Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03343:Dusp27'

417321

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dusp27

Ensembl Gene

ENSMUSG00000026564

Gene Name

dual specificity phosphatase 27 (putative)

Synonyms

C130085G02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03343

Quality Score

Status

Chromosome

Chromosomal Location

166098148-166127922 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 166099448 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glycine at position 865 (D865G)

Ref Sequence

ENSEMBL: ENSMUSP00000141564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085992] [ENSMUST00000192369]

AlphaFold

Q148W8

Predicted Effect

probably benign
Transcript: ENSMUST00000085992
AA Change: D865G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000083155
Gene: ENSMUSG00000026564
AA Change: D865G

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000192369
AA Change: D865G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000141564
Gene: ENSMUSG00000026564
AA Change: D865G

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430419D17Rik	T	A	7: 131,246,691	I858N	probably damaging	Het
Adamts17	A	G	7: 67,075,316	H795R	probably damaging	Het
Adgrl2	A	T	3: 148,859,380	I188K	probably damaging	Het
Adgrv1	A	G	13: 81,283,388	Y5974H	probably damaging	Het
Angpt4	A	G	2: 151,936,703	T336A	probably damaging	Het
Arhgap30	C	A	1: 171,409,094	T1012N	probably damaging	Het
Asl	A	T	5: 130,012,067	Y178N	probably damaging	Het
Brd1	C	A	15: 88,707,251	L714F	possibly damaging	Het
Ccdc129	T	G	6: 55,968,584	D763E	probably damaging	Het
Ccdc47	A	G	11: 106,204,962	S303P	probably damaging	Het
Cdk16	A	G	X: 20,695,759	K264E	probably damaging	Het
Cenpc1	A	T	5: 86,016,322	F813L	probably damaging	Het
Cfp	A	C	X: 20,928,009	F291C	possibly damaging	Het
Chordc1	T	G	9: 18,312,466	F276V	probably damaging	Het
Clic4	C	T	4: 135,218,578	R176H	possibly damaging	Het
Fcer1a	T	G	1: 173,225,473	N52T	possibly damaging	Het
Fndc7	A	T	3: 108,867,308	C545S	probably damaging	Het
Frem2	T	C	3: 53,652,253	D1611G	probably damaging	Het
Fryl	G	A	5: 73,076,695	P1496S	probably benign	Het
Gga3	A	T	11: 115,592,486	N82K	probably damaging	Het
Gm43638	G	A	5: 87,460,625	P452S	possibly damaging	Het
Gpn1	T	C	5: 31,504,965	S244P	probably damaging	Het
Hspa12a	T	C	19: 58,799,396	S665G	probably benign	Het
Htt	A	G	5: 34,826,041	I995V	probably benign	Het
Iars	A	T	13: 49,724,747	I916L	probably benign	Het
Ice1	C	A	13: 70,602,929	L1679F	probably damaging	Het
Inpp1	A	T	1: 52,799,327	D54E	probably damaging	Het
Irf2bpl	T	C	12: 86,882,939	E320G	possibly damaging	Het
Kcnn2	T	C	18: 45,676,959	V421A	probably damaging	Het
Micu2	A	G	14: 57,917,311	V419A	probably benign	Het
Nek9	C	T	12: 85,303,609	C897Y	probably damaging	Het
Ofcc1	A	C	13: 40,072,664	H797Q	probably benign	Het
Olfr1024	T	C	2: 85,904,941	T38A	probably benign	Het
Olfr109	G	A	17: 37,466,409	D68N	probably damaging	Het
Olfr1388	C	A	11: 49,444,243	H131N	probably damaging	Het
Olfr822	T	G	10: 130,075,256	L282R	probably damaging	Het
Pakap	C	T	4: 57,688,502	T115M	probably damaging	Het
Papss1	G	A	3: 131,583,189	G151S	probably benign	Het
Plxnb1	A	G	9: 109,114,712	T1956A	probably damaging	Het
Pomt1	A	G	2: 32,253,712		probably benign	Het
Ppfibp2	T	A	7: 107,737,919	Y570*	probably null	Het
Ppp1r9a	A	G	6: 5,046,015	E493G	probably damaging	Het
Ptk2b	A	G	14: 66,169,421	F621L	probably benign	Het
Ptpn13	G	T	5: 103,554,950	D1261Y	possibly damaging	Het
Ptprd	C	T	4: 76,059,729	G181D	probably damaging	Het
Rabgap1l	T	C	1: 160,443,283	T645A	probably benign	Het
Slc2a7	T	C	4: 150,168,340	I479T	probably damaging	Het
Smc3	A	G	19: 53,613,842	N40S	probably damaging	Het
Spata31	A	T	13: 64,919,773	D83V	probably benign	Het
Sptb	C	T	12: 76,583,556		probably benign	Het
Ssc4d	A	T	5: 135,961,174	C493*	probably null	Het
Ubr2	C	A	17: 46,951,918	V1256L	probably benign	Het
Ubr3	T	C	2: 69,973,146		probably benign	Het
Vmn2r105	C	T	17: 20,226,369	W456*	probably null	Het
Vmn2r24	T	A	6: 123,816,111	I799N	probably damaging	Het
Vps13b	G	A	15: 35,917,170	G3720D	possibly damaging	Het

Other mutations in Dusp27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00706:Dusp27	APN	1	166100552	missense	probably benign	0.00
IGL00973:Dusp27	APN	1	166099458	missense	probably benign
IGL01331:Dusp27	APN	1	166108180	missense	probably damaging	1.00
IGL01466:Dusp27	APN	1	166100504	missense	probably damaging	1.00
IGL01572:Dusp27	APN	1	166100372	missense	probably benign	0.18
IGL01906:Dusp27	APN	1	166099523	missense	probably damaging	1.00
IGL01974:Dusp27	APN	1	166100536	nonsense	probably null
IGL02112:Dusp27	APN	1	166099671	nonsense	probably null
IGL02805:Dusp27	APN	1	166099061	missense	probably damaging	1.00
R0116:Dusp27	UTSW	1	166099701	missense	probably benign	0.19
R0367:Dusp27	UTSW	1	166100763	missense	probably benign	0.05
R0499:Dusp27	UTSW	1	166099101	missense	probably benign	0.00
R0542:Dusp27	UTSW	1	166101284	missense	possibly damaging	0.90
R1312:Dusp27	UTSW	1	166099291	missense	possibly damaging	0.46
R1572:Dusp27	UTSW	1	166099455	missense	possibly damaging	0.68
R1598:Dusp27	UTSW	1	166110259	missense	probably benign	0.10
R1858:Dusp27	UTSW	1	166100846	missense	possibly damaging	0.87
R2021:Dusp27	UTSW	1	166100823	missense	probably benign	0.00
R2970:Dusp27	UTSW	1	166099229	missense	probably benign	0.04
R3727:Dusp27	UTSW	1	166099506	missense	probably damaging	1.00
R4041:Dusp27	UTSW	1	166100111	missense	probably benign	0.01
R4245:Dusp27	UTSW	1	166101116	missense	probably damaging	1.00
R4955:Dusp27	UTSW	1	166108092	missense	probably damaging	1.00
R4967:Dusp27	UTSW	1	166127106	missense	probably damaging	1.00
R5040:Dusp27	UTSW	1	166100345	missense	probably benign	0.17
R5342:Dusp27	UTSW	1	166110250	missense	probably benign	0.01
R5467:Dusp27	UTSW	1	166112030	critical splice donor site	probably null
R5742:Dusp27	UTSW	1	166099454	missense	probably benign	0.00
R6222:Dusp27	UTSW	1	166098645	missense	probably benign	0.26
R6239:Dusp27	UTSW	1	166098819	missense	probably damaging	1.00
R6531:Dusp27	UTSW	1	166110046	splice site	probably null
R6586:Dusp27	UTSW	1	166100885	missense	possibly damaging	0.79
R6958:Dusp27	UTSW	1	166107996	missense	probably damaging	1.00
R7006:Dusp27	UTSW	1	166099094	missense	probably benign
R7111:Dusp27	UTSW	1	166127154	missense	possibly damaging	0.66
R7310:Dusp27	UTSW	1	166098731	missense	possibly damaging	0.46
R7312:Dusp27	UTSW	1	166127107	missense	probably damaging	0.99
R7378:Dusp27	UTSW	1	166112063	nonsense	probably null
R7398:Dusp27	UTSW	1	166100475	missense	probably damaging	1.00
R7442:Dusp27	UTSW	1	166101015	missense	probably benign	0.01
R7569:Dusp27	UTSW	1	166108035	missense	probably damaging	1.00
R7920:Dusp27	UTSW	1	166099896	missense	possibly damaging	0.72
R7954:Dusp27	UTSW	1	166099280	missense	probably benign	0.05
R7972:Dusp27	UTSW	1	166099139	missense	probably damaging	1.00
R8186:Dusp27	UTSW	1	166100079	missense	probably damaging	1.00
R8354:Dusp27	UTSW	1	166108133	missense	probably damaging	1.00
R8454:Dusp27	UTSW	1	166108133	missense	probably damaging	1.00
R8535:Dusp27	UTSW	1	166101161	missense	probably benign	0.01
R9419:Dusp27	UTSW	1	166100186	missense	probably damaging	1.00
R9493:Dusp27	UTSW	1	166098841	missense	probably damaging	1.00
R9694:Dusp27	UTSW	1	166101085	missense	probably damaging	1.00
Z1088:Dusp27	UTSW	1	166099283	missense	probably damaging	1.00

Posted On

2016-08-02