Incidental Mutation 'IGL03073:Olfr1098'
ID417574
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1098
Ensembl Gene ENSMUSG00000075169
Gene Nameolfactory receptor 1098
SynonymsMOR206-1, GA_x6K02T2Q125-48410458-48409511
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL03073
Quality Score
Status
Chromosome2
Chromosomal Location86920949-86924545 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 86923353 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Histidine at position 60 (Y60H)
Ref Sequence ENSEMBL: ENSMUSP00000107200 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099872] [ENSMUST00000111574]
Predicted Effect probably damaging
Transcript: ENSMUST00000099872
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097457
Gene: ENSMUSG00000075169
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 7e-29 PFAM
Pfam:7tm_4 140 283 3.3e-41 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111574
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000107200
Gene: ENSMUSG00000075169
AA Change: Y60H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.8e-52 PFAM
Pfam:7tm_1 41 309 8.1e-20 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930504O13Rik A T 11: 58,447,451 D38E probably damaging Het
4933440M02Rik T C 7: 125,331,563 noncoding transcript Het
Actr6 A G 10: 89,726,694 S108P probably damaging Het
Adam34 A T 8: 43,650,903 N568K probably damaging Het
Anpep A G 7: 79,838,955 L408P probably damaging Het
Atp13a1 T C 8: 69,798,502 V459A probably damaging Het
Atp2b1 C T 10: 98,999,851 T486M probably damaging Het
Cdc42bpa T A 1: 180,094,376 probably benign Het
Espnl T C 1: 91,344,556 I502T probably damaging Het
Fancm T C 12: 65,101,632 Y674H probably damaging Het
Gnaq T A 19: 16,316,106 N137K probably benign Het
Igf1r T A 7: 68,215,043 D1196E probably damaging Het
Insrr A G 3: 87,809,938 probably benign Het
Mcf2l C A 8: 13,000,004 H313N probably damaging Het
Mdh1b C T 1: 63,721,487 probably null Het
Mrc1 G A 2: 14,305,342 V805I probably damaging Het
Ncam2 T G 16: 81,621,347 D763E possibly damaging Het
Ncapg2 T G 12: 116,452,274 H1091Q probably benign Het
Olfr1466 T G 19: 13,342,022 I88R probably benign Het
Pcdh18 T A 3: 49,753,367 D886V possibly damaging Het
Pdlim4 A G 11: 54,063,641 V21A probably damaging Het
Safb2 A G 17: 56,571,289 S24P probably benign Het
Sec16a A G 2: 26,439,183 M940T probably benign Het
Snx14 A G 9: 88,422,896 probably null Het
Sox1 T C 8: 12,396,625 W89R probably damaging Het
Stx12 T C 4: 132,858,449 M207V probably benign Het
Tex14 A G 11: 87,535,609 T1154A probably damaging Het
Tmcc3 T G 10: 94,578,951 S172A probably benign Het
Tnc T A 4: 63,971,224 I1773F possibly damaging Het
Tshz3 A T 7: 36,770,745 N720Y probably damaging Het
Usp19 G A 9: 108,495,803 probably benign Het
Vmn1r170 A C 7: 23,606,848 Q225P probably damaging Het
Vmn2r89 A G 14: 51,456,071 I293V possibly damaging Het
Other mutations in Olfr1098
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01318:Olfr1098 APN 2 86922949 missense probably benign
IGL02547:Olfr1098 APN 2 86923028 missense probably damaging 1.00
IGL02881:Olfr1098 APN 2 86922713 missense possibly damaging 0.94
R0117:Olfr1098 UTSW 2 86922870 missense probably damaging 1.00
R0808:Olfr1098 UTSW 2 86923451 missense probably damaging 1.00
R1061:Olfr1098 UTSW 2 86922782 missense possibly damaging 0.93
R1471:Olfr1098 UTSW 2 86922578 splice site probably null
R1571:Olfr1098 UTSW 2 86923445 missense probably benign 0.01
R1680:Olfr1098 UTSW 2 86923161 missense probably benign 0.10
R2341:Olfr1098 UTSW 2 86922638 missense possibly damaging 0.63
R2368:Olfr1098 UTSW 2 86923107 missense probably benign
R3158:Olfr1098 UTSW 2 86922606 missense probably benign
R3425:Olfr1098 UTSW 2 86922606 missense probably benign
R3499:Olfr1098 UTSW 2 86923029 missense possibly damaging 0.94
R4156:Olfr1098 UTSW 2 86922878 missense probably damaging 1.00
R4526:Olfr1098 UTSW 2 86922995 missense possibly damaging 0.90
R5743:Olfr1098 UTSW 2 86923205 missense probably benign 0.01
R5942:Olfr1098 UTSW 2 86923406 missense probably damaging 1.00
R6372:Olfr1098 UTSW 2 86923155 missense probably damaging 1.00
R6409:Olfr1098 UTSW 2 86923171 nonsense probably null
R6517:Olfr1098 UTSW 2 86923097 missense probably benign 0.05
R6661:Olfr1098 UTSW 2 86923148 missense probably benign 0.02
R7075:Olfr1098 UTSW 2 86922646 missense possibly damaging 0.88
R7166:Olfr1098 UTSW 2 86922748 missense probably damaging 0.97
R8058:Olfr1098 UTSW 2 86922807 missense probably benign 0.32
R8234:Olfr1098 UTSW 2 86922969 missense probably damaging 1.00
Posted On2016-08-02