Incidental Mutation 'IGL03344:Tmem202'
ID417368
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem202
Ensembl Gene ENSMUSG00000049526
Gene Nametransmembrane protein 202
Synonyms4930425N13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL03344
Quality Score
Status
Chromosome9
Chromosomal Location59518685-59539847 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 59519068 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 272 (T272A)
Ref Sequence ENSEMBL: ENSMUSP00000053782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055345]
Predicted Effect possibly damaging
Transcript: ENSMUST00000055345
AA Change: T272A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000053782
Gene: ENSMUSG00000049526
AA Change: T272A

DomainStartEndE-ValueType
Pfam:PMP22_Claudin 50 206 2.2e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214580
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A T 8: 79,248,376 I26N probably damaging Het
2410089E03Rik C A 15: 8,187,458 P720Q possibly damaging Het
AI314180 A C 4: 58,828,538 V965G probably damaging Het
Armc4 C A 18: 7,129,434 G915* probably null Het
Atxn7l1 A G 12: 33,326,066 N47D probably damaging Het
BC003331 T C 1: 150,363,544 E386G probably damaging Het
Cer1 A T 4: 82,884,825 W87R probably damaging Het
Chrna2 A G 14: 66,150,966 K477E probably damaging Het
Chtf8 G A 8: 106,886,272 P12S probably damaging Het
Deaf1 A T 7: 141,297,548 H555Q probably benign Het
Dopey1 T G 9: 86,536,144 I1975M probably damaging Het
Fsd2 C A 7: 81,559,909 V62L probably benign Het
Fxyd6 T G 9: 45,392,250 L81R probably benign Het
Htt T A 5: 34,879,828 S2086T probably benign Het
Htt T A 5: 34,907,466 S3008T probably benign Het
Mybbp1a G T 11: 72,445,202 R447L probably damaging Het
Nup210 A G 6: 91,021,429 V792A possibly damaging Het
Olfr342 T C 2: 36,528,128 S239P probably damaging Het
Olfr392 T A 11: 73,814,177 I302L probably benign Het
Prokr1 T C 6: 87,588,500 D121G possibly damaging Het
Puf60 A G 15: 76,070,380 V548A possibly damaging Het
Serpina3c T C 12: 104,147,264 I408V probably benign Het
Ska2 A G 11: 87,109,313 probably benign Het
Slc4a9 T A 18: 36,535,601 Y745N probably damaging Het
Speer4f1 A G 5: 17,480,334 E209G possibly damaging Het
Spg20 T C 3: 55,121,685 M299T probably benign Het
Vegfc T A 8: 54,157,151 I114N possibly damaging Het
Vmn1r61 T A 7: 5,610,494 T274S possibly damaging Het
Zfpm2 A G 15: 41,102,774 N753S probably benign Het
Zmym6 A G 4: 127,120,521 T624A probably damaging Het
Other mutations in Tmem202
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0011:Tmem202 UTSW 9 59524801 missense probably benign 0.00
R0011:Tmem202 UTSW 9 59524801 missense probably benign 0.00
R0711:Tmem202 UTSW 9 59525372 missense probably damaging 0.99
R1690:Tmem202 UTSW 9 59519108 missense possibly damaging 0.93
R2127:Tmem202 UTSW 9 59520200 missense probably benign 0.41
R4747:Tmem202 UTSW 9 59519194 missense possibly damaging 0.47
R4998:Tmem202 UTSW 9 59524846 missense probably damaging 0.99
R6916:Tmem202 UTSW 9 59525474 start gained probably benign
R6929:Tmem202 UTSW 9 59519221 missense probably benign 0.20
Posted On2016-08-02