Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03346:Vmn2r59'

417434

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r59

Ensembl Gene

ENSMUSG00000092032

Gene Name

vomeronasal 2, receptor 59

Synonyms

EG628444

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL03346

Quality Score

Status

Chromosome

Chromosomal Location

42011792-42058981 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 42043829 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 449 (H449L)

Ref Sequence

ENSEMBL: ENSMUSP00000131856 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168489]

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000121359

Predicted Effect

probably benign
Transcript: ENSMUST00000168489
AA Change: H449L

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: H449L

Domain	Start	End	E-Value	Type
signal peptide	1	17	N/A	INTRINSIC
Pfam:ANF_receptor	77	471	1.8e-44	PFAM
Pfam:NCD3G	514	567	4.3e-23	PFAM
Pfam:7tm_3	600	835	5.4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp13a5	C	T	16: 29,314,604	V410M	probably benign	Het
Cdkn2aip	G	T	8: 47,713,618	D51E	probably benign	Het
Chd6	A	G	2: 160,960,362	V2184A	probably benign	Het
Clcn1	C	T	6: 42,311,219	T797I	probably benign	Het
Cldn23	G	A	8: 35,825,440		probably benign	Het
Cntnap4	A	G	8: 112,773,576	D500G	probably benign	Het
Cog5	A	T	12: 31,894,038	I641F	possibly damaging	Het
Cr2	A	T	1: 195,169,759	V94E	probably damaging	Het
Creg2	T	G	1: 39,650,747	D65A	probably damaging	Het
Dennd4a	A	G	9: 64,888,526	R711G	possibly damaging	Het
Efr3b	A	G	12: 3,984,648	V58A	probably damaging	Het
Fbxo3	A	G	2: 104,050,294	T250A	probably damaging	Het
Fzr1	T	C	10: 81,369,184	T300A	probably benign	Het
Gabrg1	A	T	5: 70,778,131	Y227N	possibly damaging	Het
Gins3	A	G	8: 95,643,275	I197V	probably benign	Het
Gm17079	T	C	14: 51,692,963	T142A	possibly damaging	Het
Gm8909	C	A	17: 36,168,109	D83Y	probably damaging	Het
Gna15	T	C	10: 81,503,045	Y320C	probably damaging	Het
Hibch	G	A	1: 52,920,380		probably benign	Het
Kif5b	G	A	18: 6,222,767	R355W	probably damaging	Het
Klf1	T	C	8: 84,902,932	S129P	probably benign	Het
Lyl1	C	T	8: 84,702,671	P3L	possibly damaging	Het
Nat8f5	A	G	6: 85,817,658	S107P	probably damaging	Het
Olfr331	A	G	11: 58,501,755	L267P	possibly damaging	Het
Olfr938	T	A	9: 39,077,962	Q261L	probably damaging	Het
Olfr938	C	A	9: 39,077,961	Q261H	probably benign	Het
Pcdhb18	G	A	18: 37,489,621	M1I	probably null	Het
Plcb3	A	G	19: 6,955,052	F1080L	probably benign	Het
Polr2g	T	C	19: 8,798,305	H14R	probably damaging	Het
Rp1l1	A	G	14: 64,029,440	D825G	probably benign	Het
Scn3a	G	A	2: 65,536,672	A2V	probably damaging	Het
Slc25a54	T	C	3: 109,085,730		probably benign	Het
Smad9	C	A	3: 54,789,215	Q234K	probably benign	Het
Tie1	T	C	4: 118,472,828	Y1066C	probably damaging	Het
Traf1	T	C	2: 34,948,472	E118G	probably benign	Het
Ttc21b	T	C	2: 66,237,848	D278G	possibly damaging	Het
Uaca	C	A	9: 60,854,318	T204K	probably damaging	Het
Utrn	A	T	10: 12,525,352	Y154N	probably benign	Het
Virma	A	G	4: 11,518,984	T694A	probably benign	Het
Vmn2r50	T	C	7: 10,046,002	D500G	probably damaging	Het

Other mutations in Vmn2r59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Vmn2r59	APN	7	42012064	missense	possibly damaging	0.91
IGL01432:Vmn2r59	APN	7	42012559	missense	possibly damaging	0.82
IGL02119:Vmn2r59	APN	7	42046169	missense	probably benign	0.36
IGL02216:Vmn2r59	APN	7	42012393	missense	probably damaging	1.00
IGL02327:Vmn2r59	APN	7	42012231	missense	probably benign
IGL03411:Vmn2r59	APN	7	42058916	missense	probably benign	0.43
IGL03412:Vmn2r59	APN	7	42012438	missense	probably benign
PIT4366001:Vmn2r59	UTSW	7	42045781	missense	possibly damaging	0.91
R0068:Vmn2r59	UTSW	7	42046301	missense	probably damaging	0.99
R0094:Vmn2r59	UTSW	7	42012298	missense	probably benign	0.07
R0179:Vmn2r59	UTSW	7	42047008	nonsense	probably null
R0370:Vmn2r59	UTSW	7	42012726	missense	probably benign	0.23
R0412:Vmn2r59	UTSW	7	42046492	splice site	probably benign
R0465:Vmn2r59	UTSW	7	42046908	missense	probably benign
R0487:Vmn2r59	UTSW	7	42047104	nonsense	probably null
R0576:Vmn2r59	UTSW	7	42047105	missense	probably benign	0.01
R0632:Vmn2r59	UTSW	7	42058884	missense	probably damaging	1.00
R1356:Vmn2r59	UTSW	7	42011794	makesense	probably null
R1387:Vmn2r59	UTSW	7	42046097	missense	probably damaging	1.00
R1388:Vmn2r59	UTSW	7	42045709	missense	probably benign	0.01
R1435:Vmn2r59	UTSW	7	42046205	missense	possibly damaging	0.50
R1750:Vmn2r59	UTSW	7	42045827	missense	possibly damaging	0.50
R2020:Vmn2r59	UTSW	7	42043779	missense	probably damaging	1.00
R2249:Vmn2r59	UTSW	7	42058902	missense	probably benign	0.00
R2256:Vmn2r59	UTSW	7	42012245	nonsense	probably null
R2257:Vmn2r59	UTSW	7	42012245	nonsense	probably null
R2441:Vmn2r59	UTSW	7	42046146	missense	probably benign	0.00
R2511:Vmn2r59	UTSW	7	42043766	missense	probably damaging	1.00
R2860:Vmn2r59	UTSW	7	42047003	missense	possibly damaging	0.79
R2861:Vmn2r59	UTSW	7	42047003	missense	possibly damaging	0.79
R3690:Vmn2r59	UTSW	7	42011946	missense	possibly damaging	0.77
R3912:Vmn2r59	UTSW	7	42046320	missense	probably benign	0.00
R4167:Vmn2r59	UTSW	7	42021308	intron	probably benign
R4357:Vmn2r59	UTSW	7	42012220	missense	probably damaging	1.00
R4445:Vmn2r59	UTSW	7	42042450	missense	probably damaging	1.00
R4542:Vmn2r59	UTSW	7	42046073	missense	possibly damaging	0.93
R4587:Vmn2r59	UTSW	7	42046224	missense	probably benign	0.00
R4616:Vmn2r59	UTSW	7	42012438	missense	probably benign
R4653:Vmn2r59	UTSW	7	42043804	missense	probably benign	0.19
R4703:Vmn2r59	UTSW	7	42012262	missense	probably benign	0.01
R4895:Vmn2r59	UTSW	7	42045794	missense	probably damaging	0.98
R4910:Vmn2r59	UTSW	7	42043653	missense	probably benign
R5045:Vmn2r59	UTSW	7	42046072	missense	possibly damaging	0.93
R5105:Vmn2r59	UTSW	7	42047105	missense	probably benign	0.01
R5153:Vmn2r59	UTSW	7	42042410	critical splice donor site	probably null
R5566:Vmn2r59	UTSW	7	42046823	missense	possibly damaging	0.92
R5586:Vmn2r59	UTSW	7	42045681	missense	probably benign	0.12
R5606:Vmn2r59	UTSW	7	42045894	missense	probably benign	0.27
R5616:Vmn2r59	UTSW	7	42058767	splice site	probably null
R5625:Vmn2r59	UTSW	7	42046460	missense	probably benign	0.03
R5696:Vmn2r59	UTSW	7	42046044	missense	probably benign	0.00
R5982:Vmn2r59	UTSW	7	42046067	missense	probably benign	0.00
R6106:Vmn2r59	UTSW	7	42012325	nonsense	probably null
R6196:Vmn2r59	UTSW	7	42012255	missense	probably benign	0.36
R6228:Vmn2r59	UTSW	7	42042411	critical splice donor site	probably null
R6590:Vmn2r59	UTSW	7	42046466	missense	probably damaging	1.00
R6625:Vmn2r59	UTSW	7	42043753	missense	probably benign	0.02
R6690:Vmn2r59	UTSW	7	42046466	missense	probably damaging	1.00
R6768:Vmn2r59	UTSW	7	42011968	missense	probably benign	0.17
R6830:Vmn2r59	UTSW	7	42043747	missense	probably benign	0.10
R6859:Vmn2r59	UTSW	7	42043853	missense	probably damaging	1.00
R7034:Vmn2r59	UTSW	7	42046220	missense	probably benign	0.03
R7036:Vmn2r59	UTSW	7	42046220	missense	probably benign	0.03
R7145:Vmn2r59	UTSW	7	42045764	missense	probably damaging	1.00
R7556:Vmn2r59	UTSW	7	42045809	missense	probably damaging	1.00
R7733:Vmn2r59	UTSW	7	42012019	missense	probably benign	0.17
R7770:Vmn2r59	UTSW	7	42058912	missense	probably damaging	1.00
R7812:Vmn2r59	UTSW	7	42045772	nonsense	probably null
X0025:Vmn2r59	UTSW	7	42045941	missense	probably damaging	1.00
Z1088:Vmn2r59	UTSW	7	42012414	missense	possibly damaging	0.85

Posted On

2016-08-02