Incidental Mutation 'IGL03076:Zfp128'
| ID |
417684 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp128
|
| Ensembl Gene |
ENSMUSG00000060397 |
| Gene Name |
zinc finger protein 128 |
| Synonyms |
mZnf8, 9630016P15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.096)
|
| Stock # |
IGL03076
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12615105-12627349 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 12618636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 45
(T45A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115378
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000144578]
|
| AlphaFold |
Q8BGV5 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000081891
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000144578
AA Change: T45A
PolyPhen 2
Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000115378
Gene: ENSMUSG00000060397
AA Change: T45A
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
85 |
2.51e-38 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
464 |
486 |
3.39e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ankmy2 |
T |
C |
12: 36,215,917 (GRCm39) |
V39A |
probably damaging |
Het |
| Bcl2 |
A |
G |
1: 106,471,037 (GRCm39) |
V223A |
probably benign |
Het |
| Bsn |
T |
A |
9: 107,982,581 (GRCm39) |
Y3724F |
unknown |
Het |
| Chd8 |
T |
C |
14: 52,463,619 (GRCm39) |
|
probably benign |
Het |
| Cyp2a5 |
T |
C |
7: 26,535,299 (GRCm39) |
V87A |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,807,226 (GRCm39) |
|
probably null |
Het |
| Dync1h1 |
C |
T |
12: 110,624,327 (GRCm39) |
R3652W |
probably damaging |
Het |
| Epha5 |
T |
A |
5: 84,479,549 (GRCm39) |
T152S |
probably damaging |
Het |
| Flnb |
T |
G |
14: 7,901,988 (GRCm38) |
N950K |
probably benign |
Het |
| Fmn1 |
A |
G |
2: 113,414,437 (GRCm39) |
D1128G |
probably damaging |
Het |
| Fndc3a |
T |
A |
14: 72,793,908 (GRCm39) |
T922S |
possibly damaging |
Het |
| Fsip2 |
A |
T |
2: 82,812,482 (GRCm39) |
N2934Y |
possibly damaging |
Het |
| Gnptab |
T |
C |
10: 88,276,151 (GRCm39) |
V1146A |
possibly damaging |
Het |
| Gsg1l |
A |
G |
7: 125,522,665 (GRCm39) |
F188L |
probably benign |
Het |
| Kmt2c |
C |
A |
5: 25,504,149 (GRCm39) |
E309* |
probably null |
Het |
| Krt71 |
C |
T |
15: 101,643,032 (GRCm39) |
R492H |
probably benign |
Het |
| Lama1 |
T |
A |
17: 68,023,794 (GRCm39) |
V63E |
possibly damaging |
Het |
| Lrch3 |
T |
C |
16: 32,802,223 (GRCm39) |
V58A |
possibly damaging |
Het |
| Lrrc8b |
T |
A |
5: 105,629,415 (GRCm39) |
L587Q |
probably damaging |
Het |
| Lrrtm1 |
T |
C |
6: 77,221,568 (GRCm39) |
C342R |
probably damaging |
Het |
| Mdm1 |
T |
C |
10: 117,995,588 (GRCm39) |
S541P |
possibly damaging |
Het |
| Mdn1 |
T |
A |
4: 32,735,564 (GRCm39) |
V3410D |
probably damaging |
Het |
| Neb |
G |
A |
2: 52,059,100 (GRCm39) |
H213Y |
probably damaging |
Het |
| Or52p2 |
A |
T |
7: 102,237,679 (GRCm39) |
N90K |
probably benign |
Het |
| Or7e175 |
T |
C |
9: 20,049,023 (GRCm39) |
S204P |
probably benign |
Het |
| Pigt |
A |
G |
2: 164,339,585 (GRCm39) |
E36G |
probably damaging |
Het |
| Plxnb1 |
T |
A |
9: 108,935,970 (GRCm39) |
V1120D |
probably damaging |
Het |
| Rapgef6 |
T |
C |
11: 54,516,793 (GRCm39) |
L350P |
probably damaging |
Het |
| Rasgef1c |
C |
A |
11: 49,861,073 (GRCm39) |
T302K |
probably damaging |
Het |
| Riox2 |
C |
A |
16: 59,311,575 (GRCm39) |
A386D |
possibly damaging |
Het |
| Semp2l1 |
A |
G |
1: 32,584,626 (GRCm39) |
I428T |
probably damaging |
Het |
| Slc12a2 |
T |
C |
18: 58,059,469 (GRCm39) |
|
probably benign |
Het |
| Trim24 |
T |
A |
6: 37,942,567 (GRCm39) |
S992R |
probably damaging |
Het |
| Trpc3 |
T |
C |
3: 36,694,804 (GRCm39) |
N717D |
probably damaging |
Het |
| Vwa5b1 |
T |
C |
4: 138,327,499 (GRCm39) |
D359G |
probably damaging |
Het |
| Wapl |
A |
G |
14: 34,414,046 (GRCm39) |
T303A |
probably benign |
Het |
| Zfp280d |
T |
C |
9: 72,219,944 (GRCm39) |
S240P |
probably damaging |
Het |
|
| Other mutations in Zfp128 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01140:Zfp128
|
APN |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01293:Zfp128
|
APN |
7 |
12,625,351 (GRCm39) |
makesense |
probably null |
|
|
IGL02067:Zfp128
|
APN |
7 |
12,618,977 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02146:Zfp128
|
APN |
7 |
12,623,959 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02654:Zfp128
|
APN |
7 |
12,618,606 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03066:Zfp128
|
APN |
7 |
12,624,044 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03113:Zfp128
|
APN |
7 |
12,624,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03237:Zfp128
|
APN |
7 |
12,624,953 (GRCm39) |
missense |
probably benign |
0.28 |
|
prayer
|
UTSW |
7 |
12,624,563 (GRCm39) |
nonsense |
probably null |
|
|
R0783:Zfp128
|
UTSW |
7 |
12,624,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Zfp128
|
UTSW |
7 |
12,624,563 (GRCm39) |
nonsense |
probably null |
|
|
R1806:Zfp128
|
UTSW |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2021:Zfp128
|
UTSW |
7 |
12,623,956 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3792:Zfp128
|
UTSW |
7 |
12,618,659 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4105:Zfp128
|
UTSW |
7 |
12,618,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4167:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4168:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5743:Zfp128
|
UTSW |
7 |
12,618,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Zfp128
|
UTSW |
7 |
12,624,897 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6799:Zfp128
|
UTSW |
7 |
12,624,826 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7102:Zfp128
|
UTSW |
7 |
12,624,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Zfp128
|
UTSW |
7 |
12,624,461 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7428:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7504:Zfp128
|
UTSW |
7 |
12,624,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7539:Zfp128
|
UTSW |
7 |
12,624,479 (GRCm39) |
nonsense |
probably null |
|
|
R7636:Zfp128
|
UTSW |
7 |
12,624,039 (GRCm39) |
missense |
probably benign |
|
|
R7755:Zfp128
|
UTSW |
7 |
12,624,240 (GRCm39) |
nonsense |
probably null |
|
|
R7820:Zfp128
|
UTSW |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8269:Zfp128
|
UTSW |
7 |
12,624,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Zfp128
|
UTSW |
7 |
12,625,113 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9361:Zfp128
|
UTSW |
7 |
12,624,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9381:Zfp128
|
UTSW |
7 |
12,624,897 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2016-08-02 |
Incidental Mutation