Incidental Mutation 'IGL03079:Lyg2'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lyg2
Ensembl Gene ENSMUSG00000061584
Gene Namelysozyme G-like 2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL03079
Quality Score
Chromosomal Location37905923-37916493 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 37907646 bp
Amino Acid Change Glutamic Acid to Lysine at position 185 (E185K)
Ref Sequence ENSEMBL: ENSMUSP00000077422 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078307]
Predicted Effect possibly damaging
Transcript: ENSMUST00000078307
AA Change: E185K

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000077422
Gene: ENSMUSG00000061584
AA Change: E185K

signal peptide 1 19 N/A INTRINSIC
SCOP:d153l__ 39 213 5e-45 SMART
PDB:1LSP|A 40 213 2e-56 PDB
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alx1 T A 10: 103,009,348 H274L probably damaging Het
Arl6ip4 A T 5: 124,116,927 H59L possibly damaging Het
C1ra A G 6: 124,519,835 Y410C probably damaging Het
Ceacam11 A G 7: 17,978,436 N270S probably benign Het
Cmtr1 T A 17: 29,663,293 N39K possibly damaging Het
Cmya5 T C 13: 93,097,701 D293G possibly damaging Het
Cyp2d11 T C 15: 82,390,966 E260G probably damaging Het
Dnajc13 C T 9: 104,212,869 W700* probably null Het
Efemp2 G T 19: 5,475,127 L20F probably damaging Het
Grasp T C 15: 101,230,567 V162A probably damaging Het
Hars G A 18: 36,770,503 L289F probably damaging Het
Hdlbp A G 1: 93,413,940 probably benign Het
Iqgap3 A T 3: 88,113,170 M374L probably benign Het
Lrig2 A T 3: 104,490,971 W281R probably damaging Het
Maml2 A G 9: 13,621,616 probably benign Het
March11 T C 15: 26,311,058 S207P probably damaging Het
Nipa2 A T 7: 55,933,457 V180E probably damaging Het
Olfr731 A T 14: 50,238,124 C254S possibly damaging Het
P2rx5 A G 11: 73,164,888 D57G possibly damaging Het
Pxdn T C 12: 30,002,998 I1058T probably damaging Het
Rxfp3 C A 15: 11,036,823 M154I possibly damaging Het
Slc3a1 T A 17: 85,059,823 Y479* probably null Het
Tecrl G A 5: 83,294,600 H209Y probably damaging Het
Ttll5 T C 12: 85,876,558 Y270H probably damaging Het
Usp34 A G 11: 23,432,247 E1986G possibly damaging Het
Zfp719 A G 7: 43,591,166 Y726C probably damaging Het
Zfp810 T C 9: 22,284,127 E7G probably damaging Het
Other mutations in Lyg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Lyg2 APN 1 37909967 missense probably damaging 1.00
IGL03123:Lyg2 APN 1 37915764 utr 5 prime probably benign
R0543:Lyg2 UTSW 1 37911107 missense possibly damaging 0.94
R2250:Lyg2 UTSW 1 37915735 missense probably benign 0.25
R2258:Lyg2 UTSW 1 37908996 missense probably benign 0.00
R3884:Lyg2 UTSW 1 37910069 missense probably damaging 1.00
R4807:Lyg2 UTSW 1 37911067 missense possibly damaging 0.54
R5991:Lyg2 UTSW 1 37915719 critical splice donor site probably null
R6328:Lyg2 UTSW 1 37911113 missense probably benign 0.33
R7439:Lyg2 UTSW 1 37911137 missense possibly damaging 0.46
Posted On2016-08-02