Incidental Mutation 'IGL03080:Psg23'
ID417806
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Psg23
Ensembl Gene ENSMUSG00000074359
Gene Namepregnancy-specific glycoprotein 23
Synonyms1620401C02Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03080
Quality Score
Status
Chromosome7
Chromosomal Location18606343-18616501 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 18606985 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 448 (Y448F)
Ref Sequence ENSEMBL: ENSMUSP00000056586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057810]
Predicted Effect probably damaging
Transcript: ENSMUST00000057810
AA Change: Y448F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: Y448F

DomainStartEndE-ValueType
IG 39 138 2.03e-4 SMART
IG 159 260 4.16e-1 SMART
IG 276 375 1.25e-4 SMART
IGc2 393 457 4.7e-9 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932415D10Rik T C 10: 82,283,982 D428G probably damaging Het
Abce1 T C 8: 79,703,001 probably null Het
Adgrf3 T C 5: 30,196,829 M734V probably benign Het
Aqp8 T G 7: 123,466,579 probably benign Het
Ces1d C A 8: 93,169,718 probably null Het
Cntn4 A G 6: 106,655,539 D508G probably damaging Het
Cyp11b1 A T 15: 74,839,436 probably null Het
Dnah8 A G 17: 30,719,006 D1619G probably benign Het
Ephb4 T A 5: 137,354,083 probably benign Het
Ffar3 A T 7: 30,855,322 V191E probably damaging Het
Galnt1 T A 18: 24,269,517 D310E probably damaging Het
Gm2075 A T 12: 88,011,845 probably benign Het
Igf2r T C 17: 12,726,676 Y342C probably benign Het
Jade1 T A 3: 41,600,075 C251* probably null Het
Jhy T C 9: 40,944,357 E278G probably damaging Het
Kif24 A C 4: 41,394,417 S819A probably benign Het
Lrp8 T C 4: 107,855,799 L344P probably damaging Het
Lrrc27 A G 7: 139,230,237 T375A probably benign Het
Mbd3 C T 10: 80,393,251 R204Q probably damaging Het
Nab2 T C 10: 127,664,794 N143S possibly damaging Het
Nkiras2 T C 11: 100,624,279 probably null Het
Olfr868 A T 9: 20,101,409 I217F probably damaging Het
Palm C A 10: 79,819,117 H74Q probably damaging Het
Pros1 T A 16: 62,918,143 N408K probably damaging Het
Ranbp2 C A 10: 58,476,791 P1111Q probably benign Het
Rims2 A G 15: 39,535,903 S1115G probably damaging Het
Scn7a T C 2: 66,697,816 T777A probably benign Het
Stard3nl A T 13: 19,370,478 probably null Het
Sult1d1 T C 5: 87,556,988 D214G probably benign Het
Tmprss12 T C 15: 100,292,648 W300R probably damaging Het
Tmprss2 T C 16: 97,596,844 Y44C probably damaging Het
Ttk A G 9: 83,843,083 N154D probably damaging Het
Tyw1 T C 5: 130,267,055 Y108H probably damaging Het
Vmn2r44 C A 7: 8,383,245 probably benign Het
Zcchc11 T A 4: 108,505,824 S444R probably damaging Het
Zfand1 A G 3: 10,340,737 *269Q probably null Het
Zfp142 A T 1: 74,571,209 D1039E probably benign Het
Zkscan5 G T 5: 145,218,650 S377I probably damaging Het
Other mutations in Psg23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00814:Psg23 APN 7 18614683 nonsense probably null
IGL01309:Psg23 APN 7 18614540 missense probably damaging 1.00
IGL01736:Psg23 APN 7 18612197 missense possibly damaging 0.76
IGL02142:Psg23 APN 7 18610420 missense probably benign 0.01
IGL02728:Psg23 APN 7 18606928 missense probably benign 0.02
IGL03130:Psg23 APN 7 18610416 missense probably benign 0.25
R0113:Psg23 UTSW 7 18612002 missense probably benign 0.31
R0137:Psg23 UTSW 7 18614633 missense probably benign 0.00
R0544:Psg23 UTSW 7 18614682 missense probably damaging 1.00
R1368:Psg23 UTSW 7 18614720 missense probably benign 0.13
R1840:Psg23 UTSW 7 18610438 missense possibly damaging 0.67
R1869:Psg23 UTSW 7 18614618 missense probably benign 0.09
R1875:Psg23 UTSW 7 18610450 missense probably benign 0.10
R2041:Psg23 UTSW 7 18614778 missense possibly damaging 0.78
R2096:Psg23 UTSW 7 18614743 missense probably damaging 1.00
R3110:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3112:Psg23 UTSW 7 18610444 missense possibly damaging 0.72
R3790:Psg23 UTSW 7 18612201 missense probably benign 0.00
R3892:Psg23 UTSW 7 18612041 missense probably damaging 1.00
R4074:Psg23 UTSW 7 18607118 missense possibly damaging 0.66
R4200:Psg23 UTSW 7 18612065 missense probably damaging 1.00
R4865:Psg23 UTSW 7 18612114 missense probably benign 0.14
R5337:Psg23 UTSW 7 18612072 missense probably benign 0.00
R6016:Psg23 UTSW 7 18612187 missense probably benign 0.00
R6951:Psg23 UTSW 7 18614711 missense probably damaging 1.00
R7033:Psg23 UTSW 7 18614744 missense possibly damaging 0.82
R7212:Psg23 UTSW 7 18607139 missense probably benign 0.00
R7427:Psg23 UTSW 7 18611983 splice site probably null
R7527:Psg23 UTSW 7 18614774 missense probably damaging 1.00
R7814:Psg23 UTSW 7 18606914 makesense probably null
Posted On2016-08-02