Incidental Mutation 'IGL03073:Vmn1r170'
| ID |
417575 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r170
|
| Ensembl Gene |
ENSMUSG00000094187 |
| Gene Name |
vomeronasal 1 receptor 170 |
| Synonyms |
Gm5999 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
IGL03073
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
23305600-23306514 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 23306273 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Proline
at position 225
(Q225P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127655
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170166]
|
| AlphaFold |
K7N6W9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170166
AA Change: Q225P
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000127655
Gene: ENSMUSG00000094187
AA Change: Q225P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
8 |
296 |
1.8e-13 |
PFAM |
|
Pfam:7tm_1
|
30 |
287 |
3.6e-6 |
PFAM |
|
Pfam:V1R
|
42 |
295 |
1.4e-20 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933440M02Rik |
T |
C |
7: 124,930,735 (GRCm39) |
|
noncoding transcript |
Het |
| Actr6 |
A |
G |
10: 89,562,556 (GRCm39) |
S108P |
probably damaging |
Het |
| Adam34 |
A |
T |
8: 44,103,940 (GRCm39) |
N568K |
probably damaging |
Het |
| Anpep |
A |
G |
7: 79,488,703 (GRCm39) |
L408P |
probably damaging |
Het |
| Atp13a1 |
T |
C |
8: 70,251,152 (GRCm39) |
V459A |
probably damaging |
Het |
| Atp2b1 |
C |
T |
10: 98,835,713 (GRCm39) |
T486M |
probably damaging |
Het |
| Cdc42bpa |
T |
A |
1: 179,921,941 (GRCm39) |
|
probably benign |
Het |
| Espnl |
T |
C |
1: 91,272,278 (GRCm39) |
I502T |
probably damaging |
Het |
| Fancm |
T |
C |
12: 65,148,406 (GRCm39) |
Y674H |
probably damaging |
Het |
| Gnaq |
T |
A |
19: 16,293,470 (GRCm39) |
N137K |
probably benign |
Het |
| Igf1r |
T |
A |
7: 67,864,791 (GRCm39) |
D1196E |
probably damaging |
Het |
| Insrr |
A |
G |
3: 87,717,245 (GRCm39) |
|
probably benign |
Het |
| Lypd9 |
A |
T |
11: 58,338,277 (GRCm39) |
D38E |
probably damaging |
Het |
| Mcf2l |
C |
A |
8: 13,050,004 (GRCm39) |
H313N |
probably damaging |
Het |
| Mdh1b |
C |
T |
1: 63,760,646 (GRCm39) |
|
probably null |
Het |
| Mrc1 |
G |
A |
2: 14,310,153 (GRCm39) |
V805I |
probably damaging |
Het |
| Ncam2 |
T |
G |
16: 81,418,235 (GRCm39) |
D763E |
possibly damaging |
Het |
| Ncapg2 |
T |
G |
12: 116,415,894 (GRCm39) |
H1091Q |
probably benign |
Het |
| Or5b112 |
T |
G |
19: 13,319,386 (GRCm39) |
I88R |
probably benign |
Het |
| Or8h8 |
A |
G |
2: 86,753,697 (GRCm39) |
Y60H |
probably damaging |
Het |
| Pcdh18 |
T |
A |
3: 49,707,816 (GRCm39) |
D886V |
possibly damaging |
Het |
| Pdlim4 |
A |
G |
11: 53,954,467 (GRCm39) |
V21A |
probably damaging |
Het |
| Safb2 |
A |
G |
17: 56,878,289 (GRCm39) |
S24P |
probably benign |
Het |
| Sec16a |
A |
G |
2: 26,329,195 (GRCm39) |
M940T |
probably benign |
Het |
| Snx14 |
A |
G |
9: 88,304,949 (GRCm39) |
|
probably null |
Het |
| Sox1 |
T |
C |
8: 12,446,625 (GRCm39) |
W89R |
probably damaging |
Het |
| Stx12 |
T |
C |
4: 132,585,760 (GRCm39) |
M207V |
probably benign |
Het |
| Tex14 |
A |
G |
11: 87,426,435 (GRCm39) |
T1154A |
probably damaging |
Het |
| Tmcc3 |
T |
G |
10: 94,414,813 (GRCm39) |
S172A |
probably benign |
Het |
| Tnc |
T |
A |
4: 63,889,461 (GRCm39) |
I1773F |
possibly damaging |
Het |
| Tshz3 |
A |
T |
7: 36,470,170 (GRCm39) |
N720Y |
probably damaging |
Het |
| Usp19 |
G |
A |
9: 108,373,002 (GRCm39) |
|
probably benign |
Het |
| Vmn2r89 |
A |
G |
14: 51,693,528 (GRCm39) |
I293V |
possibly damaging |
Het |
|
| Other mutations in Vmn1r170 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02005:Vmn1r170
|
APN |
7 |
23,306,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02150:Vmn1r170
|
APN |
7 |
23,306,465 (GRCm39) |
nonsense |
probably null |
|
|
IGL02216:Vmn1r170
|
APN |
7 |
23,305,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02749:Vmn1r170
|
APN |
7 |
23,305,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02807:Vmn1r170
|
APN |
7 |
23,305,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02828:Vmn1r170
|
APN |
7 |
23,305,943 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02971:Vmn1r170
|
APN |
7 |
23,305,759 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03151:Vmn1r170
|
APN |
7 |
23,306,002 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0079:Vmn1r170
|
UTSW |
7 |
23,305,735 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0266:Vmn1r170
|
UTSW |
7 |
23,305,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0980:Vmn1r170
|
UTSW |
7 |
23,305,759 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1345:Vmn1r170
|
UTSW |
7 |
23,305,787 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1620:Vmn1r170
|
UTSW |
7 |
23,305,754 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1713:Vmn1r170
|
UTSW |
7 |
23,306,288 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1745:Vmn1r170
|
UTSW |
7 |
23,305,759 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1974:Vmn1r170
|
UTSW |
7 |
23,305,906 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2163:Vmn1r170
|
UTSW |
7 |
23,306,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3812:Vmn1r170
|
UTSW |
7 |
23,305,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4583:Vmn1r170
|
UTSW |
7 |
23,306,087 (GRCm39) |
missense |
probably benign |
0.25 |
|
R5309:Vmn1r170
|
UTSW |
7 |
23,305,880 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5378:Vmn1r170
|
UTSW |
7 |
23,305,963 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5379:Vmn1r170
|
UTSW |
7 |
23,306,054 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5661:Vmn1r170
|
UTSW |
7 |
23,306,231 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5673:Vmn1r170
|
UTSW |
7 |
23,305,630 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R6181:Vmn1r170
|
UTSW |
7 |
23,305,692 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6192:Vmn1r170
|
UTSW |
7 |
23,305,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7467:Vmn1r170
|
UTSW |
7 |
23,306,320 (GRCm39) |
missense |
not run |
|
|
R7667:Vmn1r170
|
UTSW |
7 |
23,306,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8458:Vmn1r170
|
UTSW |
7 |
23,306,321 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8699:Vmn1r170
|
UTSW |
7 |
23,306,080 (GRCm39) |
nonsense |
probably null |
|
|
R8927:Vmn1r170
|
UTSW |
7 |
23,305,814 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8928:Vmn1r170
|
UTSW |
7 |
23,305,814 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9269:Vmn1r170
|
UTSW |
7 |
23,306,263 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9569:Vmn1r170
|
UTSW |
7 |
23,306,294 (GRCm39) |
missense |
probably benign |
0.19 |
|
X0060:Vmn1r170
|
UTSW |
7 |
23,306,368 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
Z1176:Vmn1r170
|
UTSW |
7 |
23,305,835 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Posted On |
2016-08-02 |
Incidental Mutation