,942 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7902:Vmn2r120
|
UTSW |
17 |
57,509,244 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R7922:Vmn2r120
|
UTSW |
17 |
57,524,683 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8508:Vmn2r120
|
UTSW |
17 |
57,525,843 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8847:Vmn2r120
|
UTSW |
17 |
57,509,217 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8882:Vmn2r120
|
UTSW |
17 |
57,545,229 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9134:Vmn2r120
|
UTSW |
17 |
57,525,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9161:Vmn2r120
|
UTSW |
17 |
57,524,864 (GRCm38) |
missense |
|
|
|
R9336:Vmn2r120
|
UTSW |
17 |
57,525,201 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
RF005:Vmn2r120
|
UTSW |
17 |
57,521,991 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
Z1177:Vmn2r120
|
UTSW |
17 |
57,509,245 (GRCm38) |
missense |
probably benign |
0.00 |
|
Z1188:Vmn2r120
|
UTSW |
17 |
57,522,436 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation