Incidental Mutation 'IGL03071:Zfp386'
ID417506
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp386
Ensembl Gene ENSMUSG00000042063
Gene Namezinc finger protein 386 (Kruppel-like)
Synonyms
Accession Numbers

Genbank: NM_001004066, NM_019565

Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL03071
Quality Score
Status
Chromosome12
Chromosomal Location116047724-116063360 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 116059140 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Glutamine at position 124 (H124Q)
Ref Sequence ENSEMBL: ENSMUSP00000073241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073551] [ENSMUST00000183125]
Predicted Effect probably benign
Transcript: ENSMUST00000073551
AA Change: H124Q

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000073241
Gene: ENSMUSG00000042063
AA Change: H124Q

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182566
Predicted Effect probably benign
Transcript: ENSMUST00000183125
AA Change: H159Q

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000138305
Gene: ENSMUSG00000042063
AA Change: H159Q

DomainStartEndE-ValueType
KRAB 6 66 1.88e-19 SMART
ZnF_C2H2 379 401 4.72e-2 SMART
ZnF_C2H2 407 429 6.42e-4 SMART
ZnF_C2H2 435 457 5.14e-3 SMART
ZnF_C2H2 463 485 2.09e-3 SMART
ZnF_C2H2 491 513 6.42e-4 SMART
ZnF_C2H2 519 541 4.87e-4 SMART
ZnF_C2H2 547 569 1.28e-3 SMART
ZnF_C2H2 575 597 2.2e-2 SMART
ZnF_C2H2 603 625 5.99e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(4) : Gene trapped(4)

Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam39 T A 8: 40,825,067 L165H probably benign Het
Ahnak T C 19: 9,011,918 I3522T possibly damaging Het
Anks1 G A 17: 28,008,199 A609T probably benign Het
Apaf1 T C 10: 90,997,255 D1138G possibly damaging Het
Appl2 T C 10: 83,641,106 probably null Het
Arhgef19 A T 4: 141,249,002 I385F possibly damaging Het
Cby3 A G 11: 50,359,516 D183G probably damaging Het
Ccdc134 G A 15: 82,134,625 V119M possibly damaging Het
Ccdc180 G T 4: 45,903,840 probably benign Het
Clec2d T C 6: 129,183,202 S60P probably benign Het
Cts6 A T 13: 61,202,250 F6I probably damaging Het
Cyyr1 G A 16: 85,465,561 H103Y probably damaging Het
Dopey1 T A 9: 86,489,615 S120T possibly damaging Het
Dot1l T C 10: 80,788,679 S994P probably benign Het
Eya4 T G 10: 23,323,073 D3A probably benign Het
Fam160b2 A G 14: 70,586,209 C574R probably damaging Het
Fut2 C T 7: 45,650,769 G193E possibly damaging Het
Gria1 A T 11: 57,012,110 probably null Het
Hectd1 T C 12: 51,769,174 T1377A probably benign Het
Magi3 T G 3: 104,015,886 K1172Q possibly damaging Het
Map3k1 A C 13: 111,755,525 D1065E possibly damaging Het
Mindy4b-ps A T 3: 58,809,737 V242D probably damaging Het
Mrgpra3 T C 7: 47,589,181 probably benign Het
Mroh9 C A 1: 163,039,197 G657C probably damaging Het
Ogfod1 T C 8: 94,057,767 W318R probably damaging Het
Olfr16 A G 1: 172,956,935 T47A probably benign Het
Pacsin3 G A 2: 91,260,492 R48H probably damaging Het
Plcb1 A G 2: 135,387,802 E1114G probably damaging Het
Prkdc T G 16: 15,799,984 D3226E probably benign Het
Prl4a1 A T 13: 28,020,263 E96V probably benign Het
Robo4 T C 9: 37,404,284 probably benign Het
Scn7a G A 2: 66,699,947 L685F possibly damaging Het
Spata1 A G 3: 146,475,334 Y290H possibly damaging Het
Tex10 T C 4: 48,452,946 D671G probably benign Het
Tifa T G 3: 127,797,079 Y166* probably null Het
Tnfsf10 G A 3: 27,335,620 D277N probably damaging Het
Tram1 A T 1: 13,579,774 Y75* probably null Het
Vmn1r60 T A 7: 5,544,369 N244I probably damaging Het
Xpo4 A G 14: 57,618,228 I248T possibly damaging Het
Zc2hc1a A G 3: 7,524,122 probably benign Het
Other mutations in Zfp386
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01982:Zfp386 APN 12 116059168 missense probably benign
IGL02692:Zfp386 APN 12 116059235 missense probably damaging 0.96
F5493:Zfp386 UTSW 12 116060302 missense probably damaging 0.99
R0098:Zfp386 UTSW 12 116059214 nonsense probably null
R0098:Zfp386 UTSW 12 116059214 nonsense probably null
R0372:Zfp386 UTSW 12 116054816 missense possibly damaging 0.71
R0784:Zfp386 UTSW 12 116059920 nonsense probably null
R0866:Zfp386 UTSW 12 116054709 splice site probably benign
R0947:Zfp386 UTSW 12 116059778 missense probably benign 0.11
R1080:Zfp386 UTSW 12 116059806 nonsense probably null
R1517:Zfp386 UTSW 12 116059605 missense possibly damaging 0.67
R1597:Zfp386 UTSW 12 116060089 missense probably damaging 0.99
R1722:Zfp386 UTSW 12 116059906 missense probably damaging 0.99
R2043:Zfp386 UTSW 12 116059161 missense probably benign 0.22
R3741:Zfp386 UTSW 12 116059550 nonsense probably null
R3742:Zfp386 UTSW 12 116059550 nonsense probably null
R3902:Zfp386 UTSW 12 116060155 missense probably damaging 1.00
R5012:Zfp386 UTSW 12 116059244 missense probably benign
R5590:Zfp386 UTSW 12 116059727 missense probably benign 0.41
R5709:Zfp386 UTSW 12 116059685 missense probably benign 0.23
R6156:Zfp386 UTSW 12 116059906 missense probably damaging 0.99
R6184:Zfp386 UTSW 12 116060513 missense possibly damaging 0.64
R6423:Zfp386 UTSW 12 116060113 missense probably damaging 0.96
R8015:Zfp386 UTSW 12 116059407 missense probably damaging 0.96
R8120:Zfp386 UTSW 12 116054953 missense unknown
R8137:Zfp386 UTSW 12 116059648 missense possibly damaging 0.91
Z1088:Zfp386 UTSW 12 116054773 missense possibly damaging 0.95
Posted On2016-08-02