Incidental Mutation 'IGL03346:Gna15'
ID 417463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gna15
Ensembl Gene ENSMUSG00000034792
Gene Name guanine nucleotide binding protein, alpha 15
Synonyms Galpha15, G[a]15
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.258) question?
Stock # IGL03346
Quality Score
Status
Chromosome 10
Chromosomal Location 81502306-81524225 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 81503045 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 320 (Y320C)
Ref Sequence ENSEMBL: ENSMUSP00000049175 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043709] [ENSMUST00000053646]
AlphaFold P30678
Predicted Effect probably damaging
Transcript: ENSMUST00000043709
AA Change: Y320C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000049175
Gene: ENSMUSG00000034792
AA Change: Y320C

DomainStartEndE-ValueType
G_alpha 22 373 1.22e-188 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000053646
SMART Domains Protein: ENSMUSP00000050412
Gene: ENSMUSG00000044199

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
Pfam:7tm_1 66 309 1.2e-32 PFAM
low complexity region 324 337 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000102273
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119187
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147908
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150586
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit normal hematopoiesis and normal response to inflammatory challenges. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp13a5 C T 16: 29,314,604 V410M probably benign Het
Cdkn2aip G T 8: 47,713,618 D51E probably benign Het
Chd6 A G 2: 160,960,362 V2184A probably benign Het
Clcn1 C T 6: 42,311,219 T797I probably benign Het
Cldn23 G A 8: 35,825,440 probably benign Het
Cntnap4 A G 8: 112,773,576 D500G probably benign Het
Cog5 A T 12: 31,894,038 I641F possibly damaging Het
Cr2 A T 1: 195,169,759 V94E probably damaging Het
Creg2 T G 1: 39,650,747 D65A probably damaging Het
Dennd4a A G 9: 64,888,526 R711G possibly damaging Het
Efr3b A G 12: 3,984,648 V58A probably damaging Het
Fbxo3 A G 2: 104,050,294 T250A probably damaging Het
Fzr1 T C 10: 81,369,184 T300A probably benign Het
Gabrg1 A T 5: 70,778,131 Y227N possibly damaging Het
Gins3 A G 8: 95,643,275 I197V probably benign Het
Gm17079 T C 14: 51,692,963 T142A possibly damaging Het
Gm8909 C A 17: 36,168,109 D83Y probably damaging Het
Hibch G A 1: 52,920,380 probably benign Het
Kif5b G A 18: 6,222,767 R355W probably damaging Het
Klf1 T C 8: 84,902,932 S129P probably benign Het
Lyl1 C T 8: 84,702,671 P3L possibly damaging Het
Nat8f5 A G 6: 85,817,658 S107P probably damaging Het
Olfr331 A G 11: 58,501,755 L267P possibly damaging Het
Olfr938 C A 9: 39,077,961 Q261H probably benign Het
Olfr938 T A 9: 39,077,962 Q261L probably damaging Het
Pcdhb18 G A 18: 37,489,621 M1I probably null Het
Plcb3 A G 19: 6,955,052 F1080L probably benign Het
Polr2g T C 19: 8,798,305 H14R probably damaging Het
Rp1l1 A G 14: 64,029,440 D825G probably benign Het
Scn3a G A 2: 65,536,672 A2V probably damaging Het
Slc25a54 T C 3: 109,085,730 probably benign Het
Smad9 C A 3: 54,789,215 Q234K probably benign Het
Tie1 T C 4: 118,472,828 Y1066C probably damaging Het
Traf1 T C 2: 34,948,472 E118G probably benign Het
Ttc21b T C 2: 66,237,848 D278G possibly damaging Het
Uaca C A 9: 60,854,318 T204K probably damaging Het
Utrn A T 10: 12,525,352 Y154N probably benign Het
Virma A G 4: 11,518,984 T694A probably benign Het
Vmn2r50 T C 7: 10,046,002 D500G probably damaging Het
Vmn2r59 T A 7: 42,043,829 H449L probably benign Het
Other mutations in Gna15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02337:Gna15 APN 10 81514410 missense probably damaging 1.00
R0062:Gna15 UTSW 10 81512405 splice site probably null
R0062:Gna15 UTSW 10 81512405 splice site probably null
R0464:Gna15 UTSW 10 81512504 missense probably benign 0.15
R0732:Gna15 UTSW 10 81512556 missense probably damaging 0.97
R1529:Gna15 UTSW 10 81509342 missense probably damaging 1.00
R1768:Gna15 UTSW 10 81512120 missense probably damaging 1.00
R2151:Gna15 UTSW 10 81502904 missense probably damaging 1.00
R2153:Gna15 UTSW 10 81502904 missense probably damaging 1.00
R5575:Gna15 UTSW 10 81523873 missense probably damaging 1.00
R5750:Gna15 UTSW 10 81509396 nonsense probably null
R5790:Gna15 UTSW 10 81509384 missense probably damaging 1.00
R6123:Gna15 UTSW 10 81509344 missense probably damaging 1.00
R6222:Gna15 UTSW 10 81512046 missense probably damaging 1.00
R6750:Gna15 UTSW 10 81514283 missense probably benign
R7138:Gna15 UTSW 10 81508047 missense probably damaging 1.00
R7426:Gna15 UTSW 10 81502997 missense probably benign 0.03
R7542:Gna15 UTSW 10 81514302 missense probably damaging 1.00
R7802:Gna15 UTSW 10 81514341 missense probably benign 0.28
R7942:Gna15 UTSW 10 81523911 missense probably damaging 0.98
R9168:Gna15 UTSW 10 81514358 missense probably damaging 1.00
R9188:Gna15 UTSW 10 81507964 missense probably benign 0.43
R9206:Gna15 UTSW 10 81509390 missense probably benign 0.25
R9208:Gna15 UTSW 10 81509390 missense probably benign 0.25
R9237:Gna15 UTSW 10 81523849 missense possibly damaging 0.83
R9695:Gna15 UTSW 10 81523918 missense probably damaging 1.00
Posted On 2016-08-02