Incidental Mutation 'IGL03079:Tecrl'
ID417780
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tecrl
Ensembl Gene ENSMUSG00000049537
Gene Nametrans-2,3-enoyl-CoA reductase-like
SynonymsSrd5a2l2, D330017N19Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.226) question?
Stock #IGL03079
Quality Score
Status
Chromosome5
Chromosomal Location83278145-83355195 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 83294600 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Tyrosine at position 209 (H209Y)
Ref Sequence ENSEMBL: ENSMUSP00000062122 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053543]
Predicted Effect probably damaging
Transcript: ENSMUST00000053543
AA Change: H209Y

PolyPhen 2 Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000062122
Gene: ENSMUSG00000049537
AA Change: H209Y

DomainStartEndE-ValueType
PDB:2DZJ|A 53 135 1e-17 PDB
Blast:UBQ 59 135 2e-7 BLAST
transmembrane domain 139 161 N/A INTRINSIC
Pfam:Steroid_dh 208 361 3.8e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117478
Predicted Effect unknown
Transcript: ENSMUST00000146669
AA Change: H169Y
SMART Domains Protein: ENSMUSP00000115144
Gene: ENSMUSG00000049537
AA Change: H169Y

DomainStartEndE-ValueType
PDB:2DZJ|A 39 93 1e-11 PDB
transmembrane domain 100 122 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alx1 T A 10: 103,009,348 H274L probably damaging Het
Arl6ip4 A T 5: 124,116,927 H59L possibly damaging Het
C1ra A G 6: 124,519,835 Y410C probably damaging Het
Ceacam11 A G 7: 17,978,436 N270S probably benign Het
Cmtr1 T A 17: 29,663,293 N39K possibly damaging Het
Cmya5 T C 13: 93,097,701 D293G possibly damaging Het
Cyp2d11 T C 15: 82,390,966 E260G probably damaging Het
Dnajc13 C T 9: 104,212,869 W700* probably null Het
Efemp2 G T 19: 5,475,127 L20F probably damaging Het
Grasp T C 15: 101,230,567 V162A probably damaging Het
Hars G A 18: 36,770,503 L289F probably damaging Het
Hdlbp A G 1: 93,413,940 probably benign Het
Iqgap3 A T 3: 88,113,170 M374L probably benign Het
Lrig2 A T 3: 104,490,971 W281R probably damaging Het
Lyg2 C T 1: 37,907,646 E185K possibly damaging Het
Maml2 A G 9: 13,621,616 probably benign Het
March11 T C 15: 26,311,058 S207P probably damaging Het
Nipa2 A T 7: 55,933,457 V180E probably damaging Het
Olfr731 A T 14: 50,238,124 C254S possibly damaging Het
P2rx5 A G 11: 73,164,888 D57G possibly damaging Het
Pxdn T C 12: 30,002,998 I1058T probably damaging Het
Rxfp3 C A 15: 11,036,823 M154I possibly damaging Het
Slc3a1 T A 17: 85,059,823 Y479* probably null Het
Ttll5 T C 12: 85,876,558 Y270H probably damaging Het
Usp34 A G 11: 23,432,247 E1986G possibly damaging Het
Zfp719 A G 7: 43,591,166 Y726C probably damaging Het
Zfp810 T C 9: 22,284,127 E7G probably damaging Het
Other mutations in Tecrl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01981:Tecrl APN 5 83294606 missense probably benign
IGL02067:Tecrl APN 5 83284275 missense probably benign 0.05
IGL02111:Tecrl APN 5 83354792 missense probably damaging 1.00
IGL02391:Tecrl APN 5 83354827 missense probably benign 0.00
IGL02860:Tecrl APN 5 83354997 missense probably benign 0.01
IGL03109:Tecrl APN 5 83309309 intron probably benign
BB004:Tecrl UTSW 5 83354819 missense probably damaging 1.00
BB014:Tecrl UTSW 5 83354819 missense probably damaging 1.00
R0095:Tecrl UTSW 5 83294570 splice site probably benign
R0347:Tecrl UTSW 5 83294632 missense probably damaging 1.00
R0372:Tecrl UTSW 5 83294659 missense probably damaging 1.00
R0403:Tecrl UTSW 5 83354758 splice site probably benign
R0426:Tecrl UTSW 5 83354763 splice site probably benign
R0597:Tecrl UTSW 5 83354928 nonsense probably null
R1607:Tecrl UTSW 5 83280508 splice site probably null
R1771:Tecrl UTSW 5 83291287 missense probably damaging 1.00
R1800:Tecrl UTSW 5 83279230 missense probably damaging 1.00
R1815:Tecrl UTSW 5 83279234 missense probably benign 0.01
R1869:Tecrl UTSW 5 83354859 missense probably benign 0.00
R1870:Tecrl UTSW 5 83354859 missense probably benign 0.00
R4296:Tecrl UTSW 5 83313327 nonsense probably null
R4471:Tecrl UTSW 5 83313287 missense probably benign
R6281:Tecrl UTSW 5 83294606 missense probably damaging 1.00
R6343:Tecrl UTSW 5 83294600 missense probably damaging 0.96
R6866:Tecrl UTSW 5 83313314 missense probably damaging 1.00
R6948:Tecrl UTSW 5 83309250 missense probably benign
R6971:Tecrl UTSW 5 83354802 missense possibly damaging 0.58
R6981:Tecrl UTSW 5 83354921 missense possibly damaging 0.83
R7246:Tecrl UTSW 5 83279335 missense probably damaging 0.99
R7282:Tecrl UTSW 5 83354907 missense probably benign 0.26
R7444:Tecrl UTSW 5 83355068 unclassified probably benign
R7900:Tecrl UTSW 5 83279341 missense probably benign 0.04
R7927:Tecrl UTSW 5 83354819 missense probably damaging 1.00
R8246:Tecrl UTSW 5 83279309 missense probably damaging 0.99
R8360:Tecrl UTSW 5 83300917 missense probably damaging 1.00
X0019:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0024:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0034:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0035:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0036:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0037:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0038:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0039:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0040:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0052:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0053:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0054:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0058:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0060:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0061:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0062:Tecrl UTSW 5 83338252 missense probably benign 0.32
X0063:Tecrl UTSW 5 83338252 missense probably benign 0.32
Posted On2016-08-02