Incidental Mutation 'IGL03344:Tmem202'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem202
Ensembl Gene ENSMUSG00000049526
Gene Nametransmembrane protein 202
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL03344
Quality Score
Chromosomal Location59518685-59539847 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59519068 bp
Amino Acid Change Threonine to Alanine at position 272 (T272A)
Ref Sequence ENSEMBL: ENSMUSP00000053782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055345]
Predicted Effect possibly damaging
Transcript: ENSMUST00000055345
AA Change: T272A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000053782
Gene: ENSMUSG00000049526
AA Change: T272A

Pfam:PMP22_Claudin 50 206 2.2e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214580
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A T 8: 79,248,376 I26N probably damaging Het
2410089E03Rik C A 15: 8,187,458 P720Q possibly damaging Het
AI314180 A C 4: 58,828,538 V965G probably damaging Het
Armc4 C A 18: 7,129,434 G915* probably null Het
Atxn7l1 A G 12: 33,326,066 N47D probably damaging Het
BC003331 T C 1: 150,363,544 E386G probably damaging Het
Cer1 A T 4: 82,884,825 W87R probably damaging Het
Chrna2 A G 14: 66,150,966 K477E probably damaging Het
Chtf8 G A 8: 106,886,272 P12S probably damaging Het
Deaf1 A T 7: 141,297,548 H555Q probably benign Het
Dopey1 T G 9: 86,536,144 I1975M probably damaging Het
Fsd2 C A 7: 81,559,909 V62L probably benign Het
Fxyd6 T G 9: 45,392,250 L81R probably benign Het
Htt T A 5: 34,879,828 S2086T probably benign Het
Htt T A 5: 34,907,466 S3008T probably benign Het
Mybbp1a G T 11: 72,445,202 R447L probably damaging Het
Nup210 A G 6: 91,021,429 V792A possibly damaging Het
Olfr342 T C 2: 36,528,128 S239P probably damaging Het
Olfr392 T A 11: 73,814,177 I302L probably benign Het
Prokr1 T C 6: 87,588,500 D121G possibly damaging Het
Puf60 A G 15: 76,070,380 V548A possibly damaging Het
Serpina3c T C 12: 104,147,264 I408V probably benign Het
Ska2 A G 11: 87,109,313 probably benign Het
Slc4a9 T A 18: 36,535,601 Y745N probably damaging Het
Speer4f1 A G 5: 17,480,334 E209G possibly damaging Het
Spg20 T C 3: 55,121,685 M299T probably benign Het
Vegfc T A 8: 54,157,151 I114N possibly damaging Het
Vmn1r61 T A 7: 5,610,494 T274S possibly damaging Het
Zfpm2 A G 15: 41,102,774 N753S probably benign Het
Zmym6 A G 4: 127,120,521 T624A probably damaging Het
Other mutations in Tmem202
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0011:Tmem202 UTSW 9 59524801 missense probably benign 0.00
R0011:Tmem202 UTSW 9 59524801 missense probably benign 0.00
R0711:Tmem202 UTSW 9 59525372 missense probably damaging 0.99
R1690:Tmem202 UTSW 9 59519108 missense possibly damaging 0.93
R2127:Tmem202 UTSW 9 59520200 missense probably benign 0.41
R4747:Tmem202 UTSW 9 59519194 missense possibly damaging 0.47
R4998:Tmem202 UTSW 9 59524846 missense probably damaging 0.99
R6916:Tmem202 UTSW 9 59525474 start gained probably benign
R6929:Tmem202 UTSW 9 59519221 missense probably benign 0.20
Posted On2016-08-02