Incidental Mutation 'IGL03074:Zfp366'
| ID |
417627 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp366
|
| Ensembl Gene |
ENSMUSG00000050919 |
| Gene Name |
zinc finger protein 366 |
| Synonyms |
DC-SCRIPT |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.331)
|
| Stock # |
IGL03074
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
13 |
| Chromosomal Location |
99321331-99383540 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 99382913 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 692
(D692G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000060040
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000056558]
|
| AlphaFold |
Q6NS86 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000056558
AA Change: D692G
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000060040
Gene: ENSMUSG00000050919
AA Change: D692G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
159 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
196 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
250 |
272 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
278 |
300 |
4.05e-1 |
SMART |
|
ZnF_C2H2
|
306 |
328 |
1.79e-2 |
SMART |
|
ZnF_C2H2
|
334 |
356 |
1.53e-1 |
SMART |
|
ZnF_C2H2
|
362 |
384 |
1.89e-1 |
SMART |
|
ZnF_C2H2
|
390 |
412 |
1.22e-4 |
SMART |
|
ZnF_C2H2
|
418 |
440 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
446 |
468 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
474 |
496 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
502 |
524 |
5.42e-2 |
SMART |
|
ZnF_C2H2
|
530 |
553 |
2.4e-3 |
SMART |
|
low complexity region
|
615 |
623 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit perimembranous and muscular ventricular septal defects (VSD), and overriding aorta. Short snout, micrognathia, micropthalmia, hypoplastic thymus, and hydronephrosis are also observed. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
T |
A |
11: 110,201,101 (GRCm39) |
Y433F |
probably benign |
Het |
| Ank2 |
C |
A |
3: 126,749,519 (GRCm39) |
E503D |
probably damaging |
Het |
| Anks4b |
A |
T |
7: 119,781,140 (GRCm39) |
D57V |
probably damaging |
Het |
| Brwd1 |
A |
G |
16: 95,813,050 (GRCm39) |
V1486A |
probably benign |
Het |
| Cd163 |
A |
G |
6: 124,294,945 (GRCm39) |
T670A |
probably benign |
Het |
| Dmtf1 |
T |
C |
5: 9,174,435 (GRCm39) |
|
probably benign |
Het |
| Dnajc22 |
T |
A |
15: 98,999,403 (GRCm39) |
L196Q |
probably damaging |
Het |
| Dock9 |
A |
G |
14: 121,844,682 (GRCm39) |
L1097P |
possibly damaging |
Het |
| Dtna |
T |
C |
18: 23,735,662 (GRCm39) |
V339A |
possibly damaging |
Het |
| Dysf |
T |
A |
6: 84,165,208 (GRCm39) |
S1646T |
probably benign |
Het |
| Ermp1 |
A |
T |
19: 29,589,935 (GRCm39) |
Y893N |
probably damaging |
Het |
| Etv6 |
A |
T |
6: 134,199,888 (GRCm39) |
N76I |
probably damaging |
Het |
| Farp2 |
T |
C |
1: 93,488,049 (GRCm39) |
V92A |
probably benign |
Het |
| Fgf21 |
T |
C |
7: 45,263,605 (GRCm39) |
T158A |
probably benign |
Het |
| Gcm1 |
T |
C |
9: 77,972,057 (GRCm39) |
S333P |
possibly damaging |
Het |
| Grm7 |
T |
A |
6: 111,472,604 (GRCm39) |
|
probably null |
Het |
| Itgae |
T |
C |
11: 73,016,136 (GRCm39) |
F782L |
probably benign |
Het |
| Kbtbd8 |
A |
G |
6: 95,099,333 (GRCm39) |
T204A |
probably damaging |
Het |
| Kcp |
A |
G |
6: 29,496,630 (GRCm39) |
C627R |
probably damaging |
Het |
| Loxhd1 |
T |
C |
18: 77,529,480 (GRCm39) |
V2041A |
possibly damaging |
Het |
| Mcm5 |
T |
C |
8: 75,845,929 (GRCm39) |
M379T |
possibly damaging |
Het |
| Mcu |
A |
G |
10: 59,303,580 (GRCm39) |
S86P |
probably damaging |
Het |
| Naa25 |
T |
C |
5: 121,546,400 (GRCm39) |
|
probably null |
Het |
| Or10ag59 |
T |
A |
2: 87,405,680 (GRCm39) |
L84H |
possibly damaging |
Het |
| Or5b117 |
A |
G |
19: 13,431,417 (GRCm39) |
S155P |
probably damaging |
Het |
| Osbpl9 |
T |
C |
4: 108,929,158 (GRCm39) |
H400R |
probably damaging |
Het |
| Pip5kl1 |
A |
G |
2: 32,470,353 (GRCm39) |
N278D |
probably damaging |
Het |
| Ppp1r12b |
T |
C |
1: 134,763,758 (GRCm39) |
T759A |
probably benign |
Het |
| Psg27 |
T |
C |
7: 18,294,454 (GRCm39) |
T318A |
probably benign |
Het |
| Rtkn2 |
T |
G |
10: 67,877,551 (GRCm39) |
L537R |
probably damaging |
Het |
| Sdr39u1 |
C |
T |
14: 56,137,103 (GRCm39) |
|
probably null |
Het |
| Slc38a1 |
A |
T |
15: 96,490,405 (GRCm39) |
I124N |
possibly damaging |
Het |
| Sumf2 |
T |
A |
5: 129,888,674 (GRCm39) |
|
probably benign |
Het |
| Thsd7a |
A |
G |
6: 12,324,680 (GRCm39) |
Y1464H |
probably damaging |
Het |
| Unc80 |
C |
T |
1: 66,710,877 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp366 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00585:Zfp366
|
APN |
13 |
99,383,080 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01626:Zfp366
|
APN |
13 |
99,364,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02227:Zfp366
|
APN |
13 |
99,370,696 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0126:Zfp366
|
UTSW |
13 |
99,365,129 (GRCm39) |
missense |
probably benign |
0.14 |
|
R0145:Zfp366
|
UTSW |
13 |
99,366,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Zfp366
|
UTSW |
13 |
99,370,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0234:Zfp366
|
UTSW |
13 |
99,370,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0376:Zfp366
|
UTSW |
13 |
99,370,759 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0537:Zfp366
|
UTSW |
13 |
99,365,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0637:Zfp366
|
UTSW |
13 |
99,365,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0838:Zfp366
|
UTSW |
13 |
99,365,118 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1386:Zfp366
|
UTSW |
13 |
99,383,063 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1422:Zfp366
|
UTSW |
13 |
99,365,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1669:Zfp366
|
UTSW |
13 |
99,366,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1839:Zfp366
|
UTSW |
13 |
99,365,000 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3751:Zfp366
|
UTSW |
13 |
99,365,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Zfp366
|
UTSW |
13 |
99,382,991 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4908:Zfp366
|
UTSW |
13 |
99,370,609 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4992:Zfp366
|
UTSW |
13 |
99,366,003 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5040:Zfp366
|
UTSW |
13 |
99,364,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Zfp366
|
UTSW |
13 |
99,365,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5186:Zfp366
|
UTSW |
13 |
99,382,676 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5249:Zfp366
|
UTSW |
13 |
99,366,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5450:Zfp366
|
UTSW |
13 |
99,366,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6838:Zfp366
|
UTSW |
13 |
99,382,685 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6838:Zfp366
|
UTSW |
13 |
99,365,015 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7250:Zfp366
|
UTSW |
13 |
99,366,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7378:Zfp366
|
UTSW |
13 |
99,366,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7571:Zfp366
|
UTSW |
13 |
99,382,895 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7624:Zfp366
|
UTSW |
13 |
99,382,804 (GRCm39) |
missense |
probably benign |
|
|
R7653:Zfp366
|
UTSW |
13 |
99,365,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8367:Zfp366
|
UTSW |
13 |
99,380,551 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9510:Zfp366
|
UTSW |
13 |
99,365,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Zfp366
|
UTSW |
13 |
99,365,435 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9734:Zfp366
|
UTSW |
13 |
99,365,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Zfp366
|
UTSW |
13 |
99,382,858 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation