Incidental Mutation 'IGL03346:Or8g24'
ID 417435
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8g24
Ensembl Gene ENSMUSG00000048501
Gene Name olfactory receptor family 8 subfamily G member 24
Synonyms MOR171-25, Olfr938, GA_x6K02T2PVTD-32774646-32773699
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # IGL03346
Quality Score
Status
Chromosome 9
Chromosomal Location 38989092-38990039 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38989258 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 261 (Q261L)
Ref Sequence ENSEMBL: ENSMUSP00000055053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056499]
AlphaFold Q9EQ93
Predicted Effect probably damaging
Transcript: ENSMUST00000056499
AA Change: Q261L

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: Q261L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-49 PFAM
Pfam:7tm_1 41 290 5.5e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175411
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215888
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp13a5 C T 16: 29,133,422 (GRCm39) V410M probably benign Het
Cdkn2aip G T 8: 48,166,653 (GRCm39) D51E probably benign Het
Chd6 A G 2: 160,802,282 (GRCm39) V2184A probably benign Het
Clcn1 C T 6: 42,288,153 (GRCm39) T797I probably benign Het
Cldn23 G A 8: 36,292,594 (GRCm39) probably benign Het
Cntnap4 A G 8: 113,500,208 (GRCm39) D500G probably benign Het
Cog5 A T 12: 31,944,037 (GRCm39) I641F possibly damaging Het
Cr2 A T 1: 194,852,067 (GRCm39) V94E probably damaging Het
Creg2 T G 1: 39,689,915 (GRCm39) D65A probably damaging Het
Dennd4a A G 9: 64,795,808 (GRCm39) R711G possibly damaging Het
Efr3b A G 12: 4,034,648 (GRCm39) V58A probably damaging Het
Fbxo3 A G 2: 103,880,639 (GRCm39) T250A probably damaging Het
Fzr1 T C 10: 81,205,018 (GRCm39) T300A probably benign Het
Gabrg1 A T 5: 70,935,474 (GRCm39) Y227N possibly damaging Het
Gins3 A G 8: 96,369,903 (GRCm39) I197V probably benign Het
Gm17079 T C 14: 51,930,420 (GRCm39) T142A possibly damaging Het
Gna15 T C 10: 81,338,879 (GRCm39) Y320C probably damaging Het
H2-T5 C A 17: 36,479,001 (GRCm39) D83Y probably damaging Het
Hibch G A 1: 52,959,539 (GRCm39) probably benign Het
Kif5b G A 18: 6,222,767 (GRCm39) R355W probably damaging Het
Klf1 T C 8: 85,629,561 (GRCm39) S129P probably benign Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Nat8f5 A G 6: 85,794,640 (GRCm39) S107P probably damaging Het
Or2t49 A G 11: 58,392,581 (GRCm39) L267P possibly damaging Het
Pcdhb18 G A 18: 37,622,674 (GRCm39) M1I probably null Het
Plcb3 A G 19: 6,932,420 (GRCm39) F1080L probably benign Het
Polr2g T C 19: 8,775,669 (GRCm39) H14R probably damaging Het
Rp1l1 A G 14: 64,266,889 (GRCm39) D825G probably benign Het
Scn3a G A 2: 65,367,016 (GRCm39) A2V probably damaging Het
Slc25a54 T C 3: 108,993,046 (GRCm39) probably benign Het
Smad9 C A 3: 54,696,636 (GRCm39) Q234K probably benign Het
Tie1 T C 4: 118,330,025 (GRCm39) Y1066C probably damaging Het
Traf1 T C 2: 34,838,484 (GRCm39) E118G probably benign Het
Ttc21b T C 2: 66,068,192 (GRCm39) D278G possibly damaging Het
Uaca C A 9: 60,761,600 (GRCm39) T204K probably damaging Het
Utrn A T 10: 12,401,096 (GRCm39) Y154N probably benign Het
Virma A G 4: 11,518,984 (GRCm39) T694A probably benign Het
Vmn2r50 T C 7: 9,779,929 (GRCm39) D500G probably damaging Het
Vmn2r59 T A 7: 41,693,253 (GRCm39) H449L probably benign Het
Other mutations in Or8g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Or8g24 APN 9 38,989,747 (GRCm39) missense probably damaging 0.96
IGL01298:Or8g24 APN 9 38,990,020 (GRCm39) missense possibly damaging 0.63
IGL02930:Or8g24 APN 9 38,989,308 (GRCm39) missense probably damaging 1.00
IGL03346:Or8g24 APN 9 38,989,257 (GRCm39) missense probably benign 0.35
IGL03399:Or8g24 APN 9 38,989,533 (GRCm39) nonsense probably null
R0536:Or8g24 UTSW 9 38,989,625 (GRCm39) missense probably benign 0.03
R1170:Or8g24 UTSW 9 38,989,525 (GRCm39) missense possibly damaging 0.50
R1951:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R1952:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R2066:Or8g24 UTSW 9 38,989,510 (GRCm39) missense probably damaging 1.00
R2906:Or8g24 UTSW 9 38,989,669 (GRCm39) missense probably benign 0.39
R4707:Or8g24 UTSW 9 38,989,558 (GRCm39) missense probably benign 0.00
R4767:Or8g24 UTSW 9 38,989,988 (GRCm39) missense possibly damaging 0.71
R4951:Or8g24 UTSW 9 38,989,555 (GRCm39) missense probably benign 0.10
R5888:Or8g24 UTSW 9 38,989,263 (GRCm39) nonsense probably null
R5905:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6028:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6329:Or8g24 UTSW 9 38,989,199 (GRCm39) missense probably benign 0.02
R7240:Or8g24 UTSW 9 38,989,906 (GRCm39) missense probably damaging 0.99
R7345:Or8g24 UTSW 9 38,989,630 (GRCm39) missense probably damaging 1.00
R8058:Or8g24 UTSW 9 38,989,862 (GRCm39) missense probably damaging 1.00
R9023:Or8g24 UTSW 9 38,989,307 (GRCm39) missense probably benign 0.09
R9547:Or8g24 UTSW 9 38,989,927 (GRCm39) missense probably damaging 0.99
R9682:Or8g24 UTSW 9 38,989,874 (GRCm39) missense possibly damaging 0.95
R9760:Or8g24 UTSW 9 38,989,271 (GRCm39) missense possibly damaging 0.95
X0062:Or8g24 UTSW 9 38,989,762 (GRCm39) missense probably benign 0.15
Posted On 2016-08-02