Incidental Mutation 'IGL03077:Olfr1255'
ID417724
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1255
Ensembl Gene ENSMUSG00000045148
Gene Nameolfactory receptor 1255
SynonymsGA_x6K02T2Q125-51257221-51258135, MOR232-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL03077
Quality Score
Status
Chromosome2
Chromosomal Location89812051-89817860 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 89817142 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Alanine at position 266 (D266A)
Ref Sequence ENSEMBL: ENSMUSP00000150299 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057369] [ENSMUST00000214508]
Predicted Effect probably damaging
Transcript: ENSMUST00000057369
AA Change: D272A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000060602
Gene: ENSMUSG00000045148
AA Change: D272A

DomainStartEndE-ValueType
Pfam:7tm_4 35 309 5.2e-44 PFAM
Pfam:7tm_1 45 291 4.9e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214508
AA Change: D266A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik G A 15: 8,212,795 probably benign Het
Abcg8 A G 17: 84,691,880 N135D probably damaging Het
Ak4 T C 4: 101,419,951 L44P probably damaging Het
Angpt1 C A 15: 42,476,422 G298* probably null Het
Appl2 C T 10: 83,621,759 probably benign Het
Arhgap19 T A 19: 41,781,321 H341L probably benign Het
Chmp5 T C 4: 40,952,438 S98P probably benign Het
Chp1 A T 2: 119,584,600 Q161L probably benign Het
Clgn T C 8: 83,424,140 V478A probably benign Het
Cyp2b19 A T 7: 26,762,384 M210L probably benign Het
Eif4g3 T A 4: 138,125,855 V244D probably damaging Het
Ftcd T C 10: 76,581,627 I300T probably damaging Het
Gm12886 C T 4: 121,415,500 probably benign Het
Klrb1f A T 6: 129,053,802 E92V probably null Het
Krt23 A G 11: 99,483,874 probably benign Het
Mib2 T G 4: 155,659,443 R47S probably benign Het
Mindy4 A G 6: 55,309,330 T728A probably damaging Het
Myh15 A G 16: 49,096,538 N407S probably benign Het
Nlrp4f A G 13: 65,194,598 V411A probably benign Het
Olfr1118 T C 2: 87,309,712 *328Q probably null Het
Otud4 T G 8: 79,673,458 S934A probably damaging Het
P3h1 C T 4: 119,236,786 R213W probably damaging Het
Phrf1 A T 7: 141,254,968 K19* probably null Het
Prl3b1 A T 13: 27,245,776 M66L probably benign Het
Psmd7 T C 8: 107,582,467 T149A probably benign Het
Samd4b T C 7: 28,406,443 D450G probably damaging Het
Scn3a G A 2: 65,536,672 A2V probably damaging Het
Snrpa G A 7: 27,191,761 T95I probably benign Het
Traip A G 9: 107,962,926 probably benign Het
Trbc1 T A 6: 41,538,449 probably benign Het
Trim72 A T 7: 128,007,841 M181L probably benign Het
Ttc41 T C 10: 86,758,348 Y882H probably damaging Het
Vmn1r191 A C 13: 22,179,146 I146S probably benign Het
Vmn2r9 G T 5: 108,848,307 probably benign Het
Vps13a A G 19: 16,710,882 S854P probably benign Het
Wdfy1 T C 1: 79,714,905 K232E possibly damaging Het
Xpr1 A T 1: 155,281,028 D625E possibly damaging Het
Zbbx T A 3: 75,081,846 T317S possibly damaging Het
Other mutations in Olfr1255
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01643:Olfr1255 APN 2 89816673 missense probably damaging 1.00
IGL02902:Olfr1255 APN 2 89817164 nonsense probably null
IGL03087:Olfr1255 APN 2 89816671 missense probably damaging 1.00
IGL03371:Olfr1255 APN 2 89817165 missense possibly damaging 0.64
R0683:Olfr1255 UTSW 2 89817178 missense probably damaging 1.00
R1428:Olfr1255 UTSW 2 89816381 missense probably damaging 1.00
R1567:Olfr1255 UTSW 2 89817184 missense probably damaging 1.00
R3810:Olfr1255 UTSW 2 89817051 missense probably damaging 1.00
R3812:Olfr1255 UTSW 2 89817051 missense probably damaging 1.00
R4900:Olfr1255 UTSW 2 89816968 missense possibly damaging 0.58
R5538:Olfr1255 UTSW 2 89816620 missense probably damaging 1.00
R5770:Olfr1255 UTSW 2 89816549 missense probably damaging 1.00
R5894:Olfr1255 UTSW 2 89817213 missense possibly damaging 0.59
R5942:Olfr1255 UTSW 2 89816340 nonsense probably null
R6263:Olfr1255 UTSW 2 89816760 missense probably damaging 1.00
R6271:Olfr1255 UTSW 2 89816562 missense probably damaging 0.99
R6651:Olfr1255 UTSW 2 89816896 missense probably benign 0.13
R7298:Olfr1255 UTSW 2 89816521 missense probably damaging 0.98
R7379:Olfr1255 UTSW 2 89816689 missense probably benign 0.00
R7465:Olfr1255 UTSW 2 89816536 missense probably damaging 1.00
R7546:Olfr1255 UTSW 2 89817019 missense probably benign 0.00
R7546:Olfr1255 UTSW 2 89817194 missense probably damaging 0.99
Posted On2016-08-02