Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03080:Psg23'

417806

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg23

Ensembl Gene

ENSMUSG00000074359

Gene Name

pregnancy-specific glycoprotein 23

Synonyms

1620401C02Rik

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03080

Quality Score

Status

Chromosome

Chromosomal Location

18606343-18616501 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18606985 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 448 (Y448F)

Ref Sequence

ENSEMBL: ENSMUSP00000056586 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057810]

Predicted Effect

probably damaging
Transcript: ENSMUST00000057810
AA Change: Y448F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: Y448F

Domain	Start	End	E-Value	Type
IG	39	138	2.03e-4	SMART
IG	159	260	4.16e-1	SMART
IG	276	375	1.25e-4	SMART
IGc2	393	457	4.7e-9	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932415D10Rik	T	C	10: 82,283,982	D428G	probably damaging	Het
Abce1	T	C	8: 79,703,001		probably null	Het
Adgrf3	T	C	5: 30,196,829	M734V	probably benign	Het
Aqp8	T	G	7: 123,466,579		probably benign	Het
Ces1d	C	A	8: 93,169,718		probably null	Het
Cntn4	A	G	6: 106,655,539	D508G	probably damaging	Het
Cyp11b1	A	T	15: 74,839,436		probably null	Het
Dnah8	A	G	17: 30,719,006	D1619G	probably benign	Het
Ephb4	T	A	5: 137,354,083		probably benign	Het
Ffar3	A	T	7: 30,855,322	V191E	probably damaging	Het
Galnt1	T	A	18: 24,269,517	D310E	probably damaging	Het
Gm2075	A	T	12: 88,011,845		probably benign	Het
Igf2r	T	C	17: 12,726,676	Y342C	probably benign	Het
Jade1	T	A	3: 41,600,075	C251*	probably null	Het
Jhy	T	C	9: 40,944,357	E278G	probably damaging	Het
Kif24	A	C	4: 41,394,417	S819A	probably benign	Het
Lrp8	T	C	4: 107,855,799	L344P	probably damaging	Het
Lrrc27	A	G	7: 139,230,237	T375A	probably benign	Het
Mbd3	C	T	10: 80,393,251	R204Q	probably damaging	Het
Nab2	T	C	10: 127,664,794	N143S	possibly damaging	Het
Nkiras2	T	C	11: 100,624,279		probably null	Het
Olfr868	A	T	9: 20,101,409	I217F	probably damaging	Het
Palm	C	A	10: 79,819,117	H74Q	probably damaging	Het
Pros1	T	A	16: 62,918,143	N408K	probably damaging	Het
Ranbp2	C	A	10: 58,476,791	P1111Q	probably benign	Het
Rims2	A	G	15: 39,535,903	S1115G	probably damaging	Het
Scn7a	T	C	2: 66,697,816	T777A	probably benign	Het
Stard3nl	A	T	13: 19,370,478		probably null	Het
Sult1d1	T	C	5: 87,556,988	D214G	probably benign	Het
Tmprss12	T	C	15: 100,292,648	W300R	probably damaging	Het
Tmprss2	T	C	16: 97,596,844	Y44C	probably damaging	Het
Ttk	A	G	9: 83,843,083	N154D	probably damaging	Het
Tyw1	T	C	5: 130,267,055	Y108H	probably damaging	Het
Vmn2r44	C	A	7: 8,383,245		probably benign	Het
Zcchc11	T	A	4: 108,505,824	S444R	probably damaging	Het
Zfand1	A	G	3: 10,340,737	*269Q	probably null	Het
Zfp142	A	T	1: 74,571,209	D1039E	probably benign	Het
Zkscan5	G	T	5: 145,218,650	S377I	probably damaging	Het

Other mutations in Psg23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00814:Psg23	APN	7	18614683	nonsense	probably null
IGL01309:Psg23	APN	7	18614540	missense	probably damaging	1.00
IGL01736:Psg23	APN	7	18612197	missense	possibly damaging	0.76
IGL02142:Psg23	APN	7	18610420	missense	probably benign	0.01
IGL02728:Psg23	APN	7	18606928	missense	probably benign	0.02
IGL03130:Psg23	APN	7	18610416	missense	probably benign	0.25
R0113:Psg23	UTSW	7	18612002	missense	probably benign	0.31
R0137:Psg23	UTSW	7	18614633	missense	probably benign	0.00
R0544:Psg23	UTSW	7	18614682	missense	probably damaging	1.00
R1368:Psg23	UTSW	7	18614720	missense	probably benign	0.13
R1840:Psg23	UTSW	7	18610438	missense	possibly damaging	0.67
R1869:Psg23	UTSW	7	18614618	missense	probably benign	0.09
R1875:Psg23	UTSW	7	18610450	missense	probably benign	0.10
R2041:Psg23	UTSW	7	18614778	missense	possibly damaging	0.78
R2096:Psg23	UTSW	7	18614743	missense	probably damaging	1.00
R3110:Psg23	UTSW	7	18610444	missense	possibly damaging	0.72
R3112:Psg23	UTSW	7	18610444	missense	possibly damaging	0.72
R3790:Psg23	UTSW	7	18612201	missense	probably benign	0.00
R3892:Psg23	UTSW	7	18612041	missense	probably damaging	1.00
R4074:Psg23	UTSW	7	18607118	missense	possibly damaging	0.66
R4200:Psg23	UTSW	7	18612065	missense	probably damaging	1.00
R4865:Psg23	UTSW	7	18612114	missense	probably benign	0.14
R5337:Psg23	UTSW	7	18612072	missense	probably benign	0.00
R6016:Psg23	UTSW	7	18612187	missense	probably benign	0.00
R6951:Psg23	UTSW	7	18614711	missense	probably damaging	1.00
R7033:Psg23	UTSW	7	18614744	missense	possibly damaging	0.82
R7212:Psg23	UTSW	7	18607139	missense	probably benign	0.00
R7427:Psg23	UTSW	7	18611983	splice site	probably null
R7527:Psg23	UTSW	7	18614774	missense	probably damaging	1.00
R7814:Psg23	UTSW	7	18606914	makesense	probably null

Posted On

2016-08-02