Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03078:Wdr95'

417766

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr95

Ensembl Gene

ENSMUSG00000029658

Gene Name

WD40 repeat domain 95

Synonyms

4930434E21Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.074) question?

Stock #

IGL03078

Quality Score

Status

Chromosome

Chromosomal Location

149452144-149535359 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 149535062 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 598 (A598V)

Ref Sequence

ENSEMBL: ENSMUSP00000106128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110502] [ENSMUST00000201452] [ENSMUST00000202361] [ENSMUST00000202902]

AlphaFold

D3Z7A8

Predicted Effect

possibly damaging
Transcript: ENSMUST00000110502
AA Change: A598V

PolyPhen 2 Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000106128
Gene: ENSMUSG00000029658
AA Change: A598V

Domain	Start	End	E-Value	Type
Pfam:WD40	4	28	3.3e-3	PFAM
WD40	32	71	4.38e-5	SMART
WD40	120	159	3.27e-4	SMART
WD40	162	203	1.71e-7	SMART
WD40	206	249	3.57e0	SMART
WD40	263	301	1.7e-2	SMART
Blast:WD40	315	363	3e-14	BLAST
Blast:WD40	367	408	4e-13	BLAST
WD40	421	460	2.01e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000201452

SMART Domains

Protein: ENSMUSP00000144654
Gene: ENSMUSG00000029657

Domain	Start	End	E-Value	Type
Pfam:HSP70	3	709	7.3e-190	PFAM
low complexity region	756	768	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000202361

SMART Domains

Protein: ENSMUSP00000144413
Gene: ENSMUSG00000029657

Domain	Start	End	E-Value	Type
Pfam:HSP70	3	709	7.3e-190	PFAM
low complexity region	756	768	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000202902
AA Change: A740V

PolyPhen 2 Score 0.413 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000144385
Gene: ENSMUSG00000029658
AA Change: A740V

Domain	Start	End	E-Value	Type
Blast:WD40	44	83	9e-11	BLAST
WD40	132	170	1.61e-3	SMART
WD40	174	213	4.38e-5	SMART
WD40	262	301	3.27e-4	SMART
WD40	304	345	1.71e-7	SMART
WD40	348	391	3.57e0	SMART
WD40	405	443	1.7e-2	SMART
Blast:WD40	457	505	3e-14	BLAST
Blast:WD40	509	550	4e-13	BLAST
WD40	563	602	2.01e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	T	A	11: 110,167,371 (GRCm39)	K1482*	probably null	Het
Abtb3	C	T	10: 85,468,027 (GRCm39)	A774V	probably damaging	Het
Adam15	A	G	3: 89,253,244 (GRCm39)		probably benign	Het
Adamdec1	C	T	14: 68,806,299 (GRCm39)	R392H	possibly damaging	Het
Anxa7	T	C	14: 20,506,624 (GRCm39)	K439E	probably damaging	Het
Arap2	T	A	5: 62,890,408 (GRCm39)		probably benign	Het
Asic5	A	G	3: 81,921,735 (GRCm39)	E367G	possibly damaging	Het
Cubn	T	C	2: 13,291,905 (GRCm39)	T3307A	possibly damaging	Het
Dnd1	T	C	18: 36,899,197 (GRCm39)	E8G	probably damaging	Het
Eif2ak1	T	C	5: 143,810,587 (GRCm39)	I99T	probably benign	Het
Fras1	C	T	5: 96,783,994 (GRCm39)	R833C	probably damaging	Het
Hectd1	A	G	12: 51,849,019 (GRCm39)	S362P	probably damaging	Het
Hs3st4	A	G	7: 123,996,669 (GRCm39)	E445G	probably damaging	Het
Kcnh1	A	G	1: 192,117,108 (GRCm39)	T21A	probably damaging	Het
Kif26b	G	A	1: 178,698,291 (GRCm39)	R594H	probably damaging	Het
Lsm14b	T	C	2: 179,668,521 (GRCm39)	I74T	probably damaging	Het
Myh2	T	A	11: 67,081,256 (GRCm39)	S1291T	probably benign	Het
Myo3b	T	A	2: 70,117,335 (GRCm39)	F923I	probably damaging	Het
Obscn	T	C	11: 58,969,624 (GRCm39)		probably null	Het
Or51f1d	T	C	7: 102,701,036 (GRCm39)	F177S	probably damaging	Het
Or8b53	C	T	9: 38,667,541 (GRCm39)	Q186*	probably null	Het
Piezo2	A	C	18: 63,203,146 (GRCm39)	M1484R	probably damaging	Het
Rhoh	T	A	5: 66,050,231 (GRCm39)	V167D	probably damaging	Het
Rspo3	T	C	10: 29,380,657 (GRCm39)	Y119C	probably damaging	Het
Scpep1	T	A	11: 88,826,657 (GRCm39)	I260F	possibly damaging	Het
Slc15a3	T	A	19: 10,834,609 (GRCm39)	F497I	probably damaging	Het
Stom	T	C	2: 35,205,941 (GRCm39)	K263E	probably damaging	Het
Taf4b	C	A	18: 14,946,611 (GRCm39)	A478E	possibly damaging	Het
Ttn	C	T	2: 76,600,594 (GRCm39)		probably benign	Het

Other mutations in Wdr95

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00429:Wdr95	APN	5	149,518,709 (GRCm39)	critical splice acceptor site	probably benign	0.00
IGL02352:Wdr95	APN	5	149,504,084 (GRCm39)	missense	probably damaging	0.99
IGL02359:Wdr95	APN	5	149,504,084 (GRCm39)	missense	probably damaging	0.99
IGL02478:Wdr95	APN	5	149,519,786 (GRCm39)	missense	probably benign	0.02
IGL03201:Wdr95	APN	5	149,505,352 (GRCm39)	splice site	probably null
P0037:Wdr95	UTSW	5	149,511,536 (GRCm39)	missense	probably benign	0.27
R0115:Wdr95	UTSW	5	149,487,855 (GRCm39)	missense	probably damaging	1.00
R0538:Wdr95	UTSW	5	149,504,271 (GRCm39)	missense	probably damaging	1.00
R0606:Wdr95	UTSW	5	149,511,595 (GRCm39)	missense	probably damaging	1.00
R0723:Wdr95	UTSW	5	149,497,513 (GRCm39)	missense	probably damaging	1.00
R1104:Wdr95	UTSW	5	149,529,802 (GRCm39)	missense	probably benign	0.00
R1233:Wdr95	UTSW	5	149,518,829 (GRCm39)	missense	probably benign	0.00
R1233:Wdr95	UTSW	5	149,505,323 (GRCm39)	missense	possibly damaging	0.61
R1344:Wdr95	UTSW	5	149,511,563 (GRCm39)	missense	probably damaging	1.00
R1513:Wdr95	UTSW	5	149,522,759 (GRCm39)	missense	probably benign	0.00
R1623:Wdr95	UTSW	5	149,497,581 (GRCm39)	missense	probably damaging	1.00
R1633:Wdr95	UTSW	5	149,516,637 (GRCm39)	missense	probably damaging	0.98
R1664:Wdr95	UTSW	5	149,518,752 (GRCm39)	missense	probably damaging	0.98
R1686:Wdr95	UTSW	5	149,516,566 (GRCm39)	missense	probably damaging	1.00
R1741:Wdr95	UTSW	5	149,518,861 (GRCm39)	splice site	probably null
R1750:Wdr95	UTSW	5	149,505,351 (GRCm39)	splice site	probably null
R1774:Wdr95	UTSW	5	149,487,857 (GRCm39)	nonsense	probably null
R1831:Wdr95	UTSW	5	149,475,891 (GRCm39)	missense	probably damaging	1.00
R1838:Wdr95	UTSW	5	149,522,831 (GRCm39)	missense	probably benign	0.00
R1907:Wdr95	UTSW	5	149,475,891 (GRCm39)	missense	probably damaging	1.00
R2019:Wdr95	UTSW	5	149,497,613 (GRCm39)	splice site	probably benign
R2063:Wdr95	UTSW	5	149,502,627 (GRCm39)	splice site	probably null
R2392:Wdr95	UTSW	5	149,504,135 (GRCm39)	missense	probably benign	0.03
R2863:Wdr95	UTSW	5	149,505,321 (GRCm39)	nonsense	probably null
R4116:Wdr95	UTSW	5	149,521,040 (GRCm39)	missense	probably benign	0.02
R4237:Wdr95	UTSW	5	149,486,802 (GRCm39)	nonsense	probably null
R4420:Wdr95	UTSW	5	149,456,131 (GRCm39)	missense	probably damaging	0.99
R4639:Wdr95	UTSW	5	149,505,279 (GRCm39)	splice site	probably benign
R4824:Wdr95	UTSW	5	149,518,797 (GRCm39)	missense	probably damaging	1.00
R4911:Wdr95	UTSW	5	149,535,157 (GRCm39)	nonsense	probably null
R5016:Wdr95	UTSW	5	149,468,266 (GRCm39)	missense	probably benign	0.00
R5458:Wdr95	UTSW	5	149,487,879 (GRCm39)	missense	probably damaging	1.00
R5486:Wdr95	UTSW	5	149,519,795 (GRCm39)	nonsense	probably null
R5613:Wdr95	UTSW	5	149,507,935 (GRCm39)	missense	probably damaging	1.00
R5906:Wdr95	UTSW	5	149,487,692 (GRCm39)	missense	possibly damaging	0.50
R5956:Wdr95	UTSW	5	149,517,947 (GRCm39)	missense	probably benign	0.00
R6309:Wdr95	UTSW	5	149,504,268 (GRCm39)	critical splice acceptor site	probably null
R6867:Wdr95	UTSW	5	149,504,388 (GRCm39)	splice site	probably null
R6964:Wdr95	UTSW	5	149,505,315 (GRCm39)	missense	probably damaging	1.00
R7008:Wdr95	UTSW	5	149,535,005 (GRCm39)	missense	probably benign	0.00
R7208:Wdr95	UTSW	5	149,518,836 (GRCm39)	missense	probably benign	0.02
R7309:Wdr95	UTSW	5	149,529,758 (GRCm39)	missense	probably benign	0.01
R7504:Wdr95	UTSW	5	149,505,311 (GRCm39)	missense	probably damaging	0.99
R7660:Wdr95	UTSW	5	149,517,945 (GRCm39)	missense	possibly damaging	0.86
R7997:Wdr95	UTSW	5	149,502,622 (GRCm39)	critical splice donor site	probably null
R8084:Wdr95	UTSW	5	149,511,598 (GRCm39)	missense	probably damaging	1.00
R8356:Wdr95	UTSW	5	149,502,572 (GRCm39)	missense	probably damaging	1.00
R8456:Wdr95	UTSW	5	149,502,572 (GRCm39)	missense	probably damaging	1.00
R8523:Wdr95	UTSW	5	149,497,461 (GRCm39)	missense	probably damaging	1.00
R8682:Wdr95	UTSW	5	149,518,752 (GRCm39)	missense	possibly damaging	0.94
R9451:Wdr95	UTSW	5	149,504,165 (GRCm39)	missense	probably benign	0.01
R9453:Wdr95	UTSW	5	149,475,917 (GRCm39)	missense	probably damaging	0.99
R9779:Wdr95	UTSW	5	149,505,293 (GRCm39)	missense	probably benign	0.01
X0024:Wdr95	UTSW	5	149,511,632 (GRCm39)	missense	possibly damaging	0.81
Z1176:Wdr95	UTSW	5	149,489,901 (GRCm39)	missense	probably benign	0.34
Z1177:Wdr95	UTSW	5	149,468,241 (GRCm39)	missense	probably damaging	0.98

Posted On

2016-08-02